Title:
ANTI-PD-1 ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2018/034226
Kind Code:
A1
Abstract:
Provided is an anti-PD-1 antibody that can be administered frequently even to animals other than rats. An anti-PD-1 antibody including: (a) an L chain that has an L chain variable region including CDR1 having the amino acid sequence of QSLEYSDGYTY (SEQ ID NO: 16), CDR2 having the amino acid sequence of GVS, and CDR3 having the amino acid sequence of FQATHDPDT (SEQ ID NO: 17), and also has an L chain constant region of an animal antibody other than rat; and (b) an H chain that has an H chain variable region including CDR1 having the amino acid sequence of GFSLTSYY (SEQ ID NO: 18), CDR2 having the amino acid sequence of IRSGGST (SEQ ID NO: 19), and CDR3 having the amino acid sequence of ARTSSGYEGGFDY (SEQ ID NO: 20), and also has an H chain constant region of an animal antibody other than rat. A pharmaceutical composition containing the anti-PD-1 antibody as an active ingredient. Also provided is a method for producing the anti-PD-1 antibody.
Inventors:
KONNAI SATORU (JP)
OHASHI KAZUHIKO (JP)
MURATA SHIRO (JP)
OKAGAWA TOMOHIRO (JP)
NISHIMORI ASAMI (JP)
MAEKAWA NAOYA (JP)
SUZUKI YASUHIKO (JP)
NAKAJIMA CHIE (JP)
OHASHI KAZUHIKO (JP)
MURATA SHIRO (JP)
OKAGAWA TOMOHIRO (JP)
NISHIMORI ASAMI (JP)
MAEKAWA NAOYA (JP)
SUZUKI YASUHIKO (JP)
NAKAJIMA CHIE (JP)
Application Number:
PCT/JP2017/029056
Publication Date:
February 22, 2018
Filing Date:
August 10, 2017
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C12N15/09; A61K39/395; A61P31/00; A61P35/00; C07K16/18; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Foreign References:
| JP2015509091A | 2015-03-26 |
Other References:
2013 FISCAL YEAR ANNUAL RESEARCH REPORT USHI NO MEN'EKI YOKUSEI JUYOTAI NO KINO KAISEKI OYOBI NANJISEI SHIPPEI NO SHINKI SEIGYOHO ENO OYO KENKYU, 25 June 2015 (2015-06-25), XP055465836, Retrieved from the Internet
IKEBUCHI, R. ET AL.: "Blockade of bovine PD-1 increases T cell function and inhibits bovine leukemia virus expression in B cells in vitro", VETERINARY RESEARCH, vol. 44, no. 59, 2013, pages 1 - 15, XP021156070
IKEBUCHI, R. ET AL.: "Influence of PD-L1 cross- linking on cell death in PD-L1-expressing cell lines and bovine lymphocytes", IMMUNOLOGY, vol. 142, 2014, pages 551 - 561, XP055464737
See also references of EP 3498839A4
IKEBUCHI, R. ET AL.: "Blockade of bovine PD-1 increases T cell function and inhibits bovine leukemia virus expression in B cells in vitro", VETERINARY RESEARCH, vol. 44, no. 59, 2013, pages 1 - 15, XP021156070
IKEBUCHI, R. ET AL.: "Influence of PD-L1 cross- linking on cell death in PD-L1-expressing cell lines and bovine lymphocytes", IMMUNOLOGY, vol. 142, 2014, pages 551 - 561, XP055464737
See also references of EP 3498839A4
Attorney, Agent or Firm:
MAYAMA, Setsuko et al. (JP)
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