Title:
ANTI-TUMOUR AGENT, MARKER FOR TUMOUR DETECTION, AND ORAL VACCINE AGENT
Document Type and Number:
WIPO Patent Application WO/2014/010758
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an anti-tumour agent and/or marker for tumour detection which have low invasiveness, few side effects, and high target specificity. Provided are a marker for tumour detection, which enables treatment effects to be monitored over time, and/or an anti-tumour agent, which can deliver functional peptides to target cells, the marker and the anti-tumour agent having said properties as a result of using a recombinant strict anaerobe gram-positive bacterium as an active ingredient, said bacterium containing a nucleic acid which codes a secretory fused protein comprising a signal peptide, a low molecular weight single-chain antibody, and a functional peptide.
Inventors:
TAIRA YUICHIRO (JP)
ISHIDA ISAO (JP)
ISHIDA ISAO (JP)
Application Number:
PCT/JP2013/069717
Publication Date:
January 16, 2014
Filing Date:
July 12, 2013
Export Citation:
Assignee:
TEIKYO HEISEI UNIVERSITY (JP)
International Classes:
C12N1/21; A61K35/74; A61K39/02; A61K48/00; A61P35/00; C12N15/09; C12Q1/04; A61K39/00; C07K16/00; C07K19/00
Domestic Patent References:
| WO2010126073A1 | 2010-11-04 | |||
| WO2011005756A1 | 2011-01-13 | |||
| WO2010126073A1 | 2010-11-04 |
Foreign References:
| GB2482535A | 2012-02-08 | |||
| JP2005523875A | 2005-08-11 | |||
| JP3642755B2 | 2005-04-27 | |||
| JP2009541319A | 2009-11-26 | |||
| JP2012158044A | 2012-08-23 | |||
| JP2008534933A | 2008-08-28 | |||
| JP2009511032A | 2009-03-19 |
Other References:
TANIGUCHI S. ET AL.: "Targeting solid tumors with non-pathogenic obligate anaerobic bacteria", CANCER SCI., vol. 101, no. 9, 2010, pages 1925 - 1932, XP055184119
KIMURA N.T. ET AL., CANCER RES., vol. 40, no. 6, 1980, pages 2061 - 2068
TREDAN O ET AL., J NATL CANCER INST, vol. 99, 2007, pages 1441 - 1454
S. TANIGUCHI ET AL., CANCER. SCI., vol. 101, no. 9, 2010, pages 1925
DANG L.H. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 98, 2001, pages 15155 - 15160
IAN C. ET AL., SCIENCE, vol. 314, 2006, pages 1308 - 1311
PAWELEK J.M. ET AL., CANCER RES., vol. 57, 1997, pages 4537 - 4544
TOSO J.F. ET AL., J. CLIN. ONCOL., vol. 20, 2002, pages 142 - 152
ZHANG L. ET AL., NATURE, vol. 362, 1993, pages 446 - 448
DEFFAR, K. ET AL., AFRICAN JOURNAL OF BIOTECHNOLOGY, vol. 8, no. 12, 2009, pages 2645 - 2652
"Pierce Catalog and Handbook", 1994, PIERCE CHEMICAL CO.
BRINKMANN U.; PASTAN I., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1198, no. 1, 1994, pages 27 - 45
SAMBROOK ET AL.: "Molecular Cloning", 2001, COLD SPRING HARBOR LABORATORY PRESS, article "Current Protocols in Molecular Biology"
AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS, article "A compendium of Methods from Current Protocols in Molecular Biology"
"Remington's Pharmaceutical Sciences", MERCK PUBLISHING CO.
KATZ, M.H. ET AL., CANCER RES., vol. 63, 2003, pages 5521 - 5525
SCHMITT, C.A. ET AL., CANCER CELL, vol. 1, 2002, pages 289 - 298
KATZ, M.H. ET AL., J. SURG. RES., vol. 113, 2003, pages 151 - 160
BRINKMANN U. ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1198, 1994, pages 27 - 45
ZHANG G. ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 227, no. 3, 1996, pages 707 - 11
SCHMIDT T.G.; SKERRA A., NAT PROTOC., vol. 2, no. 6, 2007, pages 1528 - 35
FOLIA PHARMACOL. JPN., vol. 137, 2011, pages 31 - 41
MCCLINTOCK J.L.; CERESA B.P., INVEST OPHTHALMOL VIS SCI., vol. 51, no. 7, 2010, pages 3455 - 3461
ANALYTICAL BIOCHEMISTRY, vol. 349, no. 1, 1 February 2006 (2006-02-01), pages 136 - 147
YASUI K ET AL., NUCLEIC ACIDS RES., vol. 37, no. 1, 2009, pages E3
TANAKA K ET AL., BIOSCI BIOTECHNOL BIOCHEM., vol. 69, no. 2, 2005, pages 422 - 425
YAZAWA K ET AL., CANCER GENE THERAPY, vol. 7, 2000, pages 269 - 274
JAMES G. ET AL., CLIN CANCER RES, vol. 7, 2001, pages 4230 - 4238
CLIN CANCER RES., vol. 14, 2008, pages 5142 - 5149
JAMES A. POSEY; MOHAMMAD B. KHAZAELI; MICHAEL A. BOOKMAN ET AL., CLIN CANCER RES, vol. 8, 2002, pages 3092 - 3099
See also references of EP 2873726A4
KIMURA N.T. ET AL., CANCER RES., vol. 40, no. 6, 1980, pages 2061 - 2068
TREDAN O ET AL., J NATL CANCER INST, vol. 99, 2007, pages 1441 - 1454
S. TANIGUCHI ET AL., CANCER. SCI., vol. 101, no. 9, 2010, pages 1925
DANG L.H. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 98, 2001, pages 15155 - 15160
IAN C. ET AL., SCIENCE, vol. 314, 2006, pages 1308 - 1311
PAWELEK J.M. ET AL., CANCER RES., vol. 57, 1997, pages 4537 - 4544
TOSO J.F. ET AL., J. CLIN. ONCOL., vol. 20, 2002, pages 142 - 152
ZHANG L. ET AL., NATURE, vol. 362, 1993, pages 446 - 448
DEFFAR, K. ET AL., AFRICAN JOURNAL OF BIOTECHNOLOGY, vol. 8, no. 12, 2009, pages 2645 - 2652
"Pierce Catalog and Handbook", 1994, PIERCE CHEMICAL CO.
BRINKMANN U.; PASTAN I., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1198, no. 1, 1994, pages 27 - 45
SAMBROOK ET AL.: "Molecular Cloning", 2001, COLD SPRING HARBOR LABORATORY PRESS, article "Current Protocols in Molecular Biology"
AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS, article "A compendium of Methods from Current Protocols in Molecular Biology"
"Remington's Pharmaceutical Sciences", MERCK PUBLISHING CO.
KATZ, M.H. ET AL., CANCER RES., vol. 63, 2003, pages 5521 - 5525
SCHMITT, C.A. ET AL., CANCER CELL, vol. 1, 2002, pages 289 - 298
KATZ, M.H. ET AL., J. SURG. RES., vol. 113, 2003, pages 151 - 160
BRINKMANN U. ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1198, 1994, pages 27 - 45
ZHANG G. ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 227, no. 3, 1996, pages 707 - 11
SCHMIDT T.G.; SKERRA A., NAT PROTOC., vol. 2, no. 6, 2007, pages 1528 - 35
FOLIA PHARMACOL. JPN., vol. 137, 2011, pages 31 - 41
MCCLINTOCK J.L.; CERESA B.P., INVEST OPHTHALMOL VIS SCI., vol. 51, no. 7, 2010, pages 3455 - 3461
ANALYTICAL BIOCHEMISTRY, vol. 349, no. 1, 1 February 2006 (2006-02-01), pages 136 - 147
YASUI K ET AL., NUCLEIC ACIDS RES., vol. 37, no. 1, 2009, pages E3
TANAKA K ET AL., BIOSCI BIOTECHNOL BIOCHEM., vol. 69, no. 2, 2005, pages 422 - 425
YAZAWA K ET AL., CANCER GENE THERAPY, vol. 7, 2000, pages 269 - 274
JAMES G. ET AL., CLIN CANCER RES, vol. 7, 2001, pages 4230 - 4238
CLIN CANCER RES., vol. 14, 2008, pages 5142 - 5149
JAMES A. POSEY; MOHAMMAD B. KHAZAELI; MICHAEL A. BOOKMAN ET AL., CLIN CANCER RES, vol. 8, 2002, pages 3092 - 3099
See also references of EP 2873726A4
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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