Title:
ANTIBODIES AGAINST ACTIVATED FACTOR V
Document Type and Number:
WIPO Patent Application WO/2016/005564
Kind Code:
A3
Abstract:
The present invention relates to monoclonal antibodies or fragments thereof, that bind to activated Factor V (FVa), that display pro-coagulant effect and therapeutic uses in thereof.
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Inventors:
HOLMBERG HEIDI LINDGREEN (DK)
RØDER GUSTAV (DK)
BALLING KRISTOFFER WINTHER (DK)
RØDER GUSTAV (DK)
BALLING KRISTOFFER WINTHER (DK)
Application Number:
PCT/EP2015/065848
Publication Date:
April 07, 2016
Filing Date:
July 10, 2015
Export Citation:
Assignee:
NOVO NORDISK AS (DK)
International Classes:
A61K39/395; C07K16/36
Domestic Patent References:
| WO2007101106A2 | 2007-09-07 | |||
| WO2005111075A2 | 2005-11-24 | |||
| WO2008067056A2 | 2008-06-05 |
Foreign References:
| US5910576A | 1999-06-08 |
Other References:
SCHLACHTERMAN A ET AL: "Factor V Leiden improves in vivo hemostasis in murine hemophilia models", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, BLACKWELL PUBLISHING, OXFORD, GB, vol. 3, no. 12, 1 December 2005 (2005-12-01), pages 2730 - 2737, XP008130621, ISSN: 1538-7933, DOI: 10.1111/J.1538-7836.2005.01639.X
ANNETTE VON DRYGALSKI ET AL: "Superior in Vivo Hemostatic Properties of an Engineered Factor Va Variant for Hemophilia Mice", vol. 120, no. 21, 1 November 2012 (2012-11-01), XP002722413, ISSN: 0006-4971, Retrieved from the Internet [retrieved on 20150917]
W B FOSTER ET AL: "Monoclonal Antibodies Selective for Activated Factor V", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 258, no. 9, 10 March 1983 (1983-03-10), pages 5606 - 5613, XP055177012, Retrieved from the Internet [retrieved on 20150316]
SUHNG WOOK KIM ET AL: "Identification of Functionally Important Amino Acid Residues within the C2-Domain of Human Factor V Using Alanine-Scanning Mutagenesis +", BIOCHEMISTRY, vol. 39, no. 8, 1 February 2000 (2000-02-01), pages 1951 - 1958, XP055171137, ISSN: 0006-2960, DOI: 10.1021/bi992256r
KENNETH SEGERS ET AL: "Coagulation factor V and thrombophilia: Background and mechanisms", THROMBOSIS AND HAEMOSTASIS, vol. 98, no. 3, 17 October 2007 (2007-10-17), pages 530 - 42, XP055175994, ISSN: 0340-6245, DOI: 10.1160/TH07-02-0150
KALAFATIS M ET AL: "Contribution of the heavy and light chains of factor Va to the interaction with factor Xa", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 33, no. 21, 31 May 1994 (1994-05-31), pages 6538 - 6545, XP002590638, ISSN: 0006-2960
ANNETTE VON DRYGALSKI ET AL: "Superior in Vivo Hemostatic Properties of an Engineered Factor Va Variant for Hemophilia Mice", vol. 120, no. 21, 1 November 2012 (2012-11-01), XP002722413, ISSN: 0006-4971, Retrieved from the Internet
W B FOSTER ET AL: "Monoclonal Antibodies Selective for Activated Factor V", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 258, no. 9, 10 March 1983 (1983-03-10), pages 5606 - 5613, XP055177012, Retrieved from the Internet
SUHNG WOOK KIM ET AL: "Identification of Functionally Important Amino Acid Residues within the C2-Domain of Human Factor V Using Alanine-Scanning Mutagenesis +", BIOCHEMISTRY, vol. 39, no. 8, 1 February 2000 (2000-02-01), pages 1951 - 1958, XP055171137, ISSN: 0006-2960, DOI: 10.1021/bi992256r
KENNETH SEGERS ET AL: "Coagulation factor V and thrombophilia: Background and mechanisms", THROMBOSIS AND HAEMOSTASIS, vol. 98, no. 3, 17 October 2007 (2007-10-17), pages 530 - 42, XP055175994, ISSN: 0340-6245, DOI: 10.1160/TH07-02-0150
KALAFATIS M ET AL: "Contribution of the heavy and light chains of factor Va to the interaction with factor Xa", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 33, no. 21, 31 May 1994 (1994-05-31), pages 6538 - 6545, XP002590638, ISSN: 0006-2960
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