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Title:
ANTIBIOTIC OPHTHALMIC PREPARATION, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/051149
Kind Code:
A1
Abstract:
An antibiotic ophthalmic preparation, comprising the following raw materials in parts by weight: an active ingredient: 0.5-1.5 parts of an antibiotic; the content of the active ingredient in the ophthalmic preparation being 1-10 mg/mL; and pharmaceutically acceptable excipients: 1-10 parts of a surfactant, 0.5-5 parts of an emulsion stabilizer, 1-3 parts of a tackifier, and the balance of a solvent. The ophthalmic preparation can deliver antibiotics to the posterior segment of the eye in an eye drop administration manner, so as to solve the problem that it is difficult to treat endophthalmitis by means of eye drop administration. Moreover, a higher drug concentration can also be accumulated in the ocular surface, and an excellent inhibitory effect is also exhibited against some drug-resistant bacteria. A one-off solution and means are provided for endophthalmitis prophylactic treatment after clinical glaucoma surgery, cataract surgery or/and vitreous injection, and anterior segment infection treatment.

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Inventors:
DONG QING (CN)
ZHANG SHU (CN)
XUE LUBING (CN)
TANG XIN (CN)
Application Number:
PCT/CN2022/116433
Publication Date:
April 06, 2023
Filing Date:
September 01, 2022
Export Citation:
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Assignee:
CHENGDU RUIMU BIOMEDICAL TECH CO LTD (CN)
International Classes:
A61K9/10; A61K9/08; A61K31/4704; A61K47/30; A61K47/36; A61K47/38; A61P27/02; A61P31/00
Domestic Patent References:
WO2002015878A12002-02-28
Foreign References:
CN113797162A2021-12-17
CN107854469A2018-03-30
CN107837275A2018-03-27
CN107998399A2018-05-08
US20140378401A12014-12-25
CN1846787A2006-10-18
CN110664757A2020-01-10
Other References:
HONG, YUPING ET AL.: "(Non-official translation: Research Progress and Clinical Application of Quinolones for Topical Application (Review))", GUANGDONG PHARMACEUTICAL JOURNAL, vol. 11, no. 2, 31 December 2001 (2001-12-31), pages 5 - 7
MAO SHIRUI, YANG HONGTU; CHEN JIANMING; BI DIANZHOU: "Uses of Povidone in Pharmaceutics", JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY, vol. 14, no. 3, 20 July 1997 (1997-07-20), pages 224 - 230, XP055952034
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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