Title:
ANTIBACTERIAL AGENTS
Document Type and Number:
WIPO Patent Application WO2004018414
Kind Code:
A3
Abstract:
The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof, wherein X=NH Y=CO, CS, -C(=N-CN) or X and Y together form an alkene, or C3-C5 cycloalkyl; R1 is -COOH; R2 is an electron withdrawing group; R4 is an optionally substituted aryl. The compounds of formula I are antibacterial agents that are useful for sterilization sanitation, antisepsis, and disinfection.
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Inventors:
THORARENSEN ATLI (US)
RUBLE CRAIG J (US)
ROMERO DONNA L (US)
RUBLE CRAIG J (US)
ROMERO DONNA L (US)
Application Number:
PCT/US2003/024797
Publication Date:
June 17, 2004
Filing Date:
August 22, 2003
Export Citation:
Assignee:
UPJOHN CO (US)
THORARENSEN ATLI (US)
RUBLE CRAIG J (US)
ROMERO DONNA L (US)
THORARENSEN ATLI (US)
RUBLE CRAIG J (US)
ROMERO DONNA L (US)
International Classes:
A61K31/195; A61P31/02; C07C235/42; C07C235/56; C07C235/84; C07C239/18; C07C239/20; C07C255/60; C07C311/16; C07C311/17; C07C311/21; C07C311/29; C07C311/38; C07C313/06; C07C313/24; C07C317/44; C07C323/60; C07C323/62; C07C323/63; C07C331/14; C07D205/04; C07D207/12; C07D207/26; C07D207/32; C07D207/40; C07D207/48; C07D209/08; C07D209/48; C07D211/96; C07D213/30; C07D213/32; C07D213/42; C07D213/76; C07D213/82; C07D215/14; C07D215/58; C07D217/08; C07D231/16; C07D231/56; C07D235/22; C07D249/14; C07D249/18; C07D263/32; C07D263/58; C07D265/26; C07D277/04; C07D277/74; C07D279/02; C07D295/192; C07D295/26; C07D307/33; C07D307/52; C07D307/68; C07D307/70; C07D309/12; C07D317/68; C07D319/18; C07D333/22; C07D333/24; C07D333/70; C07D335/16; C07D403/12; C07D405/06; C07D409/12; C07D413/12; C07D471/04; (IPC1-7): C07C311/16; A61K31/167; A61K31/18; A61K31/33; A61P31/02; C07C311/17; C07C311/21; C07D207/48; C07D209/08; C07D213/42; C07D215/58; C07D295/26; C07D307/52
Domestic Patent References:
| WO2003004458A1 | 2003-01-16 |
Foreign References:
| US4337270A | 1982-06-29 | |||
| DE570472C | 1933-02-17 | |||
| US3855285A | 1974-12-17 | |||
| DE278422C | ||||
| US3417058A | 1968-12-17 | |||
| FR1522956A | 1968-04-26 |
Other References:
DATABASE CHEMCATS AMERICAN CHEMICAL SOCIETY; XP002271081, retrieved from STN Database accession no. 2003:1951641
DATABASE REGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002271082, retrieved from STN
C.E. KASLOW ET AL, PROC. INDIANA ACAD. SCI., vol. 61, 1952, pages 121 - 125, XP001091388
G. FENTON ET AL, J. MED. CHEM., vol. 32, no. 1, 1989, pages 265 - 272, XP002271076
M. SÜSSE ET AL, J. PRAKT. CHEM., vol. 326, no. 6, 1984, pages 1027 - 1033, XP001091389
S.J. KANEWSKAJA, J. PRAKT. CHEM., vol. 2, no. 124, 1929, pages 33 - 47, XP001091392
V.S. PATEL ET AL, J. INDIAN CHEM. SOC., vol. 45, no. 2, 1968, pages 167 - 170, XP001091391
M. SUESSE ET AL, Z. CHEM., vol. 26, no. 5, 1986, pages 166 - 167, XP001091385
S.G. ABDEL-HAMIDE, J. INDIAN CHEM. SOC., vol. 74, no. 8, 1997, pages 613 - 618, XP001091384
H.J. MEHTA ET AL, J. INDIAN CHEM. SOC., vol. 47, no. 2, 1970, pages 125 - 130, XP001091387
DATABASE CAPLUS AMERICAN CHEMICAL SOCIETY; XP002271083, retrieved from STN Database accession no. 1970:68047
Y.K. YEE ET AL, J. MED. CHEM., vol. 43, no. 5, 2000, pages 873 - 882, XP002186965
DATABASE CAPLUS AMERICAN CHEMICAL SOCIETY; XP002271084, retrieved from STN Database accession no. 1999: 312695
DATABASE CAPLUS AMERICAN CHEMICAL SOCIETY; XP002271085, retrieved from STN Database accession no. 1979:456115
R.D. BARRY ET AL, J. HET. CHEM., vol. 9, no. 6, 1972, pages 1255 - 1257, XP001091390
DATABASE CAPLUS AMERICAN CHEMICAL SOCIETY; XP002271086, retrieved from STN Database accession no. 1962:12779
DATABASE CAPLUS AMERICAN CHEMICAL SOCIETY; XP002271087, retrieved from STN Database accession no. 1993:670811
DATABASE REGISTRY CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002271082, retrieved from STN
C.E. KASLOW ET AL, PROC. INDIANA ACAD. SCI., vol. 61, 1952, pages 121 - 125, XP001091388
G. FENTON ET AL, J. MED. CHEM., vol. 32, no. 1, 1989, pages 265 - 272, XP002271076
M. SÜSSE ET AL, J. PRAKT. CHEM., vol. 326, no. 6, 1984, pages 1027 - 1033, XP001091389
S.J. KANEWSKAJA, J. PRAKT. CHEM., vol. 2, no. 124, 1929, pages 33 - 47, XP001091392
V.S. PATEL ET AL, J. INDIAN CHEM. SOC., vol. 45, no. 2, 1968, pages 167 - 170, XP001091391
M. SUESSE ET AL, Z. CHEM., vol. 26, no. 5, 1986, pages 166 - 167, XP001091385
S.G. ABDEL-HAMIDE, J. INDIAN CHEM. SOC., vol. 74, no. 8, 1997, pages 613 - 618, XP001091384
H.J. MEHTA ET AL, J. INDIAN CHEM. SOC., vol. 47, no. 2, 1970, pages 125 - 130, XP001091387
DATABASE CAPLUS AMERICAN CHEMICAL SOCIETY; XP002271083, retrieved from STN Database accession no. 1970:68047
Y.K. YEE ET AL, J. MED. CHEM., vol. 43, no. 5, 2000, pages 873 - 882, XP002186965
DATABASE CAPLUS AMERICAN CHEMICAL SOCIETY; XP002271084, retrieved from STN Database accession no. 1999: 312695
DATABASE CAPLUS AMERICAN CHEMICAL SOCIETY; XP002271085, retrieved from STN Database accession no. 1979:456115
R.D. BARRY ET AL, J. HET. CHEM., vol. 9, no. 6, 1972, pages 1255 - 1257, XP001091390
DATABASE CAPLUS AMERICAN CHEMICAL SOCIETY; XP002271086, retrieved from STN Database accession no. 1962:12779
DATABASE CAPLUS AMERICAN CHEMICAL SOCIETY; XP002271087, retrieved from STN Database accession no. 1993:670811
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