ANTIBACTERIAL PEPTIDE TARGETING MYCOBACTERIUM TUBERCULOSIS TOXIN-ANTITOXIN SYSTEM, AND USE THEREOF

WIPO Patent Application WO/2016/195336

A1

The present invention relates to an antibacterial peptide targeting a Mycobacterium tuberculosis toxin-antitoxin system, and a use thereof. Specifically, a peptide having the amino acid sequence represented by SEQ ID NOs: 4-6, inhibiting Mycobacterium tuberculosis toxin-antitoxin binding, inhibits the binding of a Mycobacterium tuberculosis toxin-antitoxin complex while not affecting the active site of toxins, thereby decomposing initiation tRNA by isolated toxins so as to induce the death of Mycobacterium tuberculosis, and thus the peptide inhibiting Mycobacterium tuberculosis toxin-antitoxin binding can be useful as an antibacterial composition.

LEE BONG-JIN (KR)
LEE IN-GYUN (KR)
LEE SANG JAE (KR)
LEE KI-YOUNG (KR)

PCT/KR2016/005657

December 08, 2016

May 27, 2016

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UNIV SEOUL NAT R & DB FOUND (KR)

A61K38/08; C07K7/06; A61K38/10; A61K38/16; C07K7/08; C07K14/35; C11D3/48; C11D9/40

KR20090013762A	2009-02-05
US20070298043A1	2007-12-27
US20110028697A1	2011-02-03
JP2007039398A	2007-02-15

DATABASE Genbank [O] 29 April 2014 (2014-04-29), XP055332822, Database accession no. KAY40319.1
LEE ET AL.: "Structural and Functional Studies of the Mycobacterium Tuberculosis VapBC30 Toxin-antitoxin System: Implications for the Design of Novel Antimicrobial Peptides", NUCLEIC ACIDS RESEARCH, vol. 43, no. 15, 6 July 2015 (2015-07-06), pages 7624 - 7637, XP055332825

LEE, WON-HEE (KR)
이원희 (KR)

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