Title:
ANTIBACTERIAL AGENTS COMPRISING A PYRAZINO[2,3-B][1,4]OXAZIN-3-ONE OR A RELATED RING SYSTEM
Document Type and Number:
WIPO Patent Application WO/2017/029602
Kind Code:
A3
Abstract:
The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.
Inventors:
CUI HAIFENG (US)
HENNESSY ALAN (GB)
JIN QI (US)
MILES TIMOTHY JAMES (ES)
MOSS STEPHEN FREDERICK (GB)
PEARSON NEIL DAVID (US)
HENNESSY ALAN (GB)
JIN QI (US)
MILES TIMOTHY JAMES (ES)
MOSS STEPHEN FREDERICK (GB)
PEARSON NEIL DAVID (US)
Application Number:
PCT/IB2016/054890
Publication Date:
April 13, 2017
Filing Date:
August 15, 2016
Export Citation:
Assignee:
GLAXOSMITHKLINE IP DEV LTD (GB)
International Classes:
C07D498/04; A61K31/5383; A61K31/542; A61P31/04; C07D513/04; C07D519/00
Domestic Patent References:
| WO2010046388A1 | 2010-04-29 | |||
| WO2004002992A1 | 2004-01-08 | |||
| WO2004002490A2 | 2004-01-08 | |||
| WO2004087145A2 | 2004-10-14 | |||
| WO2006081264A1 | 2006-08-03 | |||
| WO2007093963A1 | 2007-08-23 | |||
| WO2008078305A2 | 2008-07-03 | |||
| WO2010055348A1 | 2010-05-20 | |||
| WO2008128961A1 | 2008-10-30 | |||
| WO2011148962A1 | 2011-12-01 |
Foreign References:
| US20090131444A1 | 2009-05-21 | |||
| US20100029623A1 | 2010-02-04 | |||
| US20090270374A1 | 2009-10-29 | |||
| US20140243302A1 | 2014-08-28 | |||
| JPS4632671B1 | 1971-09-23 |
Other References:
RECK FOLKERT ET AL: "Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity againstPseudomonas aeruginosa", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, no. 19, 4 August 2014 (2014-08-04), PERGAMON, GB, pages 5392 - 5409, XP029061970, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2014.07.040
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