METHOD FOR REDUCING ACNE OR IMPROVING SKIN TONE CLAIM OF PRIORITY This application claims priority of U. S. Patent Application Serial No. 10/017,180 filed December 7,2001 which is a continuation-in-part of U. S. Patent Application Serial No. 10/012,627, filed December 7,2001, the disclosures of which are hereby incorporated by reference.

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to methods for (1) reducing the number and severity of acne lesions on the skin of a mammal; (2) ameliorating the inflammation of acne lesions on the skin of a mammal ; (3) improving the skin tone of a mammal, (4) treating skin disorders; (5) treating stress related skin diseases; (6) reducing stress and improving the emotional well being of an acne sufferer; (7) reducing sebaceous gland output; and (8) increasins compliance of the administration of anti-acne products. The method comprises the administration of a sensory regimen in an amount effective to downregulate the activity of the hypothalamus-pituitary-adrenal (HPA) axis in combination with the administration of an anti-acne composition.

2. Description of the Prior Art Advances in technology in the last century have brought benefits to society but have resulted in greater prevalence of stress in the daily lives of people at all levels of society. Our stress response mechanisms have not adapted at the same pace as advancing technology. The effect of stress on health and well being is well documented in"Why Zebra's Don't Get Ulcers-An Updated Guide to Stress, Stress Related Diseases and Coping"by Robert M. Sapolsky, ISBN 0-7167-3210-6, Chapter 1, (5th Edition 2000) and in"The Concepts of Stress and Stress System Disorders-Overview of Physical and Behavioral Homeostasis", JAMA, March 4,1992, Vol. 267, No. 9. For

Detailed Description of the Invention The present invention relates to an antibacterial cleaning wipe for hard surfaces which comprises: (a) 20 wt. % to 30 wt. % of a nonwoven fabric which consists of at least polyester fibers and viscose fibers and preferably consists of 60 wt. % to 95 wt. % of wood pulp fibers, 2.5 wt. % to 20 wt. % of viscose fibers and 2.5 wt. % to 20 wt. % of polyester fibers; and (b) 70 wt. % to 80 wt. % of a liquid cleaning composition being impregnated in said nonwoven fabric, wherein said liquid cleaning composition comprises: (i) 0.1 wt. % to 5 wt. %, more preferably 0.25 wt. % to 4 wt. % of a zwitterionic surfactant; (ii) 0.25 wt. % to 10 wt. %, more preferably 0.5 wt. % to 6 wt. % of a C1-C4 alkanol ; (iii) 0.5 wt. % to 8 wt. %, more preferably 1 wt. % to 5 wt. % of a cosurfactant; (iv) 0.1 wt. % to 2 wt. %, more preferably 0.2 wt. % to 1.4 wt. % of a disinfecting agent; (vi) 0 to 1.0 wt. %, more preferably 0.8 wt. % to 0.1 wt. % of a perfume; (vii) 0.5 wt. % to 8 wt. %, more preferably 1.0 wt. % to 6 wt. % of at least one ethoxylated nonionic surfactant; and (viii) the balance being water, wherein the composition has a pH of 5.5 to 7, more preferably 5.8 to 6.6.

The present invention also relates to an antibacterial cleaning wipe for hard surfaces which comprises: (a) 20 wt. % to 30 wt. % of a nonwoven fabric which consists of at least polyester fibers and viscose fibers and preferably consists of 60 wt. % to 95 wt. % of wood pulp fibers, 2.5 wt. % to 20 wt. % of viscose fibers and 2.5 wt. % to 20 wt. % of polyester fibers; and

(b) 70 wt. % to 80 wt. % of a liquid cleaning composition being impregnated in said nonwoven wherein said liquid cleaning composition comprises: (i) from 0 to 10 wt. % of a nonionic surfactant formed from a Cg-C18 alkanol and 6 to 9, preferably 7 to 8.5 moles of ethylene oxide; (ii) 0.1 wt. % to 4 wt. % of an ethoxylated nonionic surfactant formed from a Cg-C11 alkanol and 2 to 3 moles of ethylene oxide; (iii) 0.1 wt. % to 10 wt. % of a zwitterionic surfactant; (iv) from 0 to 5 wt. %, more preferably 0.1 wt. % to 3 wt. % of an anionic surfactant (v) from 0 to 4 wt. %, more preferably 0.1 wt. % to 1 wt. % of at least one disinfecting agent such as triclosan, essential oil or perfume; (vi) 0.1 wt. % to 5 wt. %, more preferably 0.3 wt. % to 3 wt. % of a proton donating agent; (vii) 0 to 6 wt. % of at least a water soluble solvent which is a C1-C4 alkanol ; (viii) 0.1 wt. % to 1.0 wt. % of triethanol amine; (ix) 1 wt. % to 10 wt. % of a blend of water soluble glycol ethers; and (x) the balance being water, wherein the composition has a pH of 2.5 to 4.7.

The water-soluble zwitterionic surfactant (betaine), which is used in the instant cleaning composition and provides good foaming properties and mildness to the composition. The zwitterionic surfactant is a water soluble betaine having the general formula: R2 + R I-tR4-X R3 wherein X-is selected from the group consisting of S03'and C02-and Rl is an alkyl group having 10 to 20 carbon atoms, preferably 12 to 16 carbon atoms, or the amido radical :

wherein R is an alkyl group having 9 to 19 carbon atoms and a is the integer 1 to 4; R2 and R3 are each alkyl groups having 1 to 3 carbons and preferably 1 carbon; R4 is an alkylen or hydroxyalkylene group having from 1 to 4 carbon atoms and, optionally, one hydroxyl group. Typical alkyldimethyl betaines include decyl dimethyl betaine or 2- (N- decyl-N, N-dimethyl-ammonia) acetate, coco dimethyl betaine or 2- (N-coco N, N- dimethylammonia) acetate, myristyl dimethyl betaine, palmityl dimethyl betaine, lauryl dimethyl betaine, cetyl dimethyl betaine, stearyl dimethyl betaine, etc. The amidobetaines similarly include cocoamidoethylbetaine, cocoamidopropyl betaine and the like. A preferred betaine is coco (Cg-C18) amidopropyl dimethyl betaine.

As used herein and in the appended claims the term"perfume"is used in its ordinary sense to refer to and include any non-water soluble fragrant substance or mixture of substances including natural (i. e. , obtained by extraction of flower, herb, blossom or plant), artificial (i. e. , mixture of natural oils or oil constituents) and synthetically produced substance) odoriferous substances. Typically, perfumes are complex mixtures of blends of various organic compounds such as alcohols, aldehydes, ethers, aromatic compounds and varying amounts of essential oils (e. g., terpenes) such as from 0% to 80%, usually from 10% to 70% by weight, the essential oils themselves being volatile odoriferous compounds and also serving to dissolve the other components of the perfume.

In the present invention the precise composition of the perfume is of no particular consequence to cleaning performance so long as it meets the criteria of water immiscibility and having a pleasing odor. Naturally, of course, especially for cleaning compositions intended for use in the home, the perfume, as well as all other ingredients, should be cosmetically acceptable, i. e. , non-toxic, hypoallergenic, etc..

The water soluble nonionic surfactants utilized in this invention are commercially well known and include the primary aliphatic alcohol ethoxylates, secondary aliphatic alcohol ethoxylates, alkylphenol ethoxylates and ethylene-oxide-propylene oxide

condensates on primary alkanols, such a Plurafacs (BASF) and condensates of ethylene oxide with sorbitan fatty acid esters such as the Tweens (ICI). The nonionic synthetic organic detergents generally are the condensation products of an organic aliphatic or alkyl aromatic hydrophobic compound and hydrophilic ethylene oxide groups. Practically any hydrophobic compound having a carboxy, hydroxy, amido, or amino group with a free hydrogen attached to the nitrogen can be condensed with ethylene oxide or with the polyhydration product thereof, polyethylene glycol, to form a water-soluble nonionic detergent. Further, the length of the polyethenoxy chain can be adjusted to achieve the desired balance between the hydrophobic and hydrophilic elements.

The nonionic detergent class includes the condensation products of a higher alcohol (e. g. , an alkanol containing 8 to 18 carbon atoms in a straight or branched chain configuration) condensed with 5 to 30 moles of ethylene oxide, for example, lauryl or myristyl alcohol condensed with 16 moles of ethylene oxide (EO), tridecanol condensed with 6 to moles of EO, myristyl alcohol condensed with 10 moles of EO per mole of myristyl alcohol, the condensation product of EO with a cut of coconut fatty alcohol containing a mixture of fatty alcohols with alkyl chains varying from 10 to 14 carbon atoms in length and wherein the condensate contains either 6 moles of EO per mole of total alcohol or 9 moles of EO per mole of alcohol and tallow alcohol ethoxylates containing 6 EO to 11 EO per mole of alcohol.

A preferred group of the foregoing nonionic surfactants are the Neodol ethoxylates (Shell Co. ), which are higher aliphatic, primary alcohol containing 9-15 carbon atoms, such as Cg-C1 1 alkanol condensed with 2.5 to 10 moles of ethylene oxide (NEODOL 91-2.5 or-5 or-6 or-8), Cl 2-13 alkanol condensed with 6.5 moles ethylene oxide (Neodol 23-6.5), C12 2-15 alkanol condensed with 12 moles ethylene oxide (Neodol 25-12), C14-15 alkanol condensed with 13 moles ethylene oxide (Neodol 45-13), and the like.

An especially preferred nonionic system comprises the mixture of a nonionic surfactant formed from a Cg-C1 1 alkanol condensed with 2 to 3.5 moles of ethylene

oxide (Cg-11 alcohol EO 2 to 3.5 : 1) with a nonionic surfactant formed from a Cg-C11 alkanol condensed with 7 to 9 moles of ethylene oxide (Cg-Cl 1 alcohol EO 7 to 9: 1), wherein the weight ratio of the Cg-C11 alcohol EO 7 to 9: 1 to the Cg-Cl 1 alcohol EO 2 to 3.5 : 1 is from 8: 1 to 1: 1 from preferably 6: 1 to 3: 1.

Additional satisfactory water soluble alcohol ethylene oxide condensates are the condensation products of a secondary aliphatic alcohol containing 8 to 18 carbon atoms in a straight or branched chain configuration condensed with 5 to 30 moles of ethylene oxide. Examples of commercially available nonionic detergents of the foregoing type are Cl 1-Cl 5 secondary alkanol condensed with either 9 EO (Tergitol 15-S-9) or 12 EO (Tergitol 15-S-12) marketed by Union Carbide.

Other suitable nonionic detergents include the polyethylene oxide condensates of one mole of alkyl phenol containing from 8 to 18 carbon atoms in a straight-or branched chain alkyl group with 5 to 30 moles of ethylene oxide. Specific examples of alkyl phenol ethoxylates include nonyl phenol condensed with 9.5 moles of EO per mole of nonyl phenol, dinonyl phenol condensed with 12 moles of EO per mole of phenol, dinonyl phenol condensed with 15 moles of EO per mole of phenol and di- isoctylphenol condensed with 15 moles of EO per mole of phenol. Commercially available nonionic surfactants of this type include Igepal CO-630 (nonyl phenol ethoxylate) marketed by GAF Corporation.

Also among the satisfactory nonionic detergents are the water-soluble condensation products of a Cg-C20 alkanol with a heteric mixture of ethylene oxide and propylene oxide wherein the weight ratio of ethylene oxide to propylene oxide is from 2.5 : 1 to 4: 1, preferably 2.8 : 1 to 3.3 : 1, with the total of the ethylene oxide and propylene oxide (including the terminal ethanol or propanol group) being from 60-85%, preferably 70-80%, by weight. Such detergents are commercially available from BASF-Wyandotte and a particularly preferred detergent is a C10-C16 alkanol condensate with ethylene oxide and propylene oxide, the weight ratio of ethylene oxide to propylene oxide being 3: 1 and the total alkoxy content being 75% by weight.

Condensates of 2 to 30 moles of ethylene oxide with sorbitan mono-and tri-Cl 0- C20 alkanoic acid esters having a HLB of 8 to 15 also may be employed as the nonionic detergent ingredient in the described composition. These surfactants are well known and are available from Imperial Chemical Industries under the Tween trade name. Suitable surfactants include polyoxyethylene (4) sorbitan monolaurate, polyoxyethylene (4) sorbitan monostearate, polyoxyethylene (20) sorbitan trioleate and polyoxyethylene (20) sorbitan tristearate.

Other suitable water-soluble nonionic detergents are marketed under the trade name"Pluronics". The compounds are formed by condensing ethylene oxide with a hydrophobic base formed by the condensation of propylene oxide with propylene glycol. The molecular weight of the hydrophobic portion of the molecule is of the order of 950 to 4000 and preferably 200 to 2,500. The addition of polyoxyethylene radicals to the hydrophobic portion tends to increase the solubility of the molecule as a whole so as to make the surfactant water-soluble. The molecular weight of the block polymers varies from 1,000 to 15,000 and the polyethylene oxide content may comprise 20% to 80% by weight. Preferably, these surfactants will be in liquid form and satisfactory surfactants are available as grades L 62 and L 64.

The disinfectant agent used in the instant composition is selected from the group consisting of C8-C16 alkyl amines, Cg-C16 alkyl benzyl dimethyl ammonium chlorides, Cg-C16 dialkyl dimethyl ammonium chlories, C8-C16 alkyl, Cg-C14 alkyl dimethyl ammonium chloride and chlorhexidine and mixtures thereof. The disinfecting agent can also be triclosan, an essential oil or perfume.

Some typical disinfectant agent useful in the instant compositions are tetra alkyl or trialkyl benzyl ammonium salts which are manufactured by Lonza, S. A. They are: Bardac 2180 (or 2170) which is N-decyl-N-isononyl-N, N-dimethyl ammonium chloride ; Bardac 22 which is didecyl dimethyl ammonium chloride ; Bardac LF which is N, Ndioctyl-N, N-dimethyl ammonium chloride ; Bardac 114 which is a mixture in a ratio of 1: 1: 1 of N-didecyl-N, N-dimethyl ammonium chloride/N-alkyl-N-ethyl phenylmethyl-N,

N-dimethyl-N-ethyl ammonium chloride; and Barquat MB-50 which is N-alkyl-N, N- dimethyl-N-benzyl ammonium chloride.

The cosurfactants in the instant compositions are selected from the group consisting of polypropylene glycol of the formula HO (CH3CHCH20) nH wherein n is a number from 1 to 18, and mono and di C1-C6 alkyl ethers and esters of ethylene glycol and propylene glycol having the structural formulas R (X) nOH, R1 (X) nOH, R (X) nOR and R1 (X) nOR1 wherein R is C1-C6 alkyl group, Ri is C2-C4 acyl group, X is (OCH2CH2) or (OCH2 (CH3) CH) and n is a number from 1 to 4, diethylene glycol, triethylene glycol, an alkyl lactate, wherein the alkyl group has 1 to 6 carbon atoms, 1 methoxy-2-propanol, 1 methoxy-3-propanol, and 1 methoxy 2-, 3-or 4-butanol.

Representative members of the polypropylene glycol include dipropylene glycol and polypropylene glycol having a molecular weight of 150 to 1000, e. g. , polypropylene glycol 400. Satisfactory glycol ethers are ethylene glycol monobutyl ether (butyl cellosolve), diethylene glycol monobutyl ether (butyl carbitol), triethylene glycol monobutyl ether, mono, di, tri propylene glycol monobutyl ether, tetraethylene glycol monobutyl ether, mono, di, tripropylene glycol monomethyl ether, propylene glycol monomethyl ether, ethylene glycol monohexyl ether, diethylene glycol monohexyl ether, propylene glycol tertiary butyl ether, ethylene glycol monoethyl ether, ethylene glycol monomethyl ether, ethylene glycol monopropyl ether, ethylene glycol monopentyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monopentyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, triethylene glycol monopropyl ether, triethylene glycol monopentyl ether, triethylene glycol monohexyl ether, mono, di, tripropylene glycol monoethyl ether, mono, di tripropylene glycol monopropyl ether, mono, di, tripropylene glycol monopentyl ether, mono, di, tripropylene glycol monohexyl ether, mono, di, tributylene glycol mono methyl ether, mono, di, tributylene glycol monoethyl ether, mono, di, tributylene glycol monopropyl ether, mono, di, tributylene glycol monobutyl ether, mono, di, tributylene glycol monopentyl ether and mono, di, tributylene glycol monohexyl ether, ethylene glycol

monoacetate and dipropylene glycol propionate. While all of the aforementioned glycol ether compounds provide the described stability, the most preferred cosurfactant is propylene glycol N-butyl ether.

The preferred Cl-C4 alkanols are ethanol or isopropanol and mixtures thereof.

The proton donating agent that can be used in the instant composition is selected from the group consisting of organic acids and inorganic acids and mixtures thereof. The organic acids are selected from the group consisting of mono-and di- aliphatic carboxylic acids and hydroxy containing organic acids and mixtures thereof.

Typical organic acids are adipic acid, succinic acid, lactic acid, glycolic acid, salicylic acid, tartaric acid and ortho hydroxy benzoic acid. Typical inorganic acids are sulfuric acid, nitric acid and hydrochloric acid.

The final essential ingredient in the instant composition is water. The proportion of water in the compositions generally is in the range of 70 wt. % to 98.5 wt. %.

The cleaning composition of this invention may, if desired, also contain other components either to provide additional effect or to make the product more attractive to the consumer. The following are mentioned by way of example: Colors or dyes in amounts up to 0.5% by weight; preservatives or antioxidizing agents, such as iodo propynyl butyl carbamate, formalin, 5-bromo-5-nitro-dioxan-1,3 ; 5-chloro-2-methyl-4- isothaliazolin-3-one, 2,6-di-tert. butyl-p-cresol, etc. , in amounts up to 2% by weight; and pH adjusting agents, such as sulfuric acid or sodium hydroxide, as needed.

The cleaning compositions are prepared by simple batch mixing at 25°C-30°C.

The nonwoven fabric is impregnated with the liquid cleaning composition by means of a positive impregnation process. The liquid is positively fed into the nonwoven fabric through a controlled gear pump and injection bar at a ratio of 2.5-3 grams of liquid cleaning composition to 1 gram of the nonwoven fabric.

The nonwoven fabric is formed from 10 wt. % to 90 wt. % of viscose fibers and 10 wt. % to 90 wt. % of polyester fibers such as Spunlace made by the Dexter Corporation. More preferably the nonwoven fabric comprises 10 wt. % to 95 wt. % of wood pulp fibers, 1 wt. % to 40 wt. % of viscose fibers and 1 wt. % to 40 wt. % of

polyester fibers. Such a nonwoven fabric which is manufactured by Dexter Corporation under the name Hydraspun comprises 60% to 95% of wood pulp fabrics, 2.5 wt. % to 20 wt. % of viscose fibers and 2.5 wt. % to 20 wt. % of polyester fibers.

The following examples illustrate liquid cleaning compositions of the described invention. The exemplified compositions are illustrative only and do not limit the scope of the invention. Unless otherwise specified, the proportions in the examples and elsewhere in the specification are by weight.

Example 1 The following cleaning wipes were made by the aforementioned process. A B Part I Wt. % Wt. % Propylene glycol N-butyl ether 3. 0 3.0 Ethanol 1.0 1.0 Cocoamido propyl dimethyl betaine 2. 0 2.0 C9-C11 alcohol E07. 5-8: 1 nonionic 2. 0 2.0 Perfume 0. 6 0.6 C9-C11 alcohol E02. 5: 1 nonionic 0. 37 0.37 Bardac 2170 0. 72 0.72 Water Bal. Bal. Part II Part I 73.68 73.68 S unlace 26. 32 Hydraspun 8579 26. 32

Formulas A and B were tested for cleaning performance on Perspex tiles and rated on a 10 point scale (0 = very poor/much residue and 10 = very good/no residue).

A B Residue score 2.4 3.7 15cm x 15 cm Perspex black tiles are wiped with the impregnated test substrate in a circular movement such that the middle of the tile is wet and contours kept dry.

Each test product is applied on 5 different tiles (= 5 replicates), then 5 judges score the residue pattern (observation made under indirect light conditions) of each tile from 0= very poor residue score up to 10= excellent, no residue on a 10 point scale.

Results are then analyzed statistically.

Example 2 The following cleaning wipes were made by the aforementioned process: 1 2 3 Lactic acid 1. 5 1 1.5 C9-C11 alcohol EO 2.5 : 1 nonionic surfactant 0. 2 0.2 0.2 C13-17 Parafin sulfonate 1. 2 1.2 0.6 Diethylene glycol N-butyl ether 2 2 2 Cocoamido propyl dimethyl betaine 0. 45 0.45 0.45 Propylene glycol n-butyl ether 2 2 2 Ethanol 2 2 2 Triethanol amine 0. 8 0.57 1.0 Perfume 0. 4 0.4 0.4 Water Bal. Bal. Bal. Part II Part I 73.68 73. 68 73. 68 Spunlace 26. 32 26.32 Hydraspun 8579 26.32