ANTI-RAMP2 ANTIBODY - GENE TECHNO SCIENCE CO LTD

Title:

ANTI-RAMP2 ANTIBODY

Document Type and Number:

WIPO Patent Application WO/2019/054460

Kind Code:

A1

Abstract:

With regard to an anti-RAMP2 antibody having a cAMP inhibitory effect and an HUVEC antiproliferative effect, the present invention provides an angiogenesis inhibitor containing said antibody as an active ingredient. Specifically, the present invention relates to, in an in vitro proliferation test: an antibody against a receptor activity modifying protein2 (RAMP2) having an antiproliferative effect of vascular endothelial cells, or immunoreactive fragments thereof; or an antibody having an effect of inhibiting cAMP production caused by animal cells through the addition of adrenomedullin, or immunoreactive fragments thereof.

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Inventors:

SHINDO TAKAYUKI (JP)
NAKAMURA TETSURO (JP)
MAEDA RYU (JP)
NAKAYAMA YOSUKE (JP)

Application Number:

PCT/JP2018/034076

Publication Date:

March 21, 2019

Filing Date:

September 13, 2018

Export Citation:

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Assignee:

GENE TECHNO SCIENCE CO LTD (JP)

International Classes:

C07K16/18; A61K39/395; A61P3/10; A61P9/00; A61P9/10; A61P17/00; A61P19/02; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P35/04; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12P21/08

Domestic Patent References:

WO2004050834A2	2004-06-17
WO2009069546A1	2009-06-04

Foreign References:

JP2009504681A	2009-02-05
JP2012246309A	2012-12-13

Attorney, Agent or Firm:

NAKATANI Tomoko (JP)

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