Title:
ANTIBODIES AGAINST CHEMOKINES, METHOD FOR IDENTIFYING SAID ANTIBODIES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/213911
Kind Code:
A3
Abstract:
The present disclosure provides antibodies against chemokines, in particular to auto-antibodies against chemokines, nucleic acids encoding such antibodies and compositions comprising such antibodies. The present disclosure also provides a method for identifying (auto-)antibodies against chemokines, antibodies identified by said method and to the use of antibodies against chemokines as biomarkers, and for the treatment and diagnosis of diseases, such as COVID-19.
Inventors:
ROBBIANI DAVIDE (CH)
UGUCCIONI MARIAGRAZIA (CH)
CAVALLI ANDREA (CH)
MURI JONATHAN (CH)
CECCHINATO VALENTINA (IT)
UGUCCIONI MARIAGRAZIA (CH)
CAVALLI ANDREA (CH)
MURI JONATHAN (CH)
CECCHINATO VALENTINA (IT)
Application Number:
PCT/EP2023/061726
Publication Date:
January 18, 2024
Filing Date:
May 03, 2023
Export Citation:
Assignee:
INST RES BIOMEDICINE (CH)
International Classes:
C07K16/24; G01N33/564; G01N33/569
Domestic Patent References:
| WO2010020669A1 | 2010-02-25 | |||
| WO2004016769A2 | 2004-02-26 | |||
| WO2004024088A2 | 2004-03-25 | |||
| WO2014003744A1 | 2014-01-03 |
Foreign References:
| EP3546481A2 | 2019-10-02 | |||
| US20060233748A1 | 2006-10-19 | |||
| EP2921858A1 | 2015-09-23 | |||
| CN112285360A | 2021-01-29 |
Other References:
WANG ERIC Y ET AL: "Diverse functional autoantibodies in patients with COVID-19", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 595, no. 7866, 19 May 2021 (2021-05-19), pages 283 - 288, XP037500116, ISSN: 0028-0836, [retrieved on 20210519], DOI: 10.1038/S41586-021-03631-Y
WANG ERIC Y. ET AL: "REAP: A platform to identify autoantibodies that target the human exoproteome", BIORXIV, 12 February 2021 (2021-02-12), pages 1 - 44, XP055859067, Retrieved from the Internet [retrieved on 20211109], DOI: 10.1101/2021.02.11.430703
ABRAHAM MICHAL ET AL: "Natural and induced immunization against CCL20 ameliorate experimental autoimmune encephalitis and may confer protection against multiple sclerosis", CLINICAL IMMUNOLOGY, vol. 183, 2017, pages 316 - 324, XP085256948, ISSN: 1521-6616, DOI: 10.1016/J.CLIM.2017.09.018
RECKE ANDREAS ET AL: "Autoantibodies in Serum of Systemic Scleroderma Patients: Peptide-Based Epitope Mapping Indicates Increased Binding to Cytoplasmic Domains of CXCR3", vol. 9, 22 March 2018 (2018-03-22), XP093003753, Retrieved from the Internet DOI: 10.3389/fimmu.2018.00428
ZHAO XINYAN ET AL: "CCL9 Is Secreted by the Follicle-Associated Epithelium and Recruits Dome Region Peyer's Patch CD11b + Dendritic Cells", vol. 171, no. 6, 5 September 2003 (2003-09-05), US, pages 2797 - 2803, XP093003858, ISSN: 0022-1767, Retrieved from the Internet DOI: 10.4049/jimmunol.171.6.2797
GLASS WILLIAM G. ET AL: "Antibody Targeting of the CC Chemokine Ligand 5 Results in Diminished Leukocyte Infiltration into the Central Nervous System and Reduced Neurologic Disease in a Viral Model of Multiple Sclerosis", vol. 172, no. 7, 19 March 2004 (2004-03-19), US, pages 4018 - 4025, XP093003874, ISSN: 0022-1767, Retrieved from the Internet DOI: 10.4049/jimmunol.172.7.4018
OBMOLOVA GALINA ET AL: "Structural basis for high selectivity of anti-CCL2 neutralizing antibody CNTO 888", vol. 51, no. 2, 1 June 2012 (2012-06-01), GB, pages 227 - 233, XP093003889, ISSN: 0161-5890, Retrieved from the Internet DOI: 10.1016/j.molimm.2012.03.022
KARIN NATHAN: "Autoantibodies to Chemokines and Cytokines Participate in the Regulation of Cancer and Autoimmunity", vol. 9, 29 March 2018 (2018-03-29), XP093004481, Retrieved from the Internet DOI: 10.3389/fimmu.2018.00623
PETERSEN ANDERS Ø ET AL: "Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 148, no. 3, 2 April 2021 (2021-04-02), pages 876 - 888, XP086762441, ISSN: 0091-6749, [retrieved on 20210402], DOI: 10.1016/J.JACI.2021.03.025
RUCKES T ET AL: "Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 98, no. 4, 15 August 2001 (2001-08-15), pages 1150 - 1159, XP002264850, ISSN: 0006-4971, DOI: 10.1182/BLOOD.V98.4.1150
ANONYMOUS: "Human CCL1/I-309/TCA-3 Antibody Polyclonal Goat IgG-AF272", R&D SYSTEMS, 8 February 2010 (2010-02-08), pages 1 - 2, XP093097567, Retrieved from the Internet [retrieved on 20231102]
SINO BIOLOGICALS Q C: "Human I-309 / CCL1 / TCA-3 Protein (Fc Tag)", SINO BIOLOGICALS, 19 January 2011 (2011-01-19), pages 1 - 1, XP093097266, Retrieved from the Internet [retrieved on 20231102]
ANONYMOUS SWISS: "h-I-309 (AF647 ) CCL1", ALMAC, 30 December 2021 (2021-12-30), pages 1 - 1, XP093097268, Retrieved from the Internet
WANG ERIC Y. ET AL: "REAP: A platform to identify autoantibodies that target the human exoproteome", BIORXIV, 12 February 2021 (2021-02-12), pages 1 - 44, XP055859067, Retrieved from the Internet
ABRAHAM MICHAL ET AL: "Natural and induced immunization against CCL20 ameliorate experimental autoimmune encephalitis and may confer protection against multiple sclerosis", CLINICAL IMMUNOLOGY, vol. 183, 2017, pages 316 - 324, XP085256948, ISSN: 1521-6616, DOI: 10.1016/J.CLIM.2017.09.018
RECKE ANDREAS ET AL: "Autoantibodies in Serum of Systemic Scleroderma Patients: Peptide-Based Epitope Mapping Indicates Increased Binding to Cytoplasmic Domains of CXCR3", vol. 9, 22 March 2018 (2018-03-22), XP093003753, Retrieved from the Internet
ZHAO XINYAN ET AL: "CCL9 Is Secreted by the Follicle-Associated Epithelium and Recruits Dome Region Peyer's Patch CD11b + Dendritic Cells", vol. 171, no. 6, 5 September 2003 (2003-09-05), US, pages 2797 - 2803, XP093003858, ISSN: 0022-1767, Retrieved from the Internet
GLASS WILLIAM G. ET AL: "Antibody Targeting of the CC Chemokine Ligand 5 Results in Diminished Leukocyte Infiltration into the Central Nervous System and Reduced Neurologic Disease in a Viral Model of Multiple Sclerosis", vol. 172, no. 7, 19 March 2004 (2004-03-19), US, pages 4018 - 4025, XP093003874, ISSN: 0022-1767, Retrieved from the Internet
OBMOLOVA GALINA ET AL: "Structural basis for high selectivity of anti-CCL2 neutralizing antibody CNTO 888", vol. 51, no. 2, 1 June 2012 (2012-06-01), GB, pages 227 - 233, XP093003889, ISSN: 0161-5890, Retrieved from the Internet
KARIN NATHAN: "Autoantibodies to Chemokines and Cytokines Participate in the Regulation of Cancer and Autoimmunity", vol. 9, 29 March 2018 (2018-03-29), XP093004481, Retrieved from the Internet
PETERSEN ANDERS Ø ET AL: "Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 148, no. 3, 2 April 2021 (2021-04-02), pages 876 - 888, XP086762441, ISSN: 0091-6749, [retrieved on 20210402], DOI: 10.1016/J.JACI.2021.03.025
RUCKES T ET AL: "Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 98, no. 4, 15 August 2001 (2001-08-15), pages 1150 - 1159, XP002264850, ISSN: 0006-4971, DOI: 10.1182/BLOOD.V98.4.1150
ANONYMOUS: "Human CCL1/I-309/TCA-3 Antibody Polyclonal Goat IgG-AF272", R&D SYSTEMS, 8 February 2010 (2010-02-08), pages 1 - 2, XP093097567, Retrieved from the Internet
SINO BIOLOGICALS Q C: "Human I-309 / CCL1 / TCA-3 Protein (Fc Tag)", SINO BIOLOGICALS, 19 January 2011 (2011-01-19), pages 1 - 1, XP093097266, Retrieved from the Internet
ANONYMOUS SWISS: "h-I-309 (AF647 ) CCL1", ALMAC, 30 December 2021 (2021-12-30), pages 1 - 1, XP093097268, Retrieved from the Internet
Attorney, Agent or Firm:
GRAF VON STOSCH PATENTANWALTSGESELLSCHAFT MBH et al. (DE)
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