Title:
ANTI-PODOPLANIN ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2018/179302
Kind Code:
A1
Abstract:
The present invention provides a cancer cell-specific anti-podoplanin antibody or an antigen-binding fragment thereof. The anti-podoplanin antibody is against the amino acid sequence of human podoplanin represented by SEQ ID NO: 1, the sequence having an epitope in a region including Thr85, the Thr85 having a sialic acid-containing O-type sugar chain attached thereto.
Inventors:
KATO YUKINARI (JP)
KATO MIKA (JP)
YAMADA SHINJI (JP)
OGASAWARA SATOSHI (JP)
NAKAMURA TAKURO (JP)
KATO MIKA (JP)
YAMADA SHINJI (JP)
OGASAWARA SATOSHI (JP)
NAKAMURA TAKURO (JP)
Application Number:
PCT/JP2017/013488
Publication Date:
October 04, 2018
Filing Date:
March 30, 2017
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
C07K16/36; A61K39/395; A61P35/00; C07K7/06; C07K14/745; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/08
Domestic Patent References:
| WO2015053381A1 | 2015-04-16 | |||
| WO2017010463A1 | 2017-01-19 | |||
| WO2015053381A1 | 2015-04-16 | |||
| WO2002031140A1 | 2002-04-18 |
Foreign References:
| JP2009225781A | 2009-10-08 |
Other References:
SEKIGUCHI, T. ET AL.: "Targeting a novel domain in podoplanin for inhibiting platelet-mediated tumor metastasis", ONCOTARGET, vol. 7, no. 4, 2016, pages 3934 - 3946, XP055345553
KANEKO, M. K. ET AL.: "Functional glycosylation of human podoplanin: Glycan structure of platelet aggregation-inducing factor", FEBS LETTERS, vol. 581, 2007, pages 331 - 336, XP055539795
KATO YOGASAWARA SOKI HGOICHBERG PHONMA RFUJII YKANEKO MK: "LpMab-12 Established by CasMab Technology Specifically Detects Sialylated O-glycan on Thr52 of Platelet Aggregation-stimulating Domain of Human Podoplanin", PLOS ONE, vol. 11, no. 3, 2016, pages e0152912
KATO YKUNITA AABE SOGASAWARA SFUJII YOKI HFUKAYAMA MNISHIOKA YKANEKO MK: "The chimeric antibody chLpMab-7 targeting human podoplanin suppresses pulmonary metastasis via ADCC and CDC rather than via its neutralizing activity", ONCOTARGET, 2015, pages 36003 - 36018
KATO YKANEKO MK: "A Cancer-specific Monoclonal Antibody Recognizes the Aberrantly Glycosylated Podoplanin", SCI REP., vol. 4, 2014, pages 5924
KANEKO MKYAMADA SNAKAMURA TABE SNISHIOKA YKUNITA AFUKAYAMA MFUJII YOGASAWARA SKATO Y: "Antitumor activity of chLpMab-2, a human-mouse chimeric cancer-specific antihuman podoplanin antibody, via antibody-dependent cellular cytotoxicity", CANCER MED.
WU ET AL., PNAS, vol. 95, 1998, pages 6037 - 6042
SCHIER, R. ET AL., J. MOL. BIO., vol. 263, 1996, pages 551 - 567
SCHIER, R. ET AL., J. MOL. BIOL., vol. 255, 1996, pages 28 - 43
YANG, W.P. ET AL., J. MOL. BIOL., vol. 254, 1995, pages 392 - 403
SEO, H. ET AL., NAT. BIOTECHNOL., vol. 6, 2002, pages 731 - 736
ITOH, K. ET AL., JPN. J. CANCER RES., vol. 92, 2001, pages 1313 - 1321
KOIDE, A. ET AL., J. MOL. BIOL., vol. 284, 1998, pages 1141 - 1151
See also references of EP 3674324A4
KANEKO, M. K. ET AL.: "Functional glycosylation of human podoplanin: Glycan structure of platelet aggregation-inducing factor", FEBS LETTERS, vol. 581, 2007, pages 331 - 336, XP055539795
KATO YOGASAWARA SOKI HGOICHBERG PHONMA RFUJII YKANEKO MK: "LpMab-12 Established by CasMab Technology Specifically Detects Sialylated O-glycan on Thr52 of Platelet Aggregation-stimulating Domain of Human Podoplanin", PLOS ONE, vol. 11, no. 3, 2016, pages e0152912
KATO YKUNITA AABE SOGASAWARA SFUJII YOKI HFUKAYAMA MNISHIOKA YKANEKO MK: "The chimeric antibody chLpMab-7 targeting human podoplanin suppresses pulmonary metastasis via ADCC and CDC rather than via its neutralizing activity", ONCOTARGET, 2015, pages 36003 - 36018
KATO YKANEKO MK: "A Cancer-specific Monoclonal Antibody Recognizes the Aberrantly Glycosylated Podoplanin", SCI REP., vol. 4, 2014, pages 5924
KANEKO MKYAMADA SNAKAMURA TABE SNISHIOKA YKUNITA AFUKAYAMA MFUJII YOGASAWARA SKATO Y: "Antitumor activity of chLpMab-2, a human-mouse chimeric cancer-specific antihuman podoplanin antibody, via antibody-dependent cellular cytotoxicity", CANCER MED.
WU ET AL., PNAS, vol. 95, 1998, pages 6037 - 6042
SCHIER, R. ET AL., J. MOL. BIO., vol. 263, 1996, pages 551 - 567
SCHIER, R. ET AL., J. MOL. BIOL., vol. 255, 1996, pages 28 - 43
YANG, W.P. ET AL., J. MOL. BIOL., vol. 254, 1995, pages 392 - 403
SEO, H. ET AL., NAT. BIOTECHNOL., vol. 6, 2002, pages 731 - 736
ITOH, K. ET AL., JPN. J. CANCER RES., vol. 92, 2001, pages 1313 - 1321
KOIDE, A. ET AL., J. MOL. BIOL., vol. 284, 1998, pages 1141 - 1151
See also references of EP 3674324A4
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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