Title:
ANTIBACTERIAL OR ANTIFUNGAL PEPTIDE, AND ANTIBACTERIAL OR ANTIFUNGAL DRUG
Document Type and Number:
WIPO Patent Application WO/2019/009426
Kind Code:
A1
Abstract:
The present invention can provide: a low-molecular-weight peptide which has a potent antibacterial or antifungal activity that is not affected by the concentration of a salt and has extremely low toxicity to eukaryotic cells; an antibacterial or antifungal drug comprising the peptide; and others. A peptide (a), (b) or (c), or a derivative of the peptide, or a salt of the peptide or the derivative: (a) a peptide that contains the amino acid sequences respectively represented by SEQ ID NOs: 1 to 5; (b) a peptide that contains amino acid sequences respectively produced by deleting, substituting or adding one or several amino acid residues in the amino acid sequences respectively represented by SEQ ID NOs: 1 to 5 and has an antibacterial or antifungal activity; and (c) a peptide that contains an amino acid sequence having a 80% or more identity to the amino acid sequences respectively represented by SEQ ID NOs: 1 to 5 and has an antibacterial or antifungal activity.
Inventors:
OTSUKA YUICHI (JP)
MASUDA MICHIAKI (JP)
MASUDA MICHIAKI (JP)
Application Number:
PCT/JP2018/025798
Publication Date:
January 10, 2019
Filing Date:
July 02, 2018
Export Citation:
Assignee:
DOKKYO MEDICAL UNIV (JP)
International Classes:
C07K7/06; A61K38/04; A61P31/00; C07K5/103
Domestic Patent References:
| WO2012006187A2 | 2012-01-12 |
Foreign References:
| JP2001233899A | 2001-08-28 | |||
| JPH0770187A | 1995-03-14 | |||
| JP2005318829A | 2005-11-17 |
Other References:
SHIGERI YASUSHI ET AL.: "Identification of novel peptides from amphibian (Xenopus tropicalis) skin by direct tissue MALDI-MS analysis", FEBS JOURNAL, vol. 282, 2015, pages 102 - 113, XP055677199
FEDDERS HENNING ET AL.: "An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis", BIOCHEMICAL JOURNAL, vol. 416, 2008, pages 65 - 75, XP055677201
LU ZEKUAN ET AL.: "Novel cathelicidin-derived antimicrobial peptides from Equus asinus", FEBS JOURNAL, vol. 277, 2010, pages 2329 - 2339, XP0556773380
DUBOVSKII PETER V. ET AL.: "Novel lynx spider toxin shares common molecular architecture with defense peptides from frog skin", FEBS JOURNAL, vol. 278, 2011, pages 4382 - 4393, XP055677340
WEN JIA ET AL.: "The 5' UTR of the type 1 toxin ZorO can both inhibit and enhance translation", NUCLEIC ACIDS RESEARCH, vol. 45, no. 7, 2016, pages 4006 - 4020, XP055677343
ROELANTS KIM ET AL.: "Origin and Functional Diversification of an Amphibian Defense Petide Arsenal", PLOS GENETICS, vol. 9, no. 8, 2013, pages 1 - 16, XP055677344
SCOCCHI MARCO ET AL.: "Novel cathelicidins in horse leukocytes", FEBS LETTERS, vol. 457, 1999, pages 459 - 464, XP004260202, DOI: 10.1016/S0014-5793(99)01097-2
OYAMA LINDA B. ET AL.: "The rumen microbiome: an underexplored resource for novel antimicrobial discovery", NPJ BIOFILMS AND MICROBIOMES, vol. 3, December 2017 (2017-12-01), pages 33, XP055451361, DOI: 10.1038/s41522-017-0042-1
FEDDERS HENNING ET AL.: "An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis", BIOCHEMICAL JOURNAL, vol. 416, 2008, pages 65 - 75, XP055677201
LU ZEKUAN ET AL.: "Novel cathelicidin-derived antimicrobial peptides from Equus asinus", FEBS JOURNAL, vol. 277, 2010, pages 2329 - 2339, XP0556773380
DUBOVSKII PETER V. ET AL.: "Novel lynx spider toxin shares common molecular architecture with defense peptides from frog skin", FEBS JOURNAL, vol. 278, 2011, pages 4382 - 4393, XP055677340
WEN JIA ET AL.: "The 5' UTR of the type 1 toxin ZorO can both inhibit and enhance translation", NUCLEIC ACIDS RESEARCH, vol. 45, no. 7, 2016, pages 4006 - 4020, XP055677343
ROELANTS KIM ET AL.: "Origin and Functional Diversification of an Amphibian Defense Petide Arsenal", PLOS GENETICS, vol. 9, no. 8, 2013, pages 1 - 16, XP055677344
SCOCCHI MARCO ET AL.: "Novel cathelicidins in horse leukocytes", FEBS LETTERS, vol. 457, 1999, pages 459 - 464, XP004260202, DOI: 10.1016/S0014-5793(99)01097-2
OYAMA LINDA B. ET AL.: "The rumen microbiome: an underexplored resource for novel antimicrobial discovery", NPJ BIOFILMS AND MICROBIOMES, vol. 3, December 2017 (2017-12-01), pages 33, XP055451361, DOI: 10.1038/s41522-017-0042-1
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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