Title:
ANTIBACTERIAL STENT HAVING MICRO-NANO DOUBLE-LAYER STRUCTURE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/138593
Kind Code:
A1
Abstract:
Provided in the present invention are an antibacterial stent having a micro-nano double-layer structure, and a preparation method therefor and the use thereof, which belong to the technical field of oral medical products. The method for preparing the antibacterial stent having a micro-nano double-layer structure provided by the present invention comprises the following steps: (1) mixing a polyhydroxyalkanoate material with a nano antibacterial drug, and dissolving same by means of adding an organic solvent so as to obtain a polyhydroxyalkanoate solution; (2) pouring the polyhydroxyalkanoate solution into a mold, immersing the mold filled with the polyhydroxyalkanoate solution in a poor solvent of the polyhydroxyalkanoate material, and performing solution replacement to obtain a semi-solid stent; and (3) freeze-drying the semi-solid stent to then obtain an antibacterial stent having a micro-nano double-layer structure. The antibacterial stent having a micro-nano double-layer structure provided by the present invention has good cell compatibility and a good antibacterial property, and can effectively promote adhesion and proliferation of gingival fibroblasts and reduce bacterial infection of wounds.
Inventors:
SUN YUCHUN (CN)
CHEN GUOQIANG (CN)
ZHANG XU (CN)
ZHOU YONGSHENG (CN)
WANG YONG (CN)
CHEN FANFAN (CN)
ZHAO ZIFAN (CN)
ZHAI WENRU (CN)
CHEN GUOQIANG (CN)
ZHANG XU (CN)
ZHOU YONGSHENG (CN)
WANG YONG (CN)
CHEN FANFAN (CN)
ZHAO ZIFAN (CN)
ZHAI WENRU (CN)
Application Number:
PCT/CN2023/072758
Publication Date:
July 27, 2023
Filing Date:
January 18, 2023
Export Citation:
Assignee:
PEKING UNIV SCHOOL AND HOSPITAL OF STOMATOLOGY (CN)
International Classes:
A61L27/56; A61K45/00; A61K47/34; A61L27/02; A61L27/04; A61L27/18; A61L27/40; A61L27/50; A61L27/54; A61P1/02; A61P31/04; B82Y5/00; B82Y40/00
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Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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