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Title:
ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
Document Type and Number:
WIPO Patent Application WO/2011/044501
Kind Code:
A3
Abstract:
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q5, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Inventors:
AGGEN, James, Bradley (1311 California Drive, Burlingame, California, 94010, US)
DOZZO, Paola (7000 Shoreline Court, 3rd FloorSouth San Francisco, California, 94080, US)
GOLDBLUM, Adam, Aaron (3035 Ellis Street, Berkeley, California, 94703, US)
HILDEBRANDT, Darin, James (2020 Latham Street, Apt. 20Mountain View, California, 94040, US)
KANE, Timothy, Robert (136 Margarido Drive, Walnut Creek, California, 94596, US)
GLIEDT, Micah, James (1225 Balboa Court, Sunnyvale, California, 94086, US)
LINSELL, Martin, Sheringham (602 East 16th Avenue, San Mateo, California, 94402, US)
Application Number:
US2010/052043
Publication Date:
June 16, 2011
Filing Date:
October 08, 2010
Export Citation:
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Assignee:
ACHAOGEN, INC. (7000 Shoreline Court, 3rd FloorSouth San Francisco, California, 94080, US)
AGGEN, James, Bradley (1311 California Drive, Burlingame, California, 94010, US)
DOZZO, Paola (7000 Shoreline Court, 3rd FloorSouth San Francisco, California, 94080, US)
GOLDBLUM, Adam, Aaron (3035 Ellis Street, Berkeley, California, 94703, US)
HILDEBRANDT, Darin, James (2020 Latham Street, Apt. 20Mountain View, California, 94040, US)
KANE, Timothy, Robert (136 Margarido Drive, Walnut Creek, California, 94596, US)
GLIEDT, Micah, James (1225 Balboa Court, Sunnyvale, California, 94086, US)
LINSELL, Martin, Sheringham (602 East 16th Avenue, San Mateo, California, 94402, US)
International Classes:
C07H15/232; A61K31/7036; A61P31/04
Domestic Patent References:
WO2008124821A12008-10-16
WO2007064954A22007-06-07
Foreign References:
US3808198A1974-04-30
DE3044970A11981-09-03
US4247687A1981-01-27
Other References:
HANESSIAN, S. ET AL.: "Probing the ribosomal RNA A-site with functionally diverse analogues of paromomycin - synthesis of ring I mimetics", TETRAHEDRON, vol. 63, 2007, pages 827-846, XP002621093,
Attorney, Agent or Firm:
WAGNER, Emily, W. et al. (Seed Intellectual Property Law Group PLLC, Suite 5400701 Fifth Avenu, Seattle Washington, 98104-7064, US)
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