ANTIBIOTIC TKR2999, PROCESS FOR THE PREPARATION THEREOF AND MICROBE

Title:

ANTIBIOTIC TKR2999, PROCESS FOR THE PREPARATION THEREOF AND MICROBE

Document Type and Number:

WIPO Patent Application WO/1999/032498

Kind Code:

A1

Abstract:

Antibiotic TKR2999 having the following physicochemical properties: (1) the m/z value ([M+H]?+¿) is 971 as determined by FAB mass spectrometry, (2) the molecular formula is C¿44?H¿78?N¿10?O¿14? and the m/z value ([M+H]?+¿) is 971.5776 as determined by high-resolution FAB mass spectrometry, (3) the ultraviolet absorption spectrum (as determined in methanol) has a terminal absorption, (4) the main absorption wavenumbers (cm?-1¿) of infrared absorption spectrum (as determined by the KBr method) are 3320, 2920, 1680, 1540, 1210, 1140, 840, 800 and 720, (5) aspartic acid, threonine, serine, glycine, alanine, $g(b)-alanine and ornithine are detected in the amino acid analysis based on the ninhydrin reaction, and (6) it is soluble in methanol but difficultly soluble in hexane, chloroform and water; or pharmacologically acceptable salts thereof. These novel substances are useful as remedies for mycosis.

Inventors:

TAKESAKO KAZUTOH (JP)
AWAZU NAOYUKI (JP)
UENO MITSUHIRO (JP)
ONISHI YOSHIMI (JP)
KATO IKUNOSHIN (JP)

Application Number:

PCT/JP1998/005797

Publication Date:

July 01, 1999

Filing Date:

December 22, 1998

Export Citation:

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Assignee:

TAKARA SHUZO CO (JP)
TAKESAKO KAZUTOH (JP)
AWAZU NAOYUKI (JP)
UENO MITSUHIRO (JP)
ONISHI YOSHIMI (JP)
KATO IKUNOSHIN (JP)

International Classes:

A61P31/10; C07K4/00; C07K4/06; C12P21/02; A61K38/00; (IPC1-7): C07G11/00; C12P1/02; C12N1/14

Domestic Patent References:

WO1998056755A1	1998-12-17
WO1998021196A1	1998-05-22
WO1997034012A1	1997-09-18

Foreign References:

JPH09249680A

1997-09-22

Other References: