Title:
ANTI-SIGLEC15 ANTIBODY WITH MODIFIED CDR
Document Type and Number:
WIPO Patent Application WO/2013/147213
Kind Code:
A1
Abstract:
To provide an abnormal-bone-metabolism treatment and/or a prophylactic pharmaceutical composition targeting a protein coded for by a gene that is strongly expressed in osteoclasts. The provision, etc., of a pharmaceutical composition containing an antibody that specifically recognizes human SIGLEC15 and exhibits the effect of inhibiting the formation of osteoclasts.
Inventors:
HIRUMA YOSHIHARU (JP)
KIMURA TAKAKO (JP)
SHIMIZU HIRONARI (JP)
KIMURA TAKAKO (JP)
SHIMIZU HIRONARI (JP)
Application Number:
PCT/JP2013/059654
Publication Date:
October 03, 2013
Filing Date:
March 29, 2013
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C12N15/09; A61K39/395; A61P1/02; A61P7/00; A61P19/00; A61P19/02; A61P19/10; A61P29/00; A61P35/00; A61P43/00; C07K16/18; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Domestic Patent References:
| WO2010117011A1 | 2010-10-14 | |||
| WO2009048072A1 | 2009-04-16 | |||
| WO2007093042A1 | 2007-08-23 | |||
| WO2009048072A1 | 2009-04-16 | |||
| WO2010117011A1 | 2010-10-14 | |||
| WO2011041894A1 | 2011-04-14 | |||
| WO2010117011A1 | 2010-10-14 | |||
| WO1990007861A1 | 1990-07-26 | |||
| WO1999054342A1 | 1999-10-28 | |||
| WO2000061739A1 | 2000-10-19 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2004061104A2 | 2004-07-22 |
Foreign References:
| US4946778A | 1990-08-07 | |||
| US5260203A | 1993-11-09 | |||
| US5091513A | 1992-02-25 | |||
| US5455030A | 1995-10-03 |
Other References:
ENDOCRINOLOGICAL REVIEW, vol. 13, 1992, pages 66 - 80
"Principles of Bone Biology", 1996, ACADEMIC PRESS, pages: 87 - 102
ENDOCRINOLOGICAL REVIEW, vol. 17, 1996, pages 308 - 332
AMERICAN JOURNAL OF PHYSIOLOGY, vol. 260, 1991, pages C1315 - C1324
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE OF THE UNITED STATES OF AMERICA, vol. 95, 1998, pages 3597 - 3602
CELL, vol. 93, 1998, pages 165 - 176
JOURNAL OF BONE AND MINERAL RESEARCH, vol. 23, 1998, pages S222
NATURE, vol. 397, 1999, pages 315 - 323
NATURE REVIEWS IMMUNOLOGY, vol. 7, 2007, pages 255 - 266
GLYCOBIOLOGY, vol. 17, 2007, pages 838 - 846
SAIKI, R. K. ET AL., SCIENCE, vol. 239, 1988, pages 487 - 49
BULLOUGH ET AL.: "Atlas of Orthopedic Pathology", 1992, LIPPINCOTT WILLIAMS & WILKINS PUBLISHERS, pages: 17.6 - 17.8
YOUNG-YUN KONG, NATURE, vol. 397, 1999, pages 315 - 323
KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
"Monoclonal Antibodies", 1980, PLENUM PRESS, pages: 365 - 367
NATURE, vol. 321, 1986, pages 522 - 525
"SEQUENCES OF PROTEINS OF IMMUNOLOGICAL INTEREST", 1991
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
ANALYTICAL BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
LORI BURTON, PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, vol. 12, 2007, pages 265 - 273
LEE, H-S, MOLECULAR IMMUNOLOGY, vol. 36, 1999, pages 61 - 71
SHIRRMANN, T., MABS, vol. 2, no. 1, 2010, pages 1 - 4
MUYLDEMANS S., PROTEIN ENG., vol. 7, no. 9, 1994, pages 1129 - 35
HAMERS-CASTERMAN C., NATURE, vol. 363, no. 6428, 1993, pages 446 - 8
URLAUB, G.; CHASIN, L. A., PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4126 - 4220
GLUZMAN, Y., CELL, vol. 23, 1981, pages 175 - 182
MILLSTEIN ET AL., NATURE, vol. 305, 1983, pages 537 - 539
PLUCKTHUN: "The Pharmacology of Monoclonal Antibodies", vol. 113, 1994, SPRINGER VERLAG, pages: 269 - 315
NATURE BIOTECHNOLOGY, vol. 23, 2005, pages 1126 - 1136
HUSTON, J. S. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
NATURE BIOTECHNOLOGY, vol. 23, 2005, pages 1137 - 1146
"Strategies for Protein Purification and Characterization: A Laboratory Course Manual", 1996, COLD SPRING HARBOR LABORATORY PRESS
ED HARLOW; DAVID LANE: "Antibodies: A Laboratory Manual.", 1988, COLD SPRING HARBOR LABORATORY
"Normal Human Natural Osteoclast Precursor Cells", SANKO JUNYAKU CO., LTD.
TAKADA ET AL., BONE AND MINERAL, vol. 17, 1992, pages 347 - 359
ROMAS E. ET AL., BONE, vol. 30, 2002, pages 340 - 346
M. C. GARNET: "Targeted drug conjugates: principles and progress", ADVANCED DRUG DELIVERY REVIEWS, vol. 53, 2001, pages 171 - 216, XP002261805, DOI: doi:10.1016/S0169-409X(01)00227-7
G. T. HERMANSON: "Bioconjugate Techniques", 1996, ACADEMIC PRESS
PUTNAM; J. KOPECEK: "Polymer Conjugates with Anticancer Activity", ADVANCES IN POLYMER SCIENCE, vol. 122, 1995, pages 55 - 123, XP009041750
D. D. LASIC: "Liposomes: From Physics to Applications", 1993, ELSEVIER SCIENCE PUBLISHERS B. V.
D. PUTNAM; J. KOPECEK: "Polymer Conjugates with Anticancer Activity", ADVANCES IN POLYMER SCIENCE, vol. 122, 1995, pages 55 - 123
SAMBROOK, J.; FRITSCH, E. F.; MANIATIS, T.: "Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 2832857A4
"Principles of Bone Biology", 1996, ACADEMIC PRESS, pages: 87 - 102
ENDOCRINOLOGICAL REVIEW, vol. 17, 1996, pages 308 - 332
AMERICAN JOURNAL OF PHYSIOLOGY, vol. 260, 1991, pages C1315 - C1324
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE OF THE UNITED STATES OF AMERICA, vol. 95, 1998, pages 3597 - 3602
CELL, vol. 93, 1998, pages 165 - 176
JOURNAL OF BONE AND MINERAL RESEARCH, vol. 23, 1998, pages S222
NATURE, vol. 397, 1999, pages 315 - 323
NATURE REVIEWS IMMUNOLOGY, vol. 7, 2007, pages 255 - 266
GLYCOBIOLOGY, vol. 17, 2007, pages 838 - 846
SAIKI, R. K. ET AL., SCIENCE, vol. 239, 1988, pages 487 - 49
BULLOUGH ET AL.: "Atlas of Orthopedic Pathology", 1992, LIPPINCOTT WILLIAMS & WILKINS PUBLISHERS, pages: 17.6 - 17.8
YOUNG-YUN KONG, NATURE, vol. 397, 1999, pages 315 - 323
KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
"Monoclonal Antibodies", 1980, PLENUM PRESS, pages: 365 - 367
NATURE, vol. 321, 1986, pages 522 - 525
"SEQUENCES OF PROTEINS OF IMMUNOLOGICAL INTEREST", 1991
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
ANALYTICAL BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
LORI BURTON, PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, vol. 12, 2007, pages 265 - 273
LEE, H-S, MOLECULAR IMMUNOLOGY, vol. 36, 1999, pages 61 - 71
SHIRRMANN, T., MABS, vol. 2, no. 1, 2010, pages 1 - 4
MUYLDEMANS S., PROTEIN ENG., vol. 7, no. 9, 1994, pages 1129 - 35
HAMERS-CASTERMAN C., NATURE, vol. 363, no. 6428, 1993, pages 446 - 8
URLAUB, G.; CHASIN, L. A., PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4126 - 4220
GLUZMAN, Y., CELL, vol. 23, 1981, pages 175 - 182
MILLSTEIN ET AL., NATURE, vol. 305, 1983, pages 537 - 539
PLUCKTHUN: "The Pharmacology of Monoclonal Antibodies", vol. 113, 1994, SPRINGER VERLAG, pages: 269 - 315
NATURE BIOTECHNOLOGY, vol. 23, 2005, pages 1126 - 1136
HUSTON, J. S. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
NATURE BIOTECHNOLOGY, vol. 23, 2005, pages 1137 - 1146
"Strategies for Protein Purification and Characterization: A Laboratory Course Manual", 1996, COLD SPRING HARBOR LABORATORY PRESS
ED HARLOW; DAVID LANE: "Antibodies: A Laboratory Manual.", 1988, COLD SPRING HARBOR LABORATORY
"Normal Human Natural Osteoclast Precursor Cells", SANKO JUNYAKU CO., LTD.
TAKADA ET AL., BONE AND MINERAL, vol. 17, 1992, pages 347 - 359
ROMAS E. ET AL., BONE, vol. 30, 2002, pages 340 - 346
M. C. GARNET: "Targeted drug conjugates: principles and progress", ADVANCED DRUG DELIVERY REVIEWS, vol. 53, 2001, pages 171 - 216, XP002261805, DOI: doi:10.1016/S0169-409X(01)00227-7
G. T. HERMANSON: "Bioconjugate Techniques", 1996, ACADEMIC PRESS
PUTNAM; J. KOPECEK: "Polymer Conjugates with Anticancer Activity", ADVANCES IN POLYMER SCIENCE, vol. 122, 1995, pages 55 - 123, XP009041750
D. D. LASIC: "Liposomes: From Physics to Applications", 1993, ELSEVIER SCIENCE PUBLISHERS B. V.
D. PUTNAM; J. KOPECEK: "Polymer Conjugates with Anticancer Activity", ADVANCES IN POLYMER SCIENCE, vol. 122, 1995, pages 55 - 123
SAMBROOK, J.; FRITSCH, E. F.; MANIATIS, T.: "Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 2832857A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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