Title:
ANTI-PD1 MONOCLONAL ANTIBODY, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/036472
Kind Code:
A1
Abstract:
An anti-PD1 (programmed cell death 1) monoclonal antibody or an antigen-binding fragment thereof, a pharmaceutical composition thereof and use thereof. The heavy chain variable region of the monoclonal antibody comprises CDRs (complementary determining region) of amino acid sequences as shown in SEQ ID NO:9-11; and/or the light chain variable region of the monoclonal antibody comprises CDRs of amino acid sequences as shown in SEQ ID NO:12-14. The monoclonal antibody can bind to PD1 specifically, relieve immunosuppression of PD1 on an organism specifically and activate T lymphocytes.
Inventors:
LI BAIYONG (CN)
XIA YU (CN)
WANG ZHONGMIN MAXWELL (CN)
ZHANG PENG (CN)
XIA YU (CN)
WANG ZHONGMIN MAXWELL (CN)
ZHANG PENG (CN)
Application Number:
PCT/CN2017/098465
Publication Date:
March 01, 2018
Filing Date:
August 22, 2017
Export Citation:
Assignee:
AKESO BIOPHARMA INC (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; A61P35/02; C12N5/20; C12N15/13; G01N33/577; G01N33/68
Domestic Patent References:
| WO2015112800A1 | 2015-07-30 |
Foreign References:
| CN106977602A | 2017-07-25 | |||
| CN106967172A | 2017-07-21 | |||
| CN105175544A | 2015-12-23 | |||
| CN105175545A | 2015-12-23 | |||
| CN104250302A | 2014-12-31 | |||
| CN104936982A | 2015-09-23 | |||
| CN102264762A | 2011-11-30 | |||
| CN103608040A | 2014-02-26 | |||
| US4816567A | 1989-03-28 | |||
| US8008449B2 | 2011-08-30 |
Other References:
ISAI ET AL., J.EXP.MED., vol. 198, 2003, pages 39 - 50
HAMANISHI ET AL., PROC.NATL.ACAD.SCI.USA, vol. 104, 2007, pages 3360 - 5
HOMET M.B.; PARISI G. ET AL.: "Anti-PDl Therapy in Melanoma", SEMIN ONCOL., vol. 42, no. 3, June 2015 (2015-06-01), pages 466 - 473
HEINE A ET AL.: "Advances in immunotherapy of chronic myeloid leukemia CML", CURR CANCER DRUG TARGETS, vol. 13, no. 7, September 2013 (2013-09-01), pages 768 - 74
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NIH
SCHOENBORN JR; WILSON CB: "Regulation of Interferon-y During Innate and Adaptive Immune Responses", ADVANCES IN IMMUNOLOGY, vol. 96, 2007, pages 41 - 101
CHAVEZ, A.R. ET AL.: "Pharmacologic administration of interleukin-2", ANN N Y ACAD SCI, vol. 1182, 2009, pages 14 - 27
KABAT: "Sequences of Proteins of Immunological Interest", NATIONAL INSTITUTES OF HEALTH BETHESDA, 1987
CHOTHIA; LESK, MOL. BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 878 - 883
"Fundamental Immunology", 1989, RAVEN PRESS
HOLLIGER P. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
POLJAK R. J. ET AL., STRUCTURE, vol. 2, 1994, pages 1121 - 1123
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
REICHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 329
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
CLARK, IMMUNOL. TODAY, vol. 21, 2000, pages 397 - 402
"Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING COMPANY
J SAMBROOK ET AL.: "Guide to Molecular Cloning", SCIENCE PRESS
STEWART, S.J.: "Basic Methods in antibody Production and Characterization", 2000, CRC PRESS, article "Monoclonal Antibody Production"
SHINOHARA T ET AL.: "Structure and chromosomal localization of the human PD1 gene (PDCD1", GENOMICS, vol. 23, no. 3, 1995, pages 704 - 6, XP024796771, DOI: doi:10.1006/geno.1994.1562
See also references of EP 3505535A4
HAMANISHI ET AL., PROC.NATL.ACAD.SCI.USA, vol. 104, 2007, pages 3360 - 5
HOMET M.B.; PARISI G. ET AL.: "Anti-PDl Therapy in Melanoma", SEMIN ONCOL., vol. 42, no. 3, June 2015 (2015-06-01), pages 466 - 473
HEINE A ET AL.: "Advances in immunotherapy of chronic myeloid leukemia CML", CURR CANCER DRUG TARGETS, vol. 13, no. 7, September 2013 (2013-09-01), pages 768 - 74
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NIH
SCHOENBORN JR; WILSON CB: "Regulation of Interferon-y During Innate and Adaptive Immune Responses", ADVANCES IN IMMUNOLOGY, vol. 96, 2007, pages 41 - 101
CHAVEZ, A.R. ET AL.: "Pharmacologic administration of interleukin-2", ANN N Y ACAD SCI, vol. 1182, 2009, pages 14 - 27
KABAT: "Sequences of Proteins of Immunological Interest", NATIONAL INSTITUTES OF HEALTH BETHESDA, 1987
CHOTHIA; LESK, MOL. BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 878 - 883
"Fundamental Immunology", 1989, RAVEN PRESS
HOLLIGER P. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
POLJAK R. J. ET AL., STRUCTURE, vol. 2, 1994, pages 1121 - 1123
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
REICHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 329
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
CLARK, IMMUNOL. TODAY, vol. 21, 2000, pages 397 - 402
"Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING COMPANY
J SAMBROOK ET AL.: "Guide to Molecular Cloning", SCIENCE PRESS
STEWART, S.J.: "Basic Methods in antibody Production and Characterization", 2000, CRC PRESS, article "Monoclonal Antibody Production"
SHINOHARA T ET AL.: "Structure and chromosomal localization of the human PD1 gene (PDCD1", GENOMICS, vol. 23, no. 3, 1995, pages 704 - 6, XP024796771, DOI: doi:10.1006/geno.1994.1562
See also references of EP 3505535A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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