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Title:
ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/187835
Kind Code:
A3
Abstract:
Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid- inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

Inventors:
WANG, Changyu (32264 Ashley Way, Union City, CA, 94587, US)
LONBERG, Nils (700 Bay Road, Redwood City, CA, 94063, US)
KORMAN, Alan J. (700 Bay Road, Redwood city, CA, 94063, US)
SELBY, Mark J. (700 Bay Road, Redwood City, CA, 94063, US)
SRINIVASAN, Mohan (700 Bay Road, Redwood City, CA, 94063, US)
HENNING, Karla (700 Bay Road, Redwood City, CA, 94063, US)
HAN, Michelle, Minhua (700 Bay Road, Redwood City, CA, 94063, US)
CHEN, Guodong (Route 206 & Province Line Rd, Princeton, NJ, 08543, US)
HUANG, Richard (Route 206 & Province Line Rd, Princeton, NJ, 08543, US)
CHAKRABORTY, Indrani (700 Bay Road, Redwood City, CA, 94063, US)
HUANG, Haichun (700 Bay Road, Redwood City, California, 94063, US)
WONG, Susan (700 Bay Road, Redwood City, California, 94063, US)
LI, Huiming (100 Beaver Street, Waltham, MA, 02453, US)
Application Number:
US2015/033991
Publication Date:
January 28, 2016
Filing Date:
June 03, 2015
Export Citation:
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Assignee:
BRISTOL-MYERS SQUIBB COMPANY (Route 206 & Province Line Road, Princeton, NJ, 08543, US)
International Classes:
A61P35/00; A61K39/00; C07K16/28
Domestic Patent References:
WO2011028683A12011-03-10
WO2005007190A12005-01-27
WO2013039954A12013-03-21
Foreign References:
US20140065152A12014-03-06
EP2481752A12012-08-01
Other References:
BULLIARD YANNICK ET AL: "Activating Fc gamma receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 210, no. 9, 26 August 2013 (2013-08-26), pages 1685 - 1693, XP009176020, ISSN: 0022-1007
ANN L. WHITE ET AL: "Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies", CANCER CELL, vol. 27, no. 1, 1 January 2015 (2015-01-01), pages 138 - 148, XP055193819, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2014.11.001
Attorney, Agent or Firm:
REMILLARD, Jane, E. et al. (Nelson Mullins Riley & Scarborough LLP, One Post Office SquareBoston, MA, 02109-2127, US)
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