Title:
ANTIBODIES AGAINST CASPASE-8, THEIR PREPARATION AND USE
Document Type and Number:
WIPO Patent Application WO2003020767
Kind Code:
A3
Abstract:
The invention relates to antibodies to a specific region in caspase-8, and to their use.
Inventors:
WALLACH DAVID (IL)
GONCHAROV TANYA (IL)
KOLUMAM GANESH (US)
GONCHAROV TANYA (IL)
KOLUMAM GANESH (US)
Application Number:
PCT/IL2002/000734
Publication Date:
October 02, 2003
Filing Date:
September 04, 2002
Export Citation:
Assignee:
YEDA RES & DEV (IL)
WALLACH DAVID (IL)
GONCHAROV TANYA (IL)
KOLUMAM GANESH (US)
WALLACH DAVID (IL)
GONCHAROV TANYA (IL)
KOLUMAM GANESH (US)
International Classes:
C12N15/09; A61K39/395; A61P7/00; A61P37/02; C07K1/30; C07K16/40; C07K16/46; C12N15/02; C12P21/08; (IPC1-7): C07K16/40; C07K14/47; C12N9/64; G01N33/53
Domestic Patent References:
| WO2000077201A1 | 2000-12-21 |
Other References:
MEDEMA JAN PAUL ET AL: "Bcl-xL acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 6, 6 February 1998 (1998-02-06), pages 3388 - 3393, XP002229994, ISSN: 0021-9258
"Anti-caspase 8 (GD-13); Product number C2976", SIGMA PRODUCT INFORMATION, September 1999 (1999-09-01), XP002229995, Retrieved from the Internet [retrieved on 20030124]
"Caspase-8 (1C12) Monoclonal Antibody", CELL SIGNALING PRODUCT SPECIFICATION, 1999, XP002229996, Retrieved from the Internet [retrieved on 20030124]
RODIER F ET AL: "Polyomavirus large T-antigen protects mouse cells from Fas-, TNF-alpha- and taxol-induced apoptosis.", ONCOGENE, vol. 19, no. 54, 2000, pages 6261 - 6270, XP008012999, ISSN: 0950-9232
BOLDIN M P ET AL: "INVOLVEMENT OF MACH, A NOVEL MORT1/FADD-INTERACTING PROTEASE, IN FAS/APO-1- AND TNF RECEPTOR-INDUCED CELL DEATH", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 85, no. 6, 14 June 1996 (1996-06-14), pages 803 - 815, XP002037501, ISSN: 0092-8674
NIIKURA YUICHI ET AL: "Monitoring of caspase-8/FLICE processing and activation upon Fas stimulation with novel antibodies directed against a cleavage site for caspase-8 and its substrate, FLICE-like inhibitory protein (FLIP).", JOURNAL OF BIOCHEMISTRY (TOKYO), vol. 132, no. 1, July 2002 (2002-07-01), pages 53 - 62, XP001109528, ISSN: 0021-924X
"Anti-caspase 8 (GD-13); Product number C2976", SIGMA PRODUCT INFORMATION, September 1999 (1999-09-01), XP002229995, Retrieved from the Internet
"Caspase-8 (1C12) Monoclonal Antibody", CELL SIGNALING PRODUCT SPECIFICATION, 1999, XP002229996, Retrieved from the Internet
RODIER F ET AL: "Polyomavirus large T-antigen protects mouse cells from Fas-, TNF-alpha- and taxol-induced apoptosis.", ONCOGENE, vol. 19, no. 54, 2000, pages 6261 - 6270, XP008012999, ISSN: 0950-9232
BOLDIN M P ET AL: "INVOLVEMENT OF MACH, A NOVEL MORT1/FADD-INTERACTING PROTEASE, IN FAS/APO-1- AND TNF RECEPTOR-INDUCED CELL DEATH", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 85, no. 6, 14 June 1996 (1996-06-14), pages 803 - 815, XP002037501, ISSN: 0092-8674
NIIKURA YUICHI ET AL: "Monitoring of caspase-8/FLICE processing and activation upon Fas stimulation with novel antibodies directed against a cleavage site for caspase-8 and its substrate, FLICE-like inhibitory protein (FLIP).", JOURNAL OF BIOCHEMISTRY (TOKYO), vol. 132, no. 1, July 2002 (2002-07-01), pages 53 - 62, XP001109528, ISSN: 0021-924X
Download PDF: