Title:
ANTI-INFLAMMATORY, SKIN-REGENERATIVE, WHITENING, ANTIOXIDANT, OR WOUND-HEALING COMPOSITION CONTAINING CULTURE MEDIUM OF ADSC-T CELLS IN WHICH T-ANTIGEN IS INTRODUCED INTO ADIPOSE-DERIVED STEM CELL AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2014/171593
Kind Code:
A1
Abstract:
The present invention relates to an anti-inflammatory, skin-regenerative, whitening, antioxidant, or wound-healing composition containing a culture medium of adipose-derived stem cell-T (ADSC-T) cells as an active ingredient, in which T-antigen is introduced into an adipose-derived stem cell. The culture medium of ADSC-T cells, according to the present invention, has remarkable effects for treating or inhibiting inflammation by alleviating atopic dermatitis, which is an autoimmune disease, and inhibiting NF-κB activities through an increase of an Iκbα expression. Additionally, the culture medium, according to the present invention, exhibits: excellent skin regenerative effects by having effects of enhancing skin collagen elasticity and reducing wounds, in a collagen culture; excellent skin whitening effects by inhibiting tyrosinase activities and melanin production; and excellent anti-oxidation effects by inhibiting DPPH radical activities. Furthermore, the present invention has remarkable wound-healing effects by enhancing cell mobility of fibroblast, and is thus useful for anti-inflammation, skin-regeneration, whitening, anti-oxidation, or healing wounds.
Inventors:
KIM DONGWAN (KR)
PARK HAN NA (KR)
KIM GYU BIN (KR)
PARK HAN NA (KR)
KIM GYU BIN (KR)
Application Number:
PCT/KR2013/007769
Publication Date:
October 23, 2014
Filing Date:
August 29, 2013
Export Citation:
Assignee:
NAT UNIV CHANGWON IND ACADEMY (KR)
International Classes:
A61K35/12; A61K8/99; A61P17/00; A61P29/00; A61Q19/02
Foreign References:
| KR100954138B1 | 2010-04-20 | |||
| US20060147430A1 | 2006-07-06 | |||
| KR20130021793A | 2013-03-06 | |||
| US20090304654A1 | 2009-12-10 |
Other References:
SEO, MI JEONG: "Hair growth promoting effect of culture medium of primary and immortalized adipose-derived stem cells", MASTER'S THESIS., 2011, pages 2 - 5
Attorney, Agent or Firm:
KIM, SOON WOONG (KR)
김순웅 (KR)
김순웅 (KR)
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