Title:
ANTIBACTERIAL AGENT FOR DRUG-RESISTANT BACTERIA, METHOD FOR SCREENING FOR SAME, AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2011/058923
Kind Code:
A1
Abstract:
An antibacterial agent for drug-resistant bacteria, which comprises either nibomycin and/or a derivative thereof and is effective on drug-resistant bacteria each having resistance to at least one drug.
Inventors:
IGARASHI MASAYUKI (JP)
HIRAMATSU KEIICHI (JP)
HIRAMATSU KEIICHI (JP)
Application Number:
PCT/JP2010/069674
Publication Date:
May 19, 2011
Filing Date:
November 05, 2010
Export Citation:
Assignee:
MICROBIAL CHEM RES FOUND (JP)
JUNTENDO EDUCATIONAL FOUNDATION (JP)
IGARASHI MASAYUKI (JP)
HIRAMATSU KEIICHI (JP)
JUNTENDO EDUCATIONAL FOUNDATION (JP)
IGARASHI MASAYUKI (JP)
HIRAMATSU KEIICHI (JP)
International Classes:
A61K31/4745; A61K31/4375; A61K31/4709; A61K31/496; A61K31/5383; A61P31/04; A61P43/00; C07D498/16
Foreign References:
| JPH11506101A | 1999-06-02 | |||
| JP2007126452A | 2007-05-24 | |||
| JP2004532876A | 2004-10-28 |
Other References:
MASAYOSHI ARAI ET AL.: "Kosei Busshitsu nybomycin no Senzaisei Kekkakukin ni Taisuru Kokin Kassei to sono Sayo Mechanism no Kaiseki", DAI 27 KAI ABSTRACTS OF SYMPOSIUM ON MEDICINAL CHEMISTRY, 2008, pages 354 - 355, XP008160344
STRELITZ,F. ET AL.: "Nybomycin, a new antibiotic with antiphage and antibacterial properties", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 41, 1955, XP008156822
NADZAN,A.M. ET AL.: "Hydroxynybomycin: isolation, structure and bioactivity", THE JOURNAL OF ANTIBIOTICS, vol. 30, no. 6, 1977, pages 523 - 524, XP008156820
POPE,J.A. ET AL.: "Applications of thin layer chromatography, high performance liquid chromatography and mass spectrometry in the fermentation and isolation of the antibiotic nybomycin", JOURNAL OF INDUSTRIAL MICROBIOLOGY, vol. 6, no. 1, 1990, pages 61 - 69, XP008156827
"Frontiers in Antimicrobial Resistance", 2005, ASM PRESS AMERICAN SOCIETY FOR MICROBIOLOGY
JEVONS, M. P., BR MED J.S, 1961, pages 124 - 125
HIRAMATSU, K.; HANAKI, H. ET AL., J ANTIMICROB CHEMOTHER, vol. 40, no. 1, 1997, pages 135 - 6
PERICHON B; COURVALIN P, ANTIMICROB AGENTS CHEMOTHER, vol. 53, no. 11, 8 June 2009 (2009-06-08), pages 4580 - 7
STRELITZ F ET AL., PNAS, vol. 41, no. 9, 1955, pages 620 - 624
RINEHART KL JR ET AL., J AM CHEM SOC, vol. 92, no. 23, 1970, pages 6994 - 6995
NAGANAWA H ET AL., J ANTIBIOT, vol. 23, no. 7, 1970, pages 365 - 368
PERICHON B; COURVALIN P., ANTIMICROB AGENTS CHEMOTHER, vol. 53, no. 11, 8 June 2009 (2009-06-08), pages 4580 - 7
DIEP BA; GILL SR; CHANG RF; PHAN TH; CHEN JH; DAVIDSON MG; LIN F; LIN J; CARLETON HA; MONGODIN EF: "Perdreau-Remington F. Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus", LANCET, vol. 367, no. 9512, 4 March 2006 (2006-03-04), pages 731 - 9
"Frontiers in Antimicrobial Resistance.", 2005, ASM PRESS AMERICAN SOCIETY FOR MICROBIOLOGY
FUKUDA, H.; HORI, S. ET AL.: "Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus.", ANTIMICROB AGENTS CHEMOTHER, vol. 42, no. 8, 1998, pages 1917 - 22
SCHUHARDT VT ET AL., J BACTERIOL, vol. 6, no. 3, 9 September 1968 (1968-09-09), pages 734 - 7
WAYNE, PA: "Approved Standard", CLINICAL AND LABORATORY STANDARDS INSTITUTE, pages: M7 - A7
KURODA M ET AL., LANCET, vol. 357, no. 9264, 21 April 2001 (2001-04-21), pages 1225 - 40
BABA T ET AL., LANCET, vol. 359, no. 9320, 25 May 2002 (2002-05-25), pages 1819 - 27
NOVICK RP ET AL., J BACTERIOL, vol. 0, 9 August 1965 (1965-08-09), pages 467 - 80
GILL SR ET AL., J BACTERIOL, vol. 7, no. 7, 18 April 2005 (2005-04-18), pages 2426 - 38
DIEP BA ET AL., LANCET, vol. 367, no. 9512, 4 March 2006 (2006-03-04), pages 731 - 9
LULITANOND, A. ET AL., J CLIN MICROBIOL, vol. 47, no. 7, 29 April 2009 (2009-04-29), pages 2311 - 6
CUI, L.; MA, X. ET AL., J CLIN MICROBIOL, vol. 41, no. 1, 2003, pages 5 - 14
WANG, J. L.; TSENG, S. P. ET AL., EMERG INFECT DIS, vol. 10, no. 9, 2004, pages 1702 - 4
See also references of EP 2500022A4
STRELITZ,F. ET AL.: "Nybomycin, a new antibiotic with antiphage and antibacterial properties", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 41, 1955, XP008156822
NADZAN,A.M. ET AL.: "Hydroxynybomycin: isolation, structure and bioactivity", THE JOURNAL OF ANTIBIOTICS, vol. 30, no. 6, 1977, pages 523 - 524, XP008156820
POPE,J.A. ET AL.: "Applications of thin layer chromatography, high performance liquid chromatography and mass spectrometry in the fermentation and isolation of the antibiotic nybomycin", JOURNAL OF INDUSTRIAL MICROBIOLOGY, vol. 6, no. 1, 1990, pages 61 - 69, XP008156827
"Frontiers in Antimicrobial Resistance", 2005, ASM PRESS AMERICAN SOCIETY FOR MICROBIOLOGY
JEVONS, M. P., BR MED J.S, 1961, pages 124 - 125
HIRAMATSU, K.; HANAKI, H. ET AL., J ANTIMICROB CHEMOTHER, vol. 40, no. 1, 1997, pages 135 - 6
PERICHON B; COURVALIN P, ANTIMICROB AGENTS CHEMOTHER, vol. 53, no. 11, 8 June 2009 (2009-06-08), pages 4580 - 7
STRELITZ F ET AL., PNAS, vol. 41, no. 9, 1955, pages 620 - 624
RINEHART KL JR ET AL., J AM CHEM SOC, vol. 92, no. 23, 1970, pages 6994 - 6995
NAGANAWA H ET AL., J ANTIBIOT, vol. 23, no. 7, 1970, pages 365 - 368
PERICHON B; COURVALIN P., ANTIMICROB AGENTS CHEMOTHER, vol. 53, no. 11, 8 June 2009 (2009-06-08), pages 4580 - 7
DIEP BA; GILL SR; CHANG RF; PHAN TH; CHEN JH; DAVIDSON MG; LIN F; LIN J; CARLETON HA; MONGODIN EF: "Perdreau-Remington F. Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus", LANCET, vol. 367, no. 9512, 4 March 2006 (2006-03-04), pages 731 - 9
"Frontiers in Antimicrobial Resistance.", 2005, ASM PRESS AMERICAN SOCIETY FOR MICROBIOLOGY
FUKUDA, H.; HORI, S. ET AL.: "Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus.", ANTIMICROB AGENTS CHEMOTHER, vol. 42, no. 8, 1998, pages 1917 - 22
SCHUHARDT VT ET AL., J BACTERIOL, vol. 6, no. 3, 9 September 1968 (1968-09-09), pages 734 - 7
WAYNE, PA: "Approved Standard", CLINICAL AND LABORATORY STANDARDS INSTITUTE, pages: M7 - A7
KURODA M ET AL., LANCET, vol. 357, no. 9264, 21 April 2001 (2001-04-21), pages 1225 - 40
BABA T ET AL., LANCET, vol. 359, no. 9320, 25 May 2002 (2002-05-25), pages 1819 - 27
NOVICK RP ET AL., J BACTERIOL, vol. 0, 9 August 1965 (1965-08-09), pages 467 - 80
GILL SR ET AL., J BACTERIOL, vol. 7, no. 7, 18 April 2005 (2005-04-18), pages 2426 - 38
DIEP BA ET AL., LANCET, vol. 367, no. 9512, 4 March 2006 (2006-03-04), pages 731 - 9
LULITANOND, A. ET AL., J CLIN MICROBIOL, vol. 47, no. 7, 29 April 2009 (2009-04-29), pages 2311 - 6
CUI, L.; MA, X. ET AL., J CLIN MICROBIOL, vol. 41, no. 1, 2003, pages 5 - 14
WANG, J. L.; TSENG, S. P. ET AL., EMERG INFECT DIS, vol. 10, no. 9, 2004, pages 1702 - 4
See also references of EP 2500022A4
Attorney, Agent or Firm:
HIROTA, Koichi et al. (JP)
Koichi Hirota (JP)
Koichi Hirota (JP)
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