Title:
ANTI-PD-L1 ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/068775
Kind Code:
A1
Abstract:
Provided in the present invention are a PD-L1 antibody and a use thereof; the antibody or an active fragment thereof does not block the binding of PD-1 with PD-L1, and specifically targets the IgC-like region of PD-L1. The non-blocking PD-L1 antibody of the present invention can circumvent SPD-L1 to the maximum extent, and has the activity of inducing ADCC/CDC functional effects whilst also having excellent anti-tumour activity.
Inventors:
ZHOU JUN (CN)
Application Number:
PCT/CN2021/121022
Publication Date:
April 07, 2022
Filing Date:
September 27, 2021
Export Citation:
Assignee:
FUNWICK BIOMEDICAL TECH KUNSHAN CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P31/06; A61P31/14; A61P31/18; A61P31/20; A61P35/00; C07K16/46; C12N15/13; C12N15/62; C12N15/63; G01N33/577
Foreign References:
| CN110891975A | 2020-03-17 | |||
| CN108350082A | 2018-07-31 | |||
| CN107488229A | 2017-12-19 | |||
| CN105461808A | 2016-04-06 | |||
| CN104356236A | 2015-02-18 |
Other References:
KABAT ET AL.: "NIH Publ. No.91-3242", vol. I, 1991, pages: 647 - 669
SAMBROOK ET AL.: "Molecule Clone: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
SAMBROOK ET AL.: "Molecule Clone: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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