Title:
ANTI-KIT ANTIBODIES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/103165
Kind Code:
A3
Abstract:
Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.
Inventors:
HADARI YARON (US)
MANDEL-BAUSCH ELIZABETH M (US)
RADKE SUSANNE (US)
SCHLESSINGER JOSEPH (US)
SUZUKI YOSHIHISA (US)
MANDEL-BAUSCH ELIZABETH M (US)
RADKE SUSANNE (US)
SCHLESSINGER JOSEPH (US)
SUZUKI YOSHIHISA (US)
Application Number:
PCT/US2012/022471
Publication Date:
January 03, 2013
Filing Date:
January 25, 2012
Export Citation:
Assignee:
KOLLTAN PHARMACEUTICALS INC (US)
HADARI YARON (US)
MANDEL-BAUSCH ELIZABETH M (US)
RADKE SUSANNE (US)
SCHLESSINGER JOSEPH (US)
SUZUKI YOSHIHISA (US)
HADARI YARON (US)
MANDEL-BAUSCH ELIZABETH M (US)
RADKE SUSANNE (US)
SCHLESSINGER JOSEPH (US)
SUZUKI YOSHIHISA (US)
International Classes:
C07K16/28
Domestic Patent References:
| WO2008153926A2 | 2008-12-18 |
Foreign References:
| US20080260729A1 | 2008-10-23 | |||
| US20050244409A1 | 2005-11-03 | |||
| US20040248215A1 | 2004-12-09 | |||
| US20040018593A1 | 2004-01-29 | |||
| US20100173324A1 | 2010-07-08 | |||
| US20090181017A1 | 2009-07-16 | |||
| US20090169547A1 | 2009-07-02 |
Other References:
SCHITTEK, B. ET AL.: "Natural occurrence and origin of somatically mutated memory B cells in mice.", J. EXP. MED., vol. 176, 1 August 1992 (1992-08-01), pages 427 - 438, XP055114353
Attorney, Agent or Firm:
CORUZZI, Laura, A. et al. (222 East 41st StreetNew York, NY, US)
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