Title:
ANTI-TNF-Α/CXCL10 DOUBLE-TARGETING ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/189306
Kind Code:
A1
Abstract:
The present invention relates to a TNF-α (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable region and a light chain variable region of the CXCL10 specific antibody binds to the C-terminus of the heavy chain variable region of the TNF-α specific antibody, is a bispecific antibody that effectively binds to both TNF-α and CXCL10, and thus the antibody can be useful as a double targeting antibody capable of identifying TNF-α/CXCL10. A composition of the present invention comprises a TNF-α/CXCL-10 double targeting antibody which effectively binds to both TNF-α and CXCL10. The double targeting antibody of the present invention has excellent TNF-α inhibitory activity and osteoclast differentiation inhibitory activity compared with the TNF-α or CXCL10 single targeting antibody. The composition of the present invention can be used in preventing or treating immunological disease.
Inventors:
KANG HEUN-SOO (KR)
PARK SO-HYUN (KR)
SONG YEONG WOOK (KR)
SHIN KI CHUL (KR)
LEE EUN YOUNG (KR)
LEE EUN BONG (KR)
PARK YOUNG WOO (KR)
PARK BUM-CHAN (KR)
LEE DONG HEE (KR)
KIM DONG JIN (KR)
YUN SEON HA (KR)
LEE KE SE (KR)
LEE HYUN JU (KR)
KIM KYUNG JIN (KR)
KIM HEE CHAN (KR)
YOO SEOK HO (KR)
JANG MYEOUNG HEE (KR)
JANG SEIL (KR)
PARK SO-HYUN (KR)
SONG YEONG WOOK (KR)
SHIN KI CHUL (KR)
LEE EUN YOUNG (KR)
LEE EUN BONG (KR)
PARK YOUNG WOO (KR)
PARK BUM-CHAN (KR)
LEE DONG HEE (KR)
KIM DONG JIN (KR)
YUN SEON HA (KR)
LEE KE SE (KR)
LEE HYUN JU (KR)
KIM KYUNG JIN (KR)
KIM HEE CHAN (KR)
YOO SEOK HO (KR)
JANG MYEOUNG HEE (KR)
JANG SEIL (KR)
Application Number:
PCT/KR2014/004579
Publication Date:
November 27, 2014
Filing Date:
May 22, 2014
Export Citation:
Assignee:
METABOLIC ENGINEERING LAB CO LTD (KR)
SNU R&DB FOUNDATION (KR)
KOREA RES INST OF BIOSCIENCE (KR)
SNU R&DB FOUNDATION (KR)
KOREA RES INST OF BIOSCIENCE (KR)
International Classes:
C07K16/46; A61K39/395
Domestic Patent References:
| WO2013055958A1 | 2013-04-18 |
Foreign References:
| US8258268B2 | 2012-09-04 | |||
| KR20100097720A | 2010-09-03 | |||
| KR20120125611A | 2012-11-16 | |||
| US20050053600A1 | 2005-03-10 |
Other References:
BECK A, NAT REV IMMUNOLOGY, vol. 10, 2010, pages 345 - 352
BOSTROM, J, SCIENCE, vol. 323, 2009, pages 1610 - 1614
GENNARO: "Remington's Pharmaceutical Sciences 19th ed.,", 1995
ARNON ET AL., RECENT RESULTS IN CANCER RES., vol. 75, 1980, pages 236
MOOLTON ET AL., IMMUNOLOG. RES., vol. 62, 1982, pages 47
See also references of EP 3000827A4
BOSTROM, J, SCIENCE, vol. 323, 2009, pages 1610 - 1614
GENNARO: "Remington's Pharmaceutical Sciences 19th ed.,", 1995
ARNON ET AL., RECENT RESULTS IN CANCER RES., vol. 75, 1980, pages 236
MOOLTON ET AL., IMMUNOLOG. RES., vol. 62, 1982, pages 47
See also references of EP 3000827A4
Attorney, Agent or Firm:
YANG, Boo-Hyun (Chundong Building1992, Namboosunhwan-r, Gwanak-gu Seoul 151-832, KR)
Download PDF:
Previous Patent: PORTABLE PNEUMATIC HEART MACHINE WITH AIR COMPRESSOR
Next Patent: WIRELESS POWER TRANSMISSION APPARATUS AND METHOD
Next Patent: WIRELESS POWER TRANSMISSION APPARATUS AND METHOD