Title:
ANTIBODIES AGAINST TIM3 AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/013818
Kind Code:
A3
Abstract:
Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
Inventors:
SCHEBYE XIAO MIN (US)
SELBY MARK J (US)
HAN MICHELLE MINHUA (US)
BEE CHRISTINE (US)
DENG ANDY X (US)
CHUNTHARAPAI ANAN (US)
DEVAUX BRIGITTE (US)
LI HUIMING (US)
SHEPPARD PAUL O (US)
KORMAN ALAN J (US)
ARDOUREL DANIEL F (US)
DEYANOVA EKATERINA (US)
HUANG RICHARD (US)
CHEN GUODONG (US)
KUHNE MICHELLE (US)
TRUONG HONG AN (US)
SELBY MARK J (US)
HAN MICHELLE MINHUA (US)
BEE CHRISTINE (US)
DENG ANDY X (US)
CHUNTHARAPAI ANAN (US)
DEVAUX BRIGITTE (US)
LI HUIMING (US)
SHEPPARD PAUL O (US)
KORMAN ALAN J (US)
ARDOUREL DANIEL F (US)
DEYANOVA EKATERINA (US)
HUANG RICHARD (US)
CHEN GUODONG (US)
KUHNE MICHELLE (US)
TRUONG HONG AN (US)
Application Number:
PCT/US2017/041946
Publication Date:
February 22, 2018
Filing Date:
July 13, 2017
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
International Classes:
C07K16/28
Domestic Patent References:
| WO2013006490A2 | 2013-01-10 | |||
| WO2016068802A1 | 2016-05-06 | |||
| WO2016071448A1 | 2016-05-12 |
Foreign References:
| US20120189617A1 | 2012-07-26 | |||
| US20150218274A1 | 2015-08-06 |
Other References:
YOSHIKANE KIKUSHIGE ET AL: "TIM-3 as a novel therapeutic target for eradicating acute myelogenous leukemia stem cells", INTERNATIONAL JOURNAL OF HEMATOLOGY, vol. 98, no. 6, 18 September 2013 (2013-09-18), pages 627 - 633, XP055181432, ISSN: 0925-5710, DOI: 10.1007/s12185-013-1433-6
ROBERT L. FERRIS ET AL: "Too Much of a Good Thing? Tim-3 and TCR Signaling in T Cell Exhaustion", THE JOURNAL OF IMMUNOLOGY, vol. 193, no. 4, 1 August 2014 (2014-08-01), US, pages 1525 - 1530, XP055327897, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1400557
ROBERT L. FERRIS ET AL: "Too Much of a Good Thing? Tim-3 and TCR Signaling in T Cell Exhaustion", THE JOURNAL OF IMMUNOLOGY, vol. 193, no. 4, 1 August 2014 (2014-08-01), US, pages 1525 - 1530, XP055327897, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1400557
Attorney, Agent or Firm:
KIM, Ji-Eun et al. (US)
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