Title:
ANTI-NC1 MONOCLONAL ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2005/082940
Kind Code:
A1
Abstract:
It is intended to detect nephritis, either primary or secondary, at the early stage with the use of an anti-NC1 monoclonal antibody. Namely, data useful in diagnosing kidney functions can be provided by immunostaining a kidney biopsy sample at the early stage, wherein immunoglobulin never undergoes deposition in glomerulus or the like, and finding NC1 via an antigen-antibody reaction in a sample such as urine or serum. Further, it is intended to apply the above antibody to therapy.
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Inventors:
YOKOYAMA TSUKAO (JP)
IMASAWA TOSHIYUKI (JP)
IMASAWA TOSHIYUKI (JP)
Application Number:
PCT/JP2005/002669
Publication Date:
September 09, 2005
Filing Date:
February 15, 2005
Export Citation:
Assignee:
YOKOYAMA TSUKAO (JP)
IMASAWA TOSHIYUKI (JP)
IMASAWA TOSHIYUKI (JP)
International Classes:
C07K16/18; C12P21/08; G01N33/53; G01N33/577; (IPC1-7): C07K16/18; G01N33/53; G01N33/577; C12P21/08
Domestic Patent References:
| WO2002085924A2 | 2002-10-31 |
Foreign References:
| US5593900A | 1997-01-14 |
Other References:
NINOMIYA Y. ET AL: "Differential expressionof two basement membrane collagen genes. COL4A6 and COL4A5, demostrated by immunofluorescence staining using peptide-specific monoclonal antibodies.", THE JOURNAL OF CELL BIOLOGY., vol. 130, no. 5, September 1995 (1995-09-01), pages 1219 - 1229, XP008071041
SUGIHARA K. ET AL: "Experimental anti-GBM glomerulonephritis induced in rats by immunization with synthetic peptides based on six alpha chains on human type IV collagen.", JOURNAL OF PATHOLOGY., vol. 178, no. 3, March 1996 (1996-03-01), pages 352 - 358, XP008071043
YOKOYAMA K. ET AL: "Type IV Collagen no NCI Ryoiki (K35) ni yori Yudo saseru Jin'en Model.", THE CELL., vol. 34, no. 4, 20 April 2002 (2002-04-20), pages 36 - 39, XP008084480
YOKOYAMA K. ET AL: "Nyo to Kessei ni Okeru NCI (Type IV Collagen NC1 Ryoiki) to Ko NC1 Kotai no Sokutei.", THE CELL., vol. 35, no. 4, 20 April 2003 (2003-04-20), pages 40 - 44, XP008084481
NINOMIYA ET AL., JCB, vol. 130, no. 5, 1995, pages 1219 - 1229
SUGIHARA ET AL., J. PATH., vol. 178, no. 3, 1996, pages 352 - 358
KISHIRO ET AL., CELL STRUC. AND FUNC., vol. 20, no. 2, 1995, pages 151 - 156
DING ET AL., CHINESE MEDICAL J., vol. 110, no. 8, 1997, pages 584 - 586
JOHANSSON ET AL., CONNECTIVE TISSUE RESEARCH, vol. 25, no. 3-4, 1991, pages 229 - 241
HIRATA ET AL., J.PATH., vol. 177, no. 4, 1995, pages 407 - 413,586
KLEPPEL ET AL., AMERICAN J.PATH., vol. 134, no. 4, 1989, pages 813 - 825
See also references of EP 1712564A4
SUGIHARA K. ET AL: "Experimental anti-GBM glomerulonephritis induced in rats by immunization with synthetic peptides based on six alpha chains on human type IV collagen.", JOURNAL OF PATHOLOGY., vol. 178, no. 3, March 1996 (1996-03-01), pages 352 - 358, XP008071043
YOKOYAMA K. ET AL: "Type IV Collagen no NCI Ryoiki (K35) ni yori Yudo saseru Jin'en Model.", THE CELL., vol. 34, no. 4, 20 April 2002 (2002-04-20), pages 36 - 39, XP008084480
YOKOYAMA K. ET AL: "Nyo to Kessei ni Okeru NCI (Type IV Collagen NC1 Ryoiki) to Ko NC1 Kotai no Sokutei.", THE CELL., vol. 35, no. 4, 20 April 2003 (2003-04-20), pages 40 - 44, XP008084481
NINOMIYA ET AL., JCB, vol. 130, no. 5, 1995, pages 1219 - 1229
SUGIHARA ET AL., J. PATH., vol. 178, no. 3, 1996, pages 352 - 358
KISHIRO ET AL., CELL STRUC. AND FUNC., vol. 20, no. 2, 1995, pages 151 - 156
DING ET AL., CHINESE MEDICAL J., vol. 110, no. 8, 1997, pages 584 - 586
JOHANSSON ET AL., CONNECTIVE TISSUE RESEARCH, vol. 25, no. 3-4, 1991, pages 229 - 241
HIRATA ET AL., J.PATH., vol. 177, no. 4, 1995, pages 407 - 413,586
KLEPPEL ET AL., AMERICAN J.PATH., vol. 134, no. 4, 1989, pages 813 - 825
See also references of EP 1712564A4
Attorney, Agent or Firm:
Yoshioka, Takuji (Kiyose-shi, Tokyo, JP)
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