Title:
AN ANTI-TUMOR RNA INTERFERENCE DRUG FOR MULTIDRUG RESISTANCE
Document Type and Number:
WIPO Patent Application WO/2005/002594
Kind Code:
A1
Abstract:
The invention discloses a kind of anti-tumor RNA interference drug for multidrug resistance, and provides a group of polynucleotide sequences of RNAi used as medicament against leukemia and other tumors in which the expression of multidrug resistance gene (mdr-1) and the functionality of P-glycoprotein (P-gp) are involved. The drug aims to inhibit the expression of multidrug resistance gene (mdr-1) and the functionality of P-glycoprotein (P-gp) in tumor cells, increases the sensitivity of leukemia to the normal chemotherapy medicament, and enhances the effect that the chemotherapy medicament kills cells of malignancy in the hemopoietic system.
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Inventors:
HAN ZHONGCHAO (CN)
PENG ZHI (CN)
PENG ZHI (CN)
Application Number:
PCT/CN2004/000762
Publication Date:
January 13, 2005
Filing Date:
July 07, 2004
Export Citation:
Assignee:
INST OF HEMATOLOGY CHINESE ACA (CN)
HAN ZHONGCHAO (CN)
PENG ZHI (CN)
HAN ZHONGCHAO (CN)
PENG ZHI (CN)
International Classes:
A61P35/00; C12N15/113; (IPC1-7): A61K31/713; A61P35/00; C12N15/11
Domestic Patent References:
| WO2003035082A1 | 2003-05-01 |
Other References:
PENG Z. ET AL.: "Reversal of multi-drug resistance in K562/A02 cells by small interference RNA of mdr1 gene", CHIN. J. HEMATOL., vol. 25, no. 1, January 2004 (2004-01-01), pages 5 - 7
REID G. ET AL.: "The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs", PROC. NATL. ACAD. SCI. USA, vol. 100, no. 16, August 2003 (2003-08-01), pages 9244 - 9249
NIETH C. ET AL.: "Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi)", FEBS LETTERS, vol. 545, 16 May 2003 (2003-05-16), pages 144 - 150
WU H. ET AL.: "Small interfering RNA-induced suppression of MDR1 (P-glycoprotein)restores sensitivity to multidrug-resistant cancer cells", CANCER RESEARCH, vol. 63, 1 April 2003 (2003-04-01), pages 1515 - 1519
REID G. ET AL.: "The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs", PROC. NATL. ACAD. SCI. USA, vol. 100, no. 16, August 2003 (2003-08-01), pages 9244 - 9249
NIETH C. ET AL.: "Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi)", FEBS LETTERS, vol. 545, 16 May 2003 (2003-05-16), pages 144 - 150
WU H. ET AL.: "Small interfering RNA-induced suppression of MDR1 (P-glycoprotein)restores sensitivity to multidrug-resistant cancer cells", CANCER RESEARCH, vol. 63, 1 April 2003 (2003-04-01), pages 1515 - 1519
Attorney, Agent or Firm:
TIANJIN CAIZHI PETENT & TRADEMARK AGENCY, LTD (No. 149 Weijin Road Heping District, Tianjin 0, CN)
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