Title:
ANTIBODIES BINDING C5 AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/012606
Kind Code:
A1
Abstract:
An isolated monoclonal antibody that specifically binds human C5, or the antigen-binding portion thereof. A nucleic acid molecule encoding the antibody or the antigen-binding portion thereof, an expression vector, a host cell and a method for expressing the antibody or the antigen-binding portion thereof are also provided. Further provided are a bispecific molecule, an immunoconjugate, a chimeric antigen receptor, an oncolytic virus and a pharmaceutical composition comprising the antibody or the antigen-binding portion thereof, as well as a treatment method using an anti-C5 antibody or the antigen-binding portion thereof.
Inventors:
CHEN MINGJIU (CN)
XIA SHUKAI (CN)
XIA SHUKAI (CN)
Application Number:
PCT/CN2021/106391
Publication Date:
January 20, 2022
Filing Date:
July 15, 2021
Export Citation:
Assignee:
BIOSION INC (CN)
International Classes:
A61K39/395; C07K16/00; C07K16/18; C12N15/09
Domestic Patent References:
| WO1995029697A1 | 1995-11-09 | |||
| WO2010015608A1 | 2010-02-11 |
Foreign References:
| EP0411306A1 | 1991-02-06 | |||
| CN101443050A | 2009-05-27 | |||
| CN110603054A | 2019-12-20 |
Other References:
CHEN CHEN, LV RUO-YUN, WEI JING-SHUANG: "Role of C5a in inflammatory reaction and development of anti-C5a antibody drugs", CHINESE JOURNAL OF BIOLOGICALS, CHINESE PREVENTIVE MEDICINE ASSOCIATION, CHINA, vol. 28, no. 5, 31 May 2015 (2015-05-31), China , XP055889587, ISSN: 1004-5503
WANG， X.W. ET AL.: "Immunoglobulin VH Gene Expression in Human Aging", CLINICAL IMMUNOLOGY, vol. 93, no. 2, 30 November 1999 (1999-11-30), XP002971864, DOI: 10.1006/clim.1999.4781
See also references of EP 4181958A4
WANG， X.W. ET AL.: "Immunoglobulin VH Gene Expression in Human Aging", CLINICAL IMMUNOLOGY, vol. 93, no. 2, 30 November 1999 (1999-11-30), XP002971864, DOI: 10.1006/clim.1999.4781
See also references of EP 4181958A4
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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