Title:
ANTIBACTERIAL SUBSTANCES INJURING BACTERIAL CELL MEMBARANE AND METHODS OF USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2006/075580
Kind Code:
A1
Abstract:
A monomer injuring bacterial cell membrane which is a compound having a carbon cycle structure or a carbon/oxygen heterocycle structure, carrying two or more amino-type functional groups attached to one side of the cycle plane and showing an affinity for phospholipids in the other side of the cycle plane and exhibits a bacteriostatic effect of injuring bacterial cell wall, i.e., injuring bacterial cell wall while allowing the bacterium to sustain its proliferating ability; an oligomer injuring bacterial cell membrane which consists of two or more units of the above monomer bonded to each other; an antimicrobial monomer injuring bacterial cell membrane showing an activity of injuring bacterial cell membrane and an antimicrobial activity which belongs to the monomer injuring bacterial cell membrane as described above and in which an amino-type functional group has an aromatic ring; an antimicrobial oligomer injuring bacterial cell membrane which consists of two or more units of the above monomer bonded to each other; and various antimicrobial methods using these substances. Thus, it becomes possible to provide substances injuring bacterial cell membrane and antimicrobial substances injuring bacterial cell membrane which can be easily produced and methods of effectively utilizing the same.
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Inventors:
YAMAMURA HATSUO (JP)
KAWAI MASAO (JP)
KATSU TAKASHI (JP)
KAWAI MASAO (JP)
KATSU TAKASHI (JP)
Application Number:
PCT/JP2006/300156
Publication Date:
July 20, 2006
Filing Date:
January 04, 2006
Export Citation:
Assignee:
NAT UNIV CORP NAGOYA INST TECH (JP)
UNIV OKAYAMA NAT UNIV CORP (JP)
YAMAMURA HATSUO (JP)
KAWAI MASAO (JP)
KATSU TAKASHI (JP)
UNIV OKAYAMA NAT UNIV CORP (JP)
YAMAMURA HATSUO (JP)
KAWAI MASAO (JP)
KATSU TAKASHI (JP)
International Classes:
C08B37/16; A61K31/7048; A61K31/724; A61P31/04; A61P43/00
Domestic Patent References:
| WO2005011710A1 | 2005-02-10 | |||
| WO1997049735A1 | 1997-12-31 |
Foreign References:
| JPS61501919A | 1986-09-04 | |||
| JPS5319392A | 1978-02-22 | |||
| JP2004506645A | 2004-03-04 | |||
| JP2002302569A | 2002-10-18 | |||
| JPH04227602A | 1992-08-17 | |||
| JPS52138580A | 1977-11-18 | |||
| JPS51142088A | 1976-12-07 | |||
| JPS4985015A | 1974-08-15 | |||
| JPS4985014A | 1974-08-15 | |||
| JP2003183296A | 2003-07-03 |
Other References:
WANG Z. ET AL.: "Per-6-substituted-per-6-deoxy beta-cyclodextrins Inhibit the Formation of beta-Amyloid Peptide Derived Soluble Oligomers", J. MED. CHEM., vol. 47, no. 13, 17 June 2004 (2004-06-17), pages 3329 - 3333, XP002305930
SEBESTA R. ET AL.: "Synthesis of New Aminoderivatives of beta-Cyclodextrin", ENANTIOMER, vol. 4, 1999, pages 271 - 277, XP002997172
UMEZAWA S. ET AL.: "Studies of Aminosugars. XVIII. Synthesis of Amino Derivatives of Schardinger alpha-Dextrin and Raffinose", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 41, no. 2, 1968, pages 464 - 468, XP002998572
SEBESTA R. ET AL.: "Synthesis of New Aminoderivatives of beta-Cyclodextrin", ENANTIOMER, vol. 4, 1999, pages 271 - 277, XP002997172
UMEZAWA S. ET AL.: "Studies of Aminosugars. XVIII. Synthesis of Amino Derivatives of Schardinger alpha-Dextrin and Raffinose", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 41, no. 2, 1968, pages 464 - 468, XP002998572
Attorney, Agent or Firm:
Kitagawa, Osamu (Third Floor Fujigaoka No.2 Asahi Bldg., 7,
Fujimigaoka, Meito-k, Nagoya-shi Aichi 48, JP)
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