Title:
ANTI-PVRIG ANTIBODIES AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2024/032700
Kind Code:
A1
Abstract:
Anti-PVRIG antibodies and antigen-binding fragments thereof, are provided, as are related compositions and methods. The antibodies bind to human PVRIG receptor and can block the interaction between the PVRL2 ligand on one cell with PVRIG on an immune cell.
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Inventors:
TANG XIAOYAN (CN)
LI DAN (CN)
QIAN MENGRAN (CN)
JI RUYUE (CN)
PAN JIE (CN)
CHEN XIN (CN)
JIANG LEI (CN)
DING XIAO (CN)
LI HUI (CN)
SONG JING (CN)
SUN JIAN (CN)
YI MEIQI (CN)
LI DAN (CN)
QIAN MENGRAN (CN)
JI RUYUE (CN)
PAN JIE (CN)
CHEN XIN (CN)
JIANG LEI (CN)
DING XIAO (CN)
LI HUI (CN)
SONG JING (CN)
SUN JIAN (CN)
YI MEIQI (CN)
Application Number:
PCT/CN2023/112161
Publication Date:
February 15, 2024
Filing Date:
August 10, 2023
Export Citation:
Assignee:
BEIGENE LTD (GB)
TANG XIAOYAN (CN)
TANG XIAOYAN (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; G01N33/574
Domestic Patent References:
| WO2016134333A1 | 2016-08-25 | |||
| WO2021021837A2 | 2021-02-04 | |||
| WO2021180205A1 | 2021-09-16 |
Foreign References:
| CN114644711A | 2022-06-21 | |||
| US20180169238A1 | 2018-06-21 |
Other References:
LI YANGYANG, ZHANG YU, CAO GUOSHUAI, ZHENG XIAODONG, SUN CHENG, WEI HAIMING, TIAN ZHIGANG, XIAO WEIHUA, SUN RUI, SUN HAOYU: "Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors", JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 14, no. 1, 1 December 2021 (2021-12-01), XP055914749, DOI: 10.1186/s13045-021-01112-3
WHELAN, S. ET AL: "PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function", CANCER IMMUNOLOGY RESEARCH, vol. 7, no. 2, 28 February 2019 (2019-02-28), XP055794523, DOI: 10.1158/2326-6066.CIR-18-0442
ALTEBER ZOYA, COJOCARU GADY, FRENKEL MASHA, WEYL EMMANUEL, SABATH NIV, WOOL ASSAF, NOVIK AMIT, KLIGER YOSSEF, LEVINE ZURIT, OPHIR : "252 Novel DNAM-1 axis member, PVRIG, is potentially a dominant checkpoint involved in stem-like memory T cells – dendritic cell interaction", JOURNAL FOR IMMUNOTHERAPY OF CANCER, BIOMED CENTRAL, LONDON, GB, vol. 9, no. Suppl 2, 1 November 2021 (2021-11-01), GB , pages A272 - A273, XP093137736, ISSN: 2051-1426, DOI: 10.1136/jitc-2021-SITC2021.252
SANCHEZ-CORREA, B. ET AL: "DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy", CANCERS, vol. 11, 23 June 2019 (2019-06-23), XP055846585, DOI: 10.3390/cancers11060877
WHELAN, S. ET AL: "PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function", CANCER IMMUNOLOGY RESEARCH, vol. 7, no. 2, 28 February 2019 (2019-02-28), XP055794523, DOI: 10.1158/2326-6066.CIR-18-0442
ALTEBER ZOYA, COJOCARU GADY, FRENKEL MASHA, WEYL EMMANUEL, SABATH NIV, WOOL ASSAF, NOVIK AMIT, KLIGER YOSSEF, LEVINE ZURIT, OPHIR : "252 Novel DNAM-1 axis member, PVRIG, is potentially a dominant checkpoint involved in stem-like memory T cells – dendritic cell interaction", JOURNAL FOR IMMUNOTHERAPY OF CANCER, BIOMED CENTRAL, LONDON, GB, vol. 9, no. Suppl 2, 1 November 2021 (2021-11-01), GB , pages A272 - A273, XP093137736, ISSN: 2051-1426, DOI: 10.1136/jitc-2021-SITC2021.252
SANCHEZ-CORREA, B. ET AL: "DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy", CANCERS, vol. 11, 23 June 2019 (2019-06-23), XP055846585, DOI: 10.3390/cancers11060877
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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