Title:
ANTI-KLB ANTIBODIES AND USES
Document Type and Number:
WIPO Patent Application WO/2023/046071
Kind Code:
A1
Abstract:
The present disclosure relates to anti-KLB antibodies and uses.
Inventors:
ZHANG LING (CN)
YING HUA (CN)
ZHANG MINGXI (CN)
JIN XINSHENG (CN)
TAO WEIKANG (CN)
YING HUA (CN)
ZHANG MINGXI (CN)
JIN XINSHENG (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2022/120887
Publication Date:
March 30, 2023
Filing Date:
September 23, 2022
Export Citation:
Assignee:
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K16/00; A61K39/00; A61K39/395; C07K16/28
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Other References:
MIN XIAOSHAN, WEISZMANN JENNIFER, JOHNSTONE SHEREE, WANG WEI, YU XINCHAO, ROMANOW WILLIAM, THIBAULT STEPHEN, LI YANG, WANG ZHULUN: "Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 293, no. 38, 1 September 2018 (2018-09-01), US , pages 14678 - 14688, XP055782479, ISSN: 0021-9258, DOI: 10.1074/jbc.RA118.004343
DATABASE Protein 1 December 2020 (2020-12-01), ANONYMOUS : "Chain H, 39F7 Fab heavy chain", XP093052620, retrieved from Genbank Database accession no. 5WI9_H
DATABASE Protein 1 December 2020 (2020-12-01), ANONYMOUS : "Chain L, 39F7 Fab light chain", XP093052624, retrieved from Genbank Database accession no. 5WI9_L
KUROSU, H. ET AL., J BIOL CHEM., vol. 282, 2007, pages 26687 - 95
KHARITONENKOV, A. ET AL., BIODRUGS., vol. 22, 2008, pages 37 - 44
ITOH ET AL., TREND GENET., vol. 20, 2004, pages 563 - 69
KHARITONENKOV ET AL., J CLIN INVEST., vol. 115, 2005, pages 1627 - 35
J. BIOL. CHEM., vol. 243, 1968, pages 3558
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
LEFRANC, M.P. ET AL., DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77
FRONT IMMUNOL., vol. 9, 16 October 2018 (2018-10-16), pages 2278
PROT. SCI., vol. 9, 2000, pages 487 - 496
YAZAKI, P.WU, A.M.: "Methods in Molecular Biology", vol. 248, 2004, HUMANA PRESS, pages: 255 - 268
Cold Spring Harbor Laboratory; "Uniprot", Database accession no. Q99N32
DATABASE Protein 1 December 2020 (2020-12-01), ANONYMOUS : "Chain H, 39F7 Fab heavy chain", XP093052620, retrieved from Genbank Database accession no. 5WI9_H
DATABASE Protein 1 December 2020 (2020-12-01), ANONYMOUS : "Chain L, 39F7 Fab light chain", XP093052624, retrieved from Genbank Database accession no. 5WI9_L
KUROSU, H. ET AL., J BIOL CHEM., vol. 282, 2007, pages 26687 - 95
KHARITONENKOV, A. ET AL., BIODRUGS., vol. 22, 2008, pages 37 - 44
ITOH ET AL., TREND GENET., vol. 20, 2004, pages 563 - 69
KHARITONENKOV ET AL., J CLIN INVEST., vol. 115, 2005, pages 1627 - 35
J. BIOL. CHEM., vol. 243, 1968, pages 3558
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
LEFRANC, M.P. ET AL., DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77
FRONT IMMUNOL., vol. 9, 16 October 2018 (2018-10-16), pages 2278
PROT. SCI., vol. 9, 2000, pages 487 - 496
YAZAKI, P.WU, A.M.: "Methods in Molecular Biology", vol. 248, 2004, HUMANA PRESS, pages: 255 - 268
Cold Spring Harbor Laboratory; "Uniprot", Database accession no. Q99N32
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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