Title:
ANTI-PD-1 MONOCLONAL ANTIBODY, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/137576
Kind Code:
A1
Abstract:
An anti-human PD-1 monoclonal antibody, and a preparation method therefor and an application thereof. The anti-human PD-1 monoclonal antibody has good bioactivity, can effectively bind with an extracellular region of a human PD-1 protein receptor, and can effectively seal PD-1 protein at protein level and cellular level and block the binding of the PD-1 protein with a ligand PD-L1, thereby effectively enhancing immunity. The monoclonal antibody can be applied independently or jointly with other antitumor drugs to tumor immunotherapy and the diagnosis and screening of patients with PD-L1 positive tumors; and the monoclonal antibody has a promising prospect in the preparation of drugs for treating tumors, resisting autoimmune diseases and the like.
Inventors:
ZHAO JIE (CN)
GAO HONGHAI (CN)
GUO JINLIN (CN)
DANG WEI (CN)
ZHU LINGQIAO (CN)
ZHANG CHENGHAI (CN)
ZHAO LE (CN)
CHEN JIANHE (CN)
HUANG HAOMIN (CN)
ZHU ZHENPING (CN)
GAO HONGHAI (CN)
GUO JINLIN (CN)
DANG WEI (CN)
ZHU LINGQIAO (CN)
ZHANG CHENGHAI (CN)
ZHAO LE (CN)
CHEN JIANHE (CN)
HUANG HAOMIN (CN)
ZHU ZHENPING (CN)
Application Number:
PCT/CN2018/073575
Publication Date:
August 02, 2018
Filing Date:
January 22, 2018
Export Citation:
Assignee:
SUNSHINE GUOJIAN PHARMACEUTICAL SHANGHAI CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P31/00; A61P35/00; A61P37/04; C12N15/13
Domestic Patent References:
| WO2013169693A1 | 2013-11-14 | |||
| WO2014194302A2 | 2014-12-04 | |||
| WO2015112900A1 | 2015-07-30 |
Foreign References:
| CN105330740A | 2016-02-17 | |||
| CN106336460A | 2017-01-18 | |||
| CN106008714A | 2016-10-12 |
Other References:
BLANK ET AL., CANCER IMMUNOTHERAPY, vol. 54, 2005, pages 307 - 314
ZHANG, X. ET AL., IMMUNITY, vol. 20, 2004, pages 337 - 347
LIN ET AL., PROC.NATL.ACAD.SCI.USA, vol. 105, 2008, pages 3011 - 6
IWAI Y. ET AL., PROC.NATL.ACAD.SCI.U.S.A., vol. 99, 2002, pages 12293 - 12297
STROME S.E. ET AL., CANCER RES., vol. 63, 2003, pages 6501 - 6505
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Refer to Current Protocols in Molecular Biology", vol. 1
See also references of EP 3575322A4
ZHANG, X. ET AL., IMMUNITY, vol. 20, 2004, pages 337 - 347
LIN ET AL., PROC.NATL.ACAD.SCI.USA, vol. 105, 2008, pages 3011 - 6
IWAI Y. ET AL., PROC.NATL.ACAD.SCI.U.S.A., vol. 99, 2002, pages 12293 - 12297
STROME S.E. ET AL., CANCER RES., vol. 63, 2003, pages 6501 - 6505
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Refer to Current Protocols in Molecular Biology", vol. 1
See also references of EP 3575322A4
Attorney, Agent or Firm:
LECOME INTELLECTUAL PROPERTY AGENT LTD. (CN)
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