Title:
ANTI-INFLAMMATORY COMPOSITION COMPRISING EXTRACELLULAR VESICLES ISOLATED FROM TONSIL-DERIVED MESENCHYMAL STEM CELLS AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2024/053775
Kind Code:
A1
Abstract:
The present invention relates to an anti-inflammatory active composition comprising extracellular vesicles isolated from tonsil-derived mesenchymal stem cells, and specifically, the anti-inflammatory active composition comprising extracellular vesicles isolated from tonsil-derived mesenchymal stem cells of the present invention has excellent inflammatory cytokine TNF-α inhibitory activity and excellent anti-inflammatory cytokine IL-10 increasing activity, and can thus be usefully employed to prevent, inhibit, alleviate, improve, or treat inflammation.
Inventors:
SONG MI HEE (KR)
Application Number:
PCT/KR2022/016439
Publication Date:
March 14, 2024
Filing Date:
October 26, 2022
Export Citation:
Assignee:
HYUNDAEMEDITECH CO LTD (KR)
International Classes:
A61K35/28; A23L33/10; A61K8/98; A61P29/00; A61Q19/00
Foreign References:
| KR20170083786A | 2017-07-19 |
Other References:
KIM JI MIN, KIM JEONG HUN, KIM KEUNYOUNG, SHIN SUNG-CHAN, CHEON YONG-IL, KIM HYUNG SIK, LEE JIN-CHOON, SUNG EUI-SUK, LEE MINHYUNG,: "Tonsil mesenchymal stem cells-derived extracellular vesicles prevent submandibular gland dysfunction in ovariectomized rats", AGING, vol. 14, no. 5, 15 March 2022 (2022-03-15), pages 2194 - 2209, XP093147494, ISSN: 1945-4589, DOI: 10.18632/aging.203947
CHO KYUNG-AH; CHA JE-EUN; KIM JUNGWOO; KIM YU-HEE; RYU KYUNG-HA; WOO SO-YOUN: "Mesenchymal Stem Cell-Derived Exosomes Attenuate TLR7-Mediated Mast Cell Activation", TISSUE ENGINEERING AND REGENERATIVE MEDICINE, SPRINGER SINGAPORE, SINGAPORE, vol. 19, no. 1, 18 November 2021 (2021-11-18), Singapore, pages 117 - 129, XP037671741, ISSN: 1738-2696, DOI: 10.1007/s13770-021-00395-4
CHOI DA-WON, CHO KYUNG-AH, KIM JUNGWOO, LEE HYUN-JI, KIM YU-HEE, PARK JANG-WON, WOO SO-YOUN: "Extracellular vesicles from tonsil‑derived mesenchymal stromal cells show anti‑tumor effect via miR‑199a‑3p", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SPANDIDOS PUBLICATIONS, GR, vol. 48, no. 6, 21 October 2021 (2021-10-21), GR , XP093147497, ISSN: 1107-3756, DOI: 10.3892/ijmm.2021.5054
SHIN SUNG-CHAN, SEO YOOJIN, PARK HEE YOUNG, JUNG DA-WOON, SHIN TAE-HOON, SON HAEJIN, KIM YOUNG KEUM, LEE JIN-CHOON, SUNG EUI-SUK, : "Regenerative potential of tonsil mesenchymal stem cells on surgical cutaneous defect", CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, GB, vol. 9, no. 2, 7 February 2018 (2018-02-07), GB , pages 183, XP093147498, ISSN: 2041-4889, DOI: 10.1038/s41419-017-0248-4
CHO KYUNG-AH; CHA JE-EUN; KIM JUNGWOO; KIM YU-HEE; RYU KYUNG-HA; WOO SO-YOUN: "Mesenchymal Stem Cell-Derived Exosomes Attenuate TLR7-Mediated Mast Cell Activation", TISSUE ENGINEERING AND REGENERATIVE MEDICINE, SPRINGER SINGAPORE, SINGAPORE, vol. 19, no. 1, 18 November 2021 (2021-11-18), Singapore, pages 117 - 129, XP037671741, ISSN: 1738-2696, DOI: 10.1007/s13770-021-00395-4
CHOI DA-WON, CHO KYUNG-AH, KIM JUNGWOO, LEE HYUN-JI, KIM YU-HEE, PARK JANG-WON, WOO SO-YOUN: "Extracellular vesicles from tonsil‑derived mesenchymal stromal cells show anti‑tumor effect via miR‑199a‑3p", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SPANDIDOS PUBLICATIONS, GR, vol. 48, no. 6, 21 October 2021 (2021-10-21), GR , XP093147497, ISSN: 1107-3756, DOI: 10.3892/ijmm.2021.5054
SHIN SUNG-CHAN, SEO YOOJIN, PARK HEE YOUNG, JUNG DA-WOON, SHIN TAE-HOON, SON HAEJIN, KIM YOUNG KEUM, LEE JIN-CHOON, SUNG EUI-SUK, : "Regenerative potential of tonsil mesenchymal stem cells on surgical cutaneous defect", CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, GB, vol. 9, no. 2, 7 February 2018 (2018-02-07), GB , pages 183, XP093147498, ISSN: 2041-4889, DOI: 10.1038/s41419-017-0248-4
Attorney, Agent or Firm:
POLARIS INTERNATIONAL PATENT & LAW FIRM (KR)
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