Title:
ANTI-SENESCENCE COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/118014
Kind Code:
A3
Abstract:
The invention relates to a peptide comprising the amino acid sequence LTLRKEPASEIAQSILEAYSQNGWANRRSGGKRP, wherein the amino acids in said amino acid sequence are D-amino acid residues, and to methods for the use of this peptide in the treatment of age-related disorders
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Inventors:
DE KEIZER PETERUS LEONARDUS JOSEPHUS (NL)
Application Number:
PCT/NL2016/050057
Publication Date:
November 17, 2016
Filing Date:
January 25, 2016
Export Citation:
Assignee:
UNIV ERASMUS MED CT ROTTERDAM (NL)
International Classes:
A61K38/08; A61K38/10; A61K38/17; A61P25/28; A61P31/00; C07K14/47
Domestic Patent References:
| WO2013152041A1 | 2013-10-10 | |||
| WO2013152038A1 | 2013-10-10 |
Foreign References:
| US20060276459A1 | 2006-12-07 |
Other References:
R. LUPERTZ ET AL: "The forkhead transcription factor FOXO4 sensitizes cancer cells to doxorubicin-mediated cytotoxicity", CARCINOGENESIS, vol. 29, no. 11, 6 August 2008 (2008-08-06), pages 2045 - 2052, XP055188241, ISSN: 0143-3334, DOI: 10.1093/carcin/bgn184
K. C. FOY ET AL: "Combination Treatment with HER-2 and VEGF Peptide Mimics Induces Potent Anti-tumor and Anti-angiogenic Responses in Vitro and in Vivo", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 15, 15 April 2011 (2011-04-15), pages 13626 - 13637, XP055185618, ISSN: 0021-9258, DOI: 10.1074/jbc.M110.216820
JINGHUI ZHANG ET AL: "A novel retinoblastoma therapy from genomic and epigenetic analyses", NATURE, 11 January 2012 (2012-01-11), XP055188222, ISSN: 0028-0836, DOI: 10.1038/nature10733
K. C. FOY ET AL: "Combination Treatment with HER-2 and VEGF Peptide Mimics Induces Potent Anti-tumor and Anti-angiogenic Responses in Vitro and in Vivo", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 15, 15 April 2011 (2011-04-15), pages 13626 - 13637, XP055185618, ISSN: 0021-9258, DOI: 10.1074/jbc.M110.216820
JINGHUI ZHANG ET AL: "A novel retinoblastoma therapy from genomic and epigenetic analyses", NATURE, 11 January 2012 (2012-01-11), XP055188222, ISSN: 0028-0836, DOI: 10.1038/nature10733
Attorney, Agent or Firm:
JANSEN C.M. (Carnegieplein 5, 2517 KJ Den Haag, NL)
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