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Title:
ANTI-ROR1 ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2016/187220
Kind Code:
A3
Abstract:
The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.

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Inventors:
WONG BRIAN (US)
MASTELLER EMMA (US)
LIU CHENG (US)
XU YIYANG (US)
LIU HONG (US)
YAN SU (US)
XIANG JINGYI (US)
WANG PEI (US)
Application Number:
PCT/US2016/032911
Publication Date:
December 15, 2016
Filing Date:
May 17, 2016
Export Citation:
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Assignee:
FIVE PRIME THERAPEUTICS INC (US)
EUREKA THERAPEUTICS INC (US)
International Classes:
A61K39/395; C07K16/28; C12N1/15; C12N1/21; G01N33/574
Domestic Patent References:
WO2013079973A12013-06-06
WO2014105849A12014-07-03
Foreign References:
US20130251723A12013-09-26
US20120282177A12012-11-08
US20100062005A12010-03-11
US20040110930A12004-06-10
US20090232804A12009-09-17
US20030232009A12003-12-18
Other References:
ZHANG, S ET AL.: "ROR1 Is Expressed in Human Breast Cancer and Associated with Enhanced Tumor- Cell Growth", PLOS ONE, vol. 7, no. 3, 2012, pages e31127, XP055333328
Attorney, Agent or Firm:
MASHRUWALA, Mary Anne et al. (1299 Pennsylvania Avenue NW, Suite 70, Washington District of Columbia, US)
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