Title:
ANTIBIOTICS CONTAINING BORINIC ACID COMPLEXES AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2006007384
Kind Code:
A3
Abstract:
The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.
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Inventors:
LEE VING (US)
BENKOVIC STEPHEN J (US)
BAKER STEPHEN J (US)
MAPLES KIRK R (US)
AKAMA TSUTOMU (US)
ZHANG YONG-KANG (US)
SINGH RAJESHWAR (CA)
SAURO VITTORIO A (CA)
PANDIT CHETAN (CA)
SU ZHUOYI (CA)
YANG ZHIXIANG (CA)
BENKOVIC STEPHEN J (US)
BAKER STEPHEN J (US)
MAPLES KIRK R (US)
AKAMA TSUTOMU (US)
ZHANG YONG-KANG (US)
SINGH RAJESHWAR (CA)
SAURO VITTORIO A (CA)
PANDIT CHETAN (CA)
SU ZHUOYI (CA)
YANG ZHIXIANG (CA)
Application Number:
PCT/US2005/021214
Publication Date:
April 06, 2006
Filing Date:
June 14, 2005
Export Citation:
Assignee:
ANACOR PHARMACEUTICALS INC (US)
LEE VING (US)
BENKOVIC STEPHEN J (US)
BAKER STEPHEN J (US)
MAPLES KIRK R (US)
AKAMA TSUTOMU (US)
ZHANG YONG-KANG (US)
SINGH RAJESHWAR (CA)
SAURO VITTORIO A (CA)
PANDIT CHETAN (CA)
SU ZHUOYI (CA)
YANG ZHIXIANG (CA)
LEE VING (US)
BENKOVIC STEPHEN J (US)
BAKER STEPHEN J (US)
MAPLES KIRK R (US)
AKAMA TSUTOMU (US)
ZHANG YONG-KANG (US)
SINGH RAJESHWAR (CA)
SAURO VITTORIO A (CA)
PANDIT CHETAN (CA)
SU ZHUOYI (CA)
YANG ZHIXIANG (CA)
International Classes:
A61K31/69; A61P31/04; A61P31/10; C07F5/02; C07F5/04
Domestic Patent References:
| WO2004056322A2 | 2004-07-08 | |||
| WO2003059916A2 | 2003-07-24 | |||
| WO2000075142A2 | 2000-12-14 |
Foreign References:
| US20050070503A1 | 2005-03-31 | |||
| US20040224923A1 | 2004-11-11 | |||
| US5348948A | 1994-09-20 |
Other References:
CUI, YI ET AL: "Organoboron Compounds with an 8-Hydroxyquinolato Chelate and Its Derivatives: Substituent Effects on Structures and Luminescence", INORGANIC CHEMISTRY, vol. 44, no. 3, 7 February 2005 (2005-02-07), pages 601 - 609, XP002358128, ISSN: 0020-1669
QIN, YANG ET AL: "Luminescent Organoboron Quinolate Polymers", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 22, 9 June 2004 (2004-06-09), pages 7015 - 7018, XP002358129, ISSN: 0002-7863
MOEDER, CHARLES W. ET AL: "Kinetic analysis of the asymmetric amplification exhibited by B-chlorodiisopinocampheylborane", JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, vol. 17, no. 4, April 2004 (2004-04-01), pages 317 - 324, XP002358130, ISSN: 0894-3230
TABUCHI, HITOSHI ET AL: "Anticoccidial activity of some azacyclo organoborinates", HETEROCYCLES, vol. 60, no. 1, 2003, pages 177 - 182, XP001207975, ISSN: 0385-5414
GUO-ZHENG Y ET AL: "SINGLE SITE TRANSARYLATION OF 2,2'-DIMETALIZED-1,1'-BINAPHTHYL TO AMINOCLOROBORATES AND SYNTHESIS OF 2-BINAPHTHYL BORON COMPOUNDS", YOUJI HUAXUE / ORGANIC CHEMISTRY, SCIENCE PRESS, BEIJING, CN, vol. 16, no. 2, 1996, pages 139 - 144, XP002922569, ISSN: 0253-2786
BROWN, HERBERT C. ET AL: "Chiral synthesis via organoboranes. 35. Simple procedures for the efficient recycling of the terpenyl chiral auxiliaries and convenient isolation of the homoallylic alcohols in asymmetric allyl- and crotylboration of aldehydes", JOURNAL OF ORGANIC CHEMISTRY, vol. 57, no. 24, 1992, pages 6608 - 6614, XP002358131, ISSN: 0022-3263
FARFAN N ET AL: "THROUGH-BOND MODULATION ON N-B RING FORMATION SHOWN BY NMR AND X-RAY DIFFRACTION STUDIES OF BORATE DERIVATIVES OF PYRIDYL ALCOHOLS", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2, CHEMICAL SOCIETY. LETCHWORTH, GB, 1992, pages 527 - 532, XP002922571, ISSN: 1472-779X
ZIXING S ET AL: "SYNTHESIS OF AROMATIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES OF ASYMMETRIC DIARYLBORINIC ACIDS", WUHAN DAXUE XUEBAO - WUHAN UNIVERSITY JOURNAL, GAI KAN BIANJIBU, WUHAN,, CN, vol. 3, 1990, pages 67 - 71, XP002922573, ISSN: 1000-5374
BAILEY J ET AL: "BORON-CONTAINING ANTIBACTERIAL AGENTS: EFFECTS ON GROWTH AND MORPHOLOGY OF BACTERIA UNDER VARIOUS CULTURE CONDITIONS", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 17, no. 4, April 1980 (1980-04-01), pages 549 - 553, XP002922581, ISSN: 0066-4804
KOSTER, ROLAND ET AL: "Boron compounds, XXXIX. Alkenoxy(diorganyl)boranes substituted at the alkenoxy group from 2-methylacrolein and triorganylboranes", JUSTUS LIEBIGS ANNALEN DER CHEMIE, no. 6, 1976, pages 1116 - 1134, XP009058269, ISSN: 0075-4617
TOPORCER, LOUIS H. ET AL: "Preparation and properties of some tetracoordinate boron compounds. The pseudo-metal ion concept", INORGANIC CHEMISTRY, vol. 4, no. 11, November 1965 (1965-11-01), pages 1649 - 1655, XP002358132, ISSN: 0020-1669
QIN, YANG ET AL: "Luminescent Organoboron Quinolate Polymers", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 22, 9 June 2004 (2004-06-09), pages 7015 - 7018, XP002358129, ISSN: 0002-7863
MOEDER, CHARLES W. ET AL: "Kinetic analysis of the asymmetric amplification exhibited by B-chlorodiisopinocampheylborane", JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, vol. 17, no. 4, April 2004 (2004-04-01), pages 317 - 324, XP002358130, ISSN: 0894-3230
TABUCHI, HITOSHI ET AL: "Anticoccidial activity of some azacyclo organoborinates", HETEROCYCLES, vol. 60, no. 1, 2003, pages 177 - 182, XP001207975, ISSN: 0385-5414
GUO-ZHENG Y ET AL: "SINGLE SITE TRANSARYLATION OF 2,2'-DIMETALIZED-1,1'-BINAPHTHYL TO AMINOCLOROBORATES AND SYNTHESIS OF 2-BINAPHTHYL BORON COMPOUNDS", YOUJI HUAXUE / ORGANIC CHEMISTRY, SCIENCE PRESS, BEIJING, CN, vol. 16, no. 2, 1996, pages 139 - 144, XP002922569, ISSN: 0253-2786
BROWN, HERBERT C. ET AL: "Chiral synthesis via organoboranes. 35. Simple procedures for the efficient recycling of the terpenyl chiral auxiliaries and convenient isolation of the homoallylic alcohols in asymmetric allyl- and crotylboration of aldehydes", JOURNAL OF ORGANIC CHEMISTRY, vol. 57, no. 24, 1992, pages 6608 - 6614, XP002358131, ISSN: 0022-3263
FARFAN N ET AL: "THROUGH-BOND MODULATION ON N-B RING FORMATION SHOWN BY NMR AND X-RAY DIFFRACTION STUDIES OF BORATE DERIVATIVES OF PYRIDYL ALCOHOLS", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2, CHEMICAL SOCIETY. LETCHWORTH, GB, 1992, pages 527 - 532, XP002922571, ISSN: 1472-779X
ZIXING S ET AL: "SYNTHESIS OF AROMATIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES OF ASYMMETRIC DIARYLBORINIC ACIDS", WUHAN DAXUE XUEBAO - WUHAN UNIVERSITY JOURNAL, GAI KAN BIANJIBU, WUHAN,, CN, vol. 3, 1990, pages 67 - 71, XP002922573, ISSN: 1000-5374
BAILEY J ET AL: "BORON-CONTAINING ANTIBACTERIAL AGENTS: EFFECTS ON GROWTH AND MORPHOLOGY OF BACTERIA UNDER VARIOUS CULTURE CONDITIONS", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 17, no. 4, April 1980 (1980-04-01), pages 549 - 553, XP002922581, ISSN: 0066-4804
KOSTER, ROLAND ET AL: "Boron compounds, XXXIX. Alkenoxy(diorganyl)boranes substituted at the alkenoxy group from 2-methylacrolein and triorganylboranes", JUSTUS LIEBIGS ANNALEN DER CHEMIE, no. 6, 1976, pages 1116 - 1134, XP009058269, ISSN: 0075-4617
TOPORCER, LOUIS H. ET AL: "Preparation and properties of some tetracoordinate boron compounds. The pseudo-metal ion concept", INORGANIC CHEMISTRY, vol. 4, no. 11, November 1965 (1965-11-01), pages 1649 - 1655, XP002358132, ISSN: 0020-1669
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