Title:
ANTIBIOTIC DROSOCIN DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2006052129
Kind Code:
A3
Abstract:
The invention concerns derivatives of drosocin which have an increased half-life in mammalian serum by substituting one or more of the amino acid residues of wild type drosocin with another amino acid or a peptidomimetic moiety capable of replacing said amino acid. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition.
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Inventors:
VAN HOOFT PETRUS ALBERTUS VENA (NL)
NOORT DANIEL (NL)
DE VISSER PETER CHRISTIAN (NL)
OVERKLEEFT HERMAN STEVEN (NL)
VAN BOOM JACOBUS HUBERTUS (NL)
BIKKER FLORIS JACOB (NL)
NOORT DANIEL (NL)
DE VISSER PETER CHRISTIAN (NL)
OVERKLEEFT HERMAN STEVEN (NL)
VAN BOOM JACOBUS HUBERTUS (NL)
BIKKER FLORIS JACOB (NL)
Application Number:
PCT/NL2005/000790
Publication Date:
July 13, 2006
Filing Date:
November 10, 2005
Export Citation:
Assignee:
TNO (NL)
VAN HOOFT PETRUS ALBERTUS VENA (NL)
NOORT DANIEL (NL)
DE VISSER PETER CHRISTIAN (NL)
OVERKLEEFT HERMAN STEVEN (NL)
VAN BOOM JACOBUS HUBERTUS (NL)
BIKKER FLORIS JACOB (NL)
VAN HOOFT PETRUS ALBERTUS VENA (NL)
NOORT DANIEL (NL)
DE VISSER PETER CHRISTIAN (NL)
OVERKLEEFT HERMAN STEVEN (NL)
VAN BOOM JACOBUS HUBERTUS (NL)
BIKKER FLORIS JACOB (NL)
International Classes:
A61K38/14; C07K14/435; A61K38/17; C07K9/00
Domestic Patent References:
| WO1994005787A1 | 1994-03-17 | |||
| WO1999064611A1 | 1999-12-16 | |||
| WO2000017226A1 | 2000-03-30 |
Foreign References:
| US6503881B2 | 2003-01-07 |
Other References:
CUDIC M ET AL.: "In vitro and in vivo activity of an antibacterial peptide analog against uropathogens", PEPTIDES, vol. 24, 2003, pages 807 - 820, XP002329691
GOBBO M ET AL.: "Antimicrobial Peptides: Synthesis and Antibacterial Activity of Linear and Cyclic Drosocin and Apidaecin 1b Analogues", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 20, 2002, pages 4494 - 4504, XP002329692
BENCIVENGO A-M ET AL.: "The efficacy of the antibacterial peptide, pyrrhocoricin, is finely regulated by its amino acid residues and active domains", LETTERS IN PEPTIDE SCIENCE, vol. 8, 2002, pages 201 - 209, XP002329693
DE VISSER P C ET AL: "Biological evaluation of Tyr6 and Ser7 modified drosocin analogues", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 15, no. 11, 2 June 2005 (2005-06-02), pages 2902 - 2905, XP004906920, ISSN: 0960-894X
GOBBO M ET AL.: "Antimicrobial Peptides: Synthesis and Antibacterial Activity of Linear and Cyclic Drosocin and Apidaecin 1b Analogues", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 20, 2002, pages 4494 - 4504, XP002329692
BENCIVENGO A-M ET AL.: "The efficacy of the antibacterial peptide, pyrrhocoricin, is finely regulated by its amino acid residues and active domains", LETTERS IN PEPTIDE SCIENCE, vol. 8, 2002, pages 201 - 209, XP002329693
DE VISSER P C ET AL: "Biological evaluation of Tyr6 and Ser7 modified drosocin analogues", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 15, no. 11, 2 June 2005 (2005-06-02), pages 2902 - 2905, XP004906920, ISSN: 0960-894X
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