Title:
ANTI-LAMP5 ANTIBODY AND UTILIZATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/147153
Kind Code:
A1
Abstract:
A monoclonal antibody recognizing the extracellular region of LAMP5. This antibody exhibits, on a multiple myeloma cell line, an antibody-dependent cell-mediated cytotoxic activity and/or a cell proliferation depressing activity in the presence of a toxin-labeled secondary antibody.
Inventors:
KAWAI SHIGETO (JP)
Application Number:
PCT/JP2013/059516
Publication Date:
October 03, 2013
Filing Date:
March 29, 2013
Export Citation:
Assignee:
FORERUNNER PHARMA RES CO LTD (JP)
International Classes:
C12N15/09; A61K39/395; A61P35/00; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
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BAD-LAMP: "defines a subset of early endocytic organelles in subpopulations of cortical projection neurons", J. CELL SCI., vol. 120, 2007, pages 353 - 65
BAD-LAMP: "is a novel biomarker of nonactivated human plasmacytoid dendritic cells", BLOOD, vol. 118, 2011, pages 609 - 17, XP055171209, DOI: doi:10.1182/blood-2010-11-319699
"The plasmacytoid monocyte/interferon producing cells", VIRCHOWS ARCH., vol. 443, 2003, pages 703 - 17
"Novel markers of normal and neoplastic human plasmacytoid dendritic cells", BLOOD, vol. 111, 2008, pages 3778 - 92
"Intracellular trafficking of lysosomal membrane proteins", BIOASSAYS, vol. 18, 1996, pages 379 - 89
"Lysosomal membrane glycoproteins: structure, biosynthesis and intracellular trafficking", J. BIOL. CHEM., vol. 266, 1991, pages 21327 - 30
"Expression of Lamp-1 and Lamp-2 and their interactions with galectin-3 in human tumor cells", INT. J. CANCER, vol. 75, 1998, pages 105 - 11
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY, pages: 359 - 420
SAMBROOK, J. ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRESS, pages: 9.47 - 9.58
J. IMMUNOL., vol. 123, no. 4, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
C. EUR. J. IMMUNOL., vol. 6, no. 7, 1976, pages 511 - 519
CELL, vol. 8, no. 3, 1976, pages 405 - 415
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VANDAMME ET AL., EUR. J. BIOCHEM., vol. 192, no. 3, 1990, pages 767 - 775
BIOCHEMISTRY, vol. 18, no. 24, 1979, pages 5294 - 5299
ANAL. BIOCHEM., vol. 162, no. 1, 1987, pages 156 - 159
PROC. NATL. ACAD. SCI. USA, vol. 85, no. 23, 1988, pages 8998 - 9002
NUCLEIC ACIDS RES., vol. 17, no. 8, 1989, pages 2919 - 2932
BIO/TECHNOLOGY, vol. 12, no. 7, 1994, pages 699 - 702
CANCER RES., vol. 53, 1993, pages 851 - 856
BERNASCONI ET AL., SCIENCE, vol. 298, 2002, pages 2199 - 2202
"Sequences of Proteins of Immunological Interest", 1987, NATIONAL INSTITUTE OF HEALTH
KUNKEL ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488 - 492
ANNU. REV. BIOPHYS. BIOMOL. STRUCT., vol. 35, 2006, pages 225 - 249
PROC. NATL. ACAD. SCI. USA, vol. 100, no. 11, 2003, pages 6353 - 6357
"Current Protocols in Immunology", 1993, JOHN WILEY & SONS, INC., article "Immunologic studies in humans"
J. BIOL. CHEM., vol. 278, 2003, pages 3466 - 3473
J. PHARM. SCI., vol. 83, no. 12, 1994, pages 1670 - 1675
J. CLIN. INVEST., vol. 108, no. 11, 2001, pages 1687 - 95
ANAL. BIOCHEM., vol. 230, no. 2, 1995, pages 229 - 238
LANGONE, J. J. ET AL., METHODS IN ENZYMOLOGY, vol. 93, 1983, pages 307 - 308
NATURE MEDICINE, vol. 2, 1996, pages 350 - 353
FULTON, R.J. ET AL., J. BIOL. CHEM., vol. 261, 1986, pages 5314 - 5319
SIVAM, G. ET AL., CANCER RES., vol. 47, 1987, pages 3169 - 3173
CUMBER A. J. ET AL., J. IMMUNOL. METHODS, vol. 135, 1990, pages 15 - 24
WAWRZYNCZAK E. J. ET AL., CANCER RES., vol. 50, 1990, pages 7519 - 7562
GHEEITE V. ET AL., J. IMMUNOL. METHODS, vol. 142, 1991, pages 223 - 230
THORPE, P.E. ET AL., CANCER RES., vol. 47, 1987, pages 5924 - 5931
WAWRZYNCZAK E. J. ET AL., BR. J. CANCER, vol. 66, 1992, pages 361 - 366
SIVAM G. ET AL., CANCER RES, vol. 47, 1987, pages 3169 - 3173
CUMBER, A. J. ET AL., J. IMMUNOL. METHODS, vol. 135, 1990, pages 15 - 24
BOLOGNESI, A. ET AL., CLIN. EXP. IMMUNOL., vol. 89, 1992, pages 341 - 346
STIRPE, F.; BARBIERI, L., FEBS LETTERS, vol. 195, 1986, pages 1 - 8
CASELLAS, P. ET AL., EUR. J. BIOCHEM., vol. 176, 1988, pages 581 - 588
CORBI ET AL., EUR. J. CARDIOTHERAC. SURG., vol. 18, no. 1, 2000, pages 98 - 103
KADO ET AL., ACTA DIABETOL., 1999, pages 67 - 72
CHEBATH ET AL., EUR. CYTOKINE NETW., 1997, pages 359 - 365
KOLLET ET AL., BLOOD, vol. 94, no. 3, 1999, pages 923 - 31
AUSUBEL ET AL.: "Current Protocols in Molecular Biology, Supra", 1987, INTERSCIENCE, pages: 6.3 - 6.4
SAMBROOK, J.C.; FRITSCH, E. F.; MANIATIS, T.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Initial genome sequencing and analysis of multiple myeloma", NATURE, vol. 471, 2011, pages 467 - 72
"Enforced and prolonged CD40 ligand expression triggers antibody production in vivo", EUR. J. IMMUNOL., vol. 31, 2001, pages 3484 - 92
"Synergistic antibody induction by antigen - CD40 ligand fusion protein as improved immunogen", IMMUNOLOGY, vol. 115, 2005, pages 215 - 22
See also references of EP 2832856A4
BAD-LAMP: "defines a subset of early endocytic organelles in subpopulations of cortical projection neurons", J. CELL SCI., vol. 120, 2007, pages 353 - 65
BAD-LAMP: "is a novel biomarker of nonactivated human plasmacytoid dendritic cells", BLOOD, vol. 118, 2011, pages 609 - 17, XP055171209, DOI: doi:10.1182/blood-2010-11-319699
"The plasmacytoid monocyte/interferon producing cells", VIRCHOWS ARCH., vol. 443, 2003, pages 703 - 17
"Novel markers of normal and neoplastic human plasmacytoid dendritic cells", BLOOD, vol. 111, 2008, pages 3778 - 92
"Intracellular trafficking of lysosomal membrane proteins", BIOASSAYS, vol. 18, 1996, pages 379 - 89
"Lysosomal membrane glycoproteins: structure, biosynthesis and intracellular trafficking", J. BIOL. CHEM., vol. 266, 1991, pages 21327 - 30
"Expression of Lamp-1 and Lamp-2 and their interactions with galectin-3 in human tumor cells", INT. J. CANCER, vol. 75, 1998, pages 105 - 11
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY, pages: 359 - 420
SAMBROOK, J. ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRESS, pages: 9.47 - 9.58
J. IMMUNOL., vol. 123, no. 4, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
C. EUR. J. IMMUNOL., vol. 6, no. 7, 1976, pages 511 - 519
CELL, vol. 8, no. 3, 1976, pages 405 - 415
NATURE, vol. 276, no. 5685, 1978, pages 269 - 270
J. IMMUNOL. METHODS, vol. 35, no. 1-2, 1980, pages 1 - 21
J. EXP. MED., vol. 148, no. 1, 1978, pages 313 - 323
NATURE, vol. 277, no. 5692, 1979, pages 131 - 133
KOHLER; MILLSTEIN, METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
VANDAMME ET AL., EUR. J. BIOCHEM., vol. 192, no. 3, 1990, pages 767 - 775
BIOCHEMISTRY, vol. 18, no. 24, 1979, pages 5294 - 5299
ANAL. BIOCHEM., vol. 162, no. 1, 1987, pages 156 - 159
PROC. NATL. ACAD. SCI. USA, vol. 85, no. 23, 1988, pages 8998 - 9002
NUCLEIC ACIDS RES., vol. 17, no. 8, 1989, pages 2919 - 2932
BIO/TECHNOLOGY, vol. 12, no. 7, 1994, pages 699 - 702
CANCER RES., vol. 53, 1993, pages 851 - 856
BERNASCONI ET AL., SCIENCE, vol. 298, 2002, pages 2199 - 2202
"Sequences of Proteins of Immunological Interest", 1987, NATIONAL INSTITUTE OF HEALTH
KUNKEL ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488 - 492
ANNU. REV. BIOPHYS. BIOMOL. STRUCT., vol. 35, 2006, pages 225 - 249
PROC. NATL. ACAD. SCI. USA, vol. 100, no. 11, 2003, pages 6353 - 6357
"Current Protocols in Immunology", 1993, JOHN WILEY & SONS, INC., article "Immunologic studies in humans"
J. BIOL. CHEM., vol. 278, 2003, pages 3466 - 3473
J. PHARM. SCI., vol. 83, no. 12, 1994, pages 1670 - 1675
J. CLIN. INVEST., vol. 108, no. 11, 2001, pages 1687 - 95
ANAL. BIOCHEM., vol. 230, no. 2, 1995, pages 229 - 238
LANGONE, J. J. ET AL., METHODS IN ENZYMOLOGY, vol. 93, 1983, pages 307 - 308
NATURE MEDICINE, vol. 2, 1996, pages 350 - 353
FULTON, R.J. ET AL., J. BIOL. CHEM., vol. 261, 1986, pages 5314 - 5319
SIVAM, G. ET AL., CANCER RES., vol. 47, 1987, pages 3169 - 3173
CUMBER A. J. ET AL., J. IMMUNOL. METHODS, vol. 135, 1990, pages 15 - 24
WAWRZYNCZAK E. J. ET AL., CANCER RES., vol. 50, 1990, pages 7519 - 7562
GHEEITE V. ET AL., J. IMMUNOL. METHODS, vol. 142, 1991, pages 223 - 230
THORPE, P.E. ET AL., CANCER RES., vol. 47, 1987, pages 5924 - 5931
WAWRZYNCZAK E. J. ET AL., BR. J. CANCER, vol. 66, 1992, pages 361 - 366
SIVAM G. ET AL., CANCER RES, vol. 47, 1987, pages 3169 - 3173
CUMBER, A. J. ET AL., J. IMMUNOL. METHODS, vol. 135, 1990, pages 15 - 24
BOLOGNESI, A. ET AL., CLIN. EXP. IMMUNOL., vol. 89, 1992, pages 341 - 346
STIRPE, F.; BARBIERI, L., FEBS LETTERS, vol. 195, 1986, pages 1 - 8
CASELLAS, P. ET AL., EUR. J. BIOCHEM., vol. 176, 1988, pages 581 - 588
CORBI ET AL., EUR. J. CARDIOTHERAC. SURG., vol. 18, no. 1, 2000, pages 98 - 103
KADO ET AL., ACTA DIABETOL., 1999, pages 67 - 72
CHEBATH ET AL., EUR. CYTOKINE NETW., 1997, pages 359 - 365
KOLLET ET AL., BLOOD, vol. 94, no. 3, 1999, pages 923 - 31
AUSUBEL ET AL.: "Current Protocols in Molecular Biology, Supra", 1987, INTERSCIENCE, pages: 6.3 - 6.4
SAMBROOK, J.C.; FRITSCH, E. F.; MANIATIS, T.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Initial genome sequencing and analysis of multiple myeloma", NATURE, vol. 471, 2011, pages 467 - 72
"Enforced and prolonged CD40 ligand expression triggers antibody production in vivo", EUR. J. IMMUNOL., vol. 31, 2001, pages 3484 - 92
"Synergistic antibody induction by antigen - CD40 ligand fusion protein as improved immunogen", IMMUNOLOGY, vol. 115, 2005, pages 215 - 22
See also references of EP 2832856A4
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
Patent business corporation cent Crest international patent firm (JP)
Patent business corporation cent Crest international patent firm (JP)
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