ANTIBACTERIAL COMPOSITION

WIPO Patent Application WO/2023/048337

A1

The present specification relates to a compound represented by chemical formula 1, a salt, a stereoisomer, a solvent or a hydrate thereof, an antibacterial composition, a composition for inhibiting bacterial infections, a composition for preventing, alleviating or treating bacterial infectious diseases, and a composition for preventing, alleviating or treating inflammation caused by a bacterial infection. The composition containing, as an active ingredient, a compound represented by chemical formula 1 or a salt, a stereoisomer, a solvent or a hydrate thereof, according to one aspect of the present invention, specifically binds to p62 protein so as to activate p62, thereby increasing the activity of autophagy, which is inhibited by a bacterial infection, and thus has antibacterial activity against various bacteria, can inhibit bacterial infectivity and has the excellent effect of enabling prevention, alleviation or treatment of bacterial infectious diseases and inflammation caused by an infection. Therefore, the composition can be effectively used in therapeutic agents, food, food additives, feed additives, disinfectants, cosmetics and the like.

KWON YONG TAE (KR)
LEE YOON JEE (KR)
JI CHANG HOON (KR)
JUNG CHAN HOON (KR)
JUNG CHANG AN (KR)
KOH AH RA (KR)
KIM HYE YEON (KR)

PCT/KR2021/017547

March 30, 2023

November 25, 2021

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SEOUL NAT UNIV R&DB FOUNDATION (KR)
AUTOTAC INC (KR)

C07D207/08; A23L33/10; A61K8/41; A61K8/42; A61K8/49; A61K31/138; A61K31/166; A61K31/40; A61P31/04; A61Q17/00

WO2020256444A1

2020-12-24

US20160257642A1	2016-09-08
KR20200011389A	2020-02-03

KEITH D. GREEN, WENJING CHEN, SYLVIE GARNEAU-TSODIKOVA: "Identification and Characterization of Inhibitors of the Aminoglycoside Resistance Acetyltransferase Eis from Mycobacterium tuberculosis", CHEMMEDCHEM, WILEY-VCH, vol. 7, no. 1, 2 January 2012 (2012-01-02), pages 73 - 77, XP055096266, ISSN: 18607179, DOI: 10.1002/cmdc.201100332
CAMILA G. DE ALMEIDA; SAMIRA G. REIS; ANGELINA M. DE ALMEIDA; CLAUDIO G. DINIZ; VÂNIA L. DA SILVA; MIREILLE LE HYARIC: "Synthesis and Antibacterial Activity of Aromatic and Heteroaromatic Amino Alcohols", CHEMICAL BIOLOGY & DRUG DESIGN, BLACKWELL MUNKSGAARD, HOBOKEN, USA, vol. 78, no. 5, 21 September 2011 (2011-09-21), Hoboken, USA, pages 876 - 880, XP072379109, ISSN: 1747-0277, DOI: 10.1111/j.1747-0285.2011.01231.x
YOON JEE LEE, JIN KYUNG KIM, CHAN HOON JUNG, YOUNG JAE KIM, JU YOUNG KIM, EUI JUNG JUNG, YEON SUNG SON, SANG MI SHIM, HYUN TAE KIM: "F-21 Degradation of intracellular Bacteria by p62/SQSTM1-mediated Xenophagy", KSBMB INTERNATIONAL CONFERENCE 2021, 25-27 MAY 2021, BEXCO, BUSAN, KOREA, KOREA SOCIETY OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, KOREA, 25 May 2021 (2021-05-25) - 27 May 2021 (2021-05-27), Korea, pages 181, XP009545484

KIM, Min-jung (KR)

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