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Title:
ANTI-TUMOUR PLATINUM (II) COMPLEXES WITH CAMPHORIC RADICALS AS LIGANDS
Document Type and Number:
WIPO Patent Application WO/2004/110973
Kind Code:
A1
Abstract:
The present invention discloses platinum (II) complexes with effective anticancer activity, characterized in that the new platinum (II) complexes are formed by reacting the anionic ligand of Camphoric radicals with the cationic ligand of amine platinum. The preparation process of these complexes and the in vitro inhibition effect of leukemic cell, oophoroma cell, hepatoma cell and pulmonary carcinoma cell with the typical compounds of the present invention are also disclosed. The structures of the present complexes are represented by the following formulas: (1), (2) and (3), wherein the Camphoric radicals in formula (l), (2) and (3) can be DL type raceme, D type optical isomer [1R, 3S) - (+) -Camphoric radical] or L type optical isomer [(1S, 3R)-(-)-Camphoric radical]. In formula (1) R is the same, representing hydrogen atom, C1-5alkyl or Cl-8oxaalkyl; In formula (2) the cyclohexanediamine is 1,2-t­rans-cyclohexanediamine, wherein both of the two chiral carbon atoms (marked with *) have the absolute configuration of R or S; In formula (3) R1 and R2 linked to the 4, 5-bis (aminomethyl) -2-alkyl-1, 3-­dioxolane, same or different, independently represent hydrogen atoms or C1-5 alkyl, or link to one carbon to form a cycle, wherein both of the two chiral carbon atoms(marked with *) have the absolute configuration of R or S. The platinum complexes of the present invention include all stereomers and mixtures of compounds represented by above formulas.

Inventors:
Gou, Shaohua (No. 22 Hangkou Road, Nanjing, Jiangsu 3, 21009, CN)
Wang, Lianhong (No. 22 Hangkou Road, Nanjing, Jiangsu 3, 21009, CN)
Application Number:
PCT/CN2004/000585
Publication Date:
December 23, 2004
Filing Date:
June 02, 2004
Export Citation:
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Assignee:
NANJING UNIVERSITY (No. 22 Hangkou Road, Nanjing, Jiangsu 3, 21009, CN)
Gou, Shaohua (No. 22 Hangkou Road, Nanjing, Jiangsu 3, 21009, CN)
Wang, Lianhong (No. 22 Hangkou Road, Nanjing, Jiangsu 3, 21009, CN)
International Classes:
C07C61/06; C07C211/65; C07D317/28; (IPC1-7): C07C51/41; C07C59/29; C07C209/66; C07C211/02; C07C211/08; C07C211/18; C07D317/10; C07D317/72
Other References:
WANG, LONGGUI ET AL: 'Effect of camphoramine chloroacetic platinum on biomacromolecules in L1210 leukemia cell' YAOXUE XUEBAO vol. 22, no. 2, 1987, pages 87 - 92
TANG, WENXIA ET AL.: 'Platinum complexes with low toxicity and high activity' ZIRAN ZAZHI vol. 8, no. 10, 1985, pages 764 - 765
Attorney, Agent or Firm:
NANJING JINGWEI PATENT & TRADEMARK AGENCY CO., LTD. (No. 6 Yangtse River Rear Street, Nanjing, Jiangsu 8, 21001, CN)
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