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Title:
ANTI-NOROVIRUS ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2022/244860
Kind Code:
A1
Abstract:
Disclosed is an anti-norovirus antibody that responds to noroviruses of a number of genotypes and enables comprehensive detection of noroviruses. This anti-norovirus antibody or an antigen-binding fragment thereof undergoes an antigen-antibody reaction with each of peptides respectively having the amino acid sequences represented by SEQ ID NO: 1 and SEQ ID NO: 2. Provided are: the novel anti-norovirus antibody that binds broadly to noroviruses and enables specific and high-sensitive detection of a wide range of human noroviruses; and a norovirus immunoassay method and a norovirus immunoassay instrument using the same.

Inventors:
SAITO YUJI (JP)
HIRAOKA KOJI (JP)
OGASAWARA SHINYA (JP)
Application Number:
PCT/JP2022/020944
Publication Date:
November 24, 2022
Filing Date:
May 20, 2022
Export Citation:
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Assignee:
DENKA COMPANY LTD (JP)
International Classes:
C12N15/13; C07K16/10; C12M1/34; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/08; C12Q1/02; G01N33/569
Domestic Patent References:
WO2020036135A12020-02-20
WO2013039165A12013-03-21
Foreign References:
JP2009542715A2009-12-03
Other References:
HANSMAN, G. S. ET AL.: "Genetic and antigenic diversity among noroviruses.", JOURNAL OF GENERAL VIROLOGY, vol. 87, 2006, pages 909 - 919, XP055057980
XU MENG, LU FEIFENG, LYU CHENANG, WU QINGPING, ZHANG JUMEI, TIAN PENG, XUE LIANG, XU TING, WANG DAPENG: "Broad-range and effective detection of human noroviruses by colloidal gold immunochromatographic assay based on the shell domain of the major capsid protein", BMC MICROBIOLOGY., vol. 21, no. 22, 11 January 2021 (2021-01-11), pages 1 - 10, XP093007629
LI X; ZHOU R; WANG Y; SHENG H; TIAN X; LI H; QIU H: "Identification and characterization of a native epitope common to norovirus strains GII/4, GII/7 and GII/8.", VIRUS RESEARCH., vol. 140, 2009, pages 188 - 193, XP025991657
PARRA GABRIEL I., AZURE JOLYNN, FISCHER RENATE, BOK KARIN, SANDOVAL-JAIME CARLOS, SOSNOVTSEV STANISLAV V., SANDER PETER, GREEN KIM: "Identification of a Broadly Cross-Reactive Epitope in the Inner Shell of the Norovirus Capsid", PLOS ONE, vol. 8, no. 6, 2013, pages 1 - 7, XP055852704
"Evaluation of an improved norovirus antigen detection EIA kit", JAPANESE JOURNAL OF MEDICINE AND PHARMACEUTICAL SCIENCE, vol. 61, no. 1, 25 January 2009 (2009-01-25), pages 93 - 98
"Evaluation of the QuickNavi-Noro quick norovirus antigen diagnosing agent", JAPANESE JOURNAL OF MEDICINE AND PHARMACEUTICAL SCIENCE, vol. 61, no. 5, 25 May 2009 (2009-05-25), pages 779 - 785
GABRIEL I. PARRA ET AL., PLOS ONE, vol. 8, June 2013 (2013-06-01), pages 67592
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495 - 497
JOSEPHY P.D.MASON R.P. ET AL., J. BIOL. CHEM., vol. 257, 1982, pages 3669 - 3675
Attorney, Agent or Firm:
TANIGAWA AND PARTNERS, PATENT FIRM (JP)
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