Title:
ANTI-PODOCALYXIN ANTIBODY THAT TARGETS TUMOR MICROENVIRONMENT
Document Type and Number:
WIPO Patent Application WO/2017/168726
Kind Code:
A1
Abstract:
The present invention provides an anti-podocalyxin antibody that targets a tumor microenvironment or an antigen-binding fragment of the antibody.
Inventors:
KATO YUKINARI (JP)
KATO MIKA (JP)
OGASAWARA SATOSHI (JP)
KATO MIKA (JP)
OGASAWARA SATOSHI (JP)
Application Number:
PCT/JP2016/060822
Publication Date:
October 05, 2017
Filing Date:
March 31, 2016
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
C07K16/32; A61K39/395; A61P35/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09
Domestic Patent References:
| WO2015058301A1 | 2015-04-30 | |||
| WO2016013597A1 | 2016-01-28 | |||
| WO2002031140A1 | 2002-04-18 |
Foreign References:
| JP2016508219A | 2016-03-17 |
Other References:
SNYDER KIMBERLY A ET AL.: "Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy", BREAST CANCER RESEARCH, vol. 17, no. 46, 2015, pages 1 - 14, XP021221754
TESTA JACQUELINE E. ET AL.: "Ubiquitous yet Distinct Expression of Podocalyxin on Vascular Surfaces in Normal and Tumor Tissues in the Rat", JOURNAL OF VASCULAR RESEARCH, vol. 46, 2009, pages 311 - 324, XP055548089
SCHOPPERLE W. MICHAEL ET AL.: "Human embryonal carcinoma tumor antigen, Gp200/GCTM-2, is podocalyxin", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 300, no. 2, January 2003 (2003-01-01), pages 285 - 290, XP002538479
BUGANIM YOSEF ET AL.: "Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression", CARCINOGENESIS, vol. 32, no. 12, 2011, pages 1749 - 1757, XP055425851
BARDERAS RODRIGO ET AL.: "In-depth Characterization of the Secretome of Colorectal Cancer Metastatic Cells Identifies Key Proteins in Cell Adhesion, Migration, and Invasion", MOLECULAR & CELLULAR PROTEOMICS, vol. 12, no. 6, June 2013 (2013-06-01), pages 1602 - 1620, XP055425854
SATOSHI OGASAWARA ET AL.: "4T13a-14 Podoplanin ni Taisuru Gan Tokuiteki Kotai(CasMab) no Kaihatsu", ANNUAL MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY, vol. 87, 2 October 2014 (2014-10-02), pages 222, XP009506722
See also references of EP 3438130A4
TESTA JACQUELINE E. ET AL.: "Ubiquitous yet Distinct Expression of Podocalyxin on Vascular Surfaces in Normal and Tumor Tissues in the Rat", JOURNAL OF VASCULAR RESEARCH, vol. 46, 2009, pages 311 - 324, XP055548089
SCHOPPERLE W. MICHAEL ET AL.: "Human embryonal carcinoma tumor antigen, Gp200/GCTM-2, is podocalyxin", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 300, no. 2, January 2003 (2003-01-01), pages 285 - 290, XP002538479
BUGANIM YOSEF ET AL.: "Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression", CARCINOGENESIS, vol. 32, no. 12, 2011, pages 1749 - 1757, XP055425851
BARDERAS RODRIGO ET AL.: "In-depth Characterization of the Secretome of Colorectal Cancer Metastatic Cells Identifies Key Proteins in Cell Adhesion, Migration, and Invasion", MOLECULAR & CELLULAR PROTEOMICS, vol. 12, no. 6, June 2013 (2013-06-01), pages 1602 - 1620, XP055425854
SATOSHI OGASAWARA ET AL.: "4T13a-14 Podoplanin ni Taisuru Gan Tokuiteki Kotai(CasMab) no Kaihatsu", ANNUAL MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY, vol. 87, 2 October 2014 (2014-10-02), pages 222, XP009506722
See also references of EP 3438130A4
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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