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Title:
ANTIBODIES AND ASSAYS FOR DETECTION OF FOLATE RECEPTOR 1
Document Type and Number:
WIPO Patent Application WO/2015/031815
Kind Code:
A3
Abstract:
The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.

Inventors:
AB OLGA (US)
TAVARES DANIEL (US)
SETIADY JULIANTO (US)
LADD SHARRON (US)
CARRIGAN CHRISTINA N (US)
RUI LINGYUN (US)
Application Number:
PCT/US2014/053512
Publication Date:
May 07, 2015
Filing Date:
August 29, 2014
Export Citation:
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Assignee:
IMMUNOGEN INC (US)
International Classes:
A61K39/395; C07K16/28
Domestic Patent References:
WO2008103473A12008-08-28
WO2011042548A12011-04-14
WO2007020965A12007-02-22
Foreign References:
US20120009181A12012-01-12
US20070048315A12007-03-01
US20090156788A12009-06-18
US20110002942A12011-01-06
US20130039916A12013-02-14
US20120282637A12012-11-08
US20080171014A12008-07-17
US20110256127A12011-10-20
US20110038867A12011-02-17
US7465449B22008-12-16
US8153126B22012-04-10
US20120251532A12012-10-04
US20090087478A12009-04-02
US20040031072A12004-02-12
US20070071675A12007-03-29
US7915368B22011-03-29
US20070253950A12007-11-01
US20070286858A12007-12-13
Other References:
ROBERTS ET AL.: "Role of individual N-linked glycosylatlon sites in the function and intracellular transport of the human alpha folate receptor.", ARCH BIOCHEM BLOPHYS, vol. 351, no. 2, 15 March 1998 (1998-03-15), pages 227 - 235, XP055324373
DATABASE UNIPROTKB [online] 28 November 2012 (2012-11-28), "SUBNAME: FULL=UNCHARACTERIZED PROTEIN {ECO:0000313|EMBL:EGU32542.1};", XP055324408, retrieved from UNIPROT uniprot Database accession no. F9RS38
DATABASE UNTPROTKB [online] 28 November 2012 (2012-11-28), "SUBNAME: FULL=OXIDOREDUCTASE, NAD-BINDING DOMAIN PROTEIN{ECO:0000313|EMBL:EHM72633.1};", XP055324474, retrieved from UNIPROT urdprot Database accession no. H0DED6
DATABASE UNIPROTKB/TREMBL [online] 24 July 2013 (2013-07-24), "SUBNAME: FULL=UNCHARACTERIZED PROTEIN {ECO:0000313|EMBL:CCY31841.1};", XP055324528, retrieved from UNIPROT uniprot Database accession no. R5I4W9
Attorney, Agent or Firm:
STEFFE, Eric, K. et al. (Kessler Goldstein & Fox P.L.L.C.,1100 New York Ave, N.W, Washington DC, US)
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