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Title:
ANTI-INFLAMMATORY COMPOSITION CONTAINING CLAVASPIRIN PEPTIDE ANALOG AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2017/048029
Kind Code:
A1
Abstract:
The present invention relates to an anti-inflammatory composition containing a clavaspirin peptide analog as an active ingredient. CSP-4 peptide, in the present invention, which is a synthetic peptide prepared by substituting the 9 and 12 positions of Styela clava-derived clavaspirin peptide with positively charged lysine (K) amino acid, has an excellent antimicrobial effect on an animal model exhibiting an inflammatory response caused by antibiotic resistant bacteria and shows little cytotoxicity,and thus CSP-4, of the present invention, which is a clavaspirin peptide analog, can be useful as an active ingredient of a pharmaceutical composition for prevention or treatment of inflammatory diseases, a cosmetic composition, a food additive and the like.

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Inventors:
PARK YOONKYUNG (KR)
LEE JONG-KOOK (KR)
Application Number:
PCT/KR2016/010292
Publication Date:
March 23, 2017
Filing Date:
September 12, 2016
Export Citation:
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Assignee:
INDUSTRY-ACADEMIC COOP FOUND CHOSUN UNIV (KR)
International Classes:
A61K38/16; C07K14/435
Foreign References:
US5998374A1999-12-07
KR20150083275A2015-07-17
KR20140055970A2014-05-09
Other References:
LEE, I. -H. ET AL.: "Clavaspirin, an Antibacterial and Haemolytic Peptide from Styela Clava", J. PEPT. RES., vol. 58, no. 6, December 2001 (2001-12-01), pages 445 - 456, XP055374420
LEHRER, ROBERT I. ET AL.: "Natural Peptide Antibiotics from Turucates: Structures, Functions a Pofential Uses", THE SOCIETY FOR INTEGRATIVE AND COMPARATIVE BIOLOGY, vol. 43, no. 2, April 2003 (2003-04-01), pages 313 - 322, XP008024135
Attorney, Agent or Firm:
CHOI, Kyu Whan (KR)
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