Title:
ANTIBODIES BINDING CTLA-4 AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/120232
Kind Code:
A1
Abstract:
Disclosed are isolated monoclonal antibodies, comprising a CD152-binding domain, wherein the antibodies bind specifically to human CD152. Methods of making and using the antibodies to treat diseases including cancers and autoimmune diseases are also provided.
Inventors:
GAN XIN (CN)
HE YUN (CN)
SHEN YUQIANG (CN)
ZHAO JIUQIAO (US)
RONG YIPING (CN)
GROSVELD FRANK (NL)
DRABEK DUBRAVKA (NL)
VAN HAPEREN MARINUS (RIEN) (NL)
JANSSENS RICK (NL)
HE YUN (CN)
SHEN YUQIANG (CN)
ZHAO JIUQIAO (US)
RONG YIPING (CN)
GROSVELD FRANK (NL)
DRABEK DUBRAVKA (NL)
VAN HAPEREN MARINUS (RIEN) (NL)
JANSSENS RICK (NL)
Application Number:
PCT/CN2018/122190
Publication Date:
June 27, 2019
Filing Date:
December 19, 2018
Export Citation:
Assignee:
HARBOUR BIOMED SHANGHAI CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00
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| WO2017198212A1 | 2017-11-23 | |||
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NEUMANN ET AL., EMBO J., vol. 1, 1982, pages 841 - 845
HAWLEY-NELSON ET AL., FOCUS, vol. 15, 1993, pages 80
CHASIN ET AL., SOM. CELL. MOLEC. GENET., vol. 12, 1986, pages 555
GATIGNOL ET AL., MOL. GEN. GENET., vol. 207, 1987, pages 342
SINKAR ET AL., J. BIOSCI. (BANGALORE, vol. 11, 1987, pages 47 - 58
BONNING ET AL., J. GEN. VIROL., vol. 75, 1994, pages 1551 - 1556
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GLEESON ET AL., J. GEN. MICROBIOL., vol. 132, 1986, pages 3459 - 3465
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HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
PANTOLIANO ET AL., BIOCHEM., vol. 30, 1991, pages 10117 - 10125
"Affinity Chromatography: Principles & Methods", 1988, PHARMACIA LKB BIOTECHNOLOGY
SCOPES: "Protein Purification: Principles and Practice", 1994, SPRINGER-VERLAG
LONBERGHUSZAR, INTERNAL REV. IMMUNOL., vol. 13, 1995, pages 65 - 93
HARDINGLONBERG, ANN. N.Y. ACAD. SCI., vol. 764, 1995, pages 536 - 546
"Uniprot", Database accession no. P33681
See also references of EP 3710484A4
DYCKMILLS, EUR. J. IMMUNOL., vol. 47, no. 5, 2017, pages 765 - 779
BRUNET ET AL., NATURE, vol. 328, 1987, pages 267 - 270
WALUNAS ET AL., IMMUNITY, vol. 1, 1994, pages 405 - 413
VAN DER MERWE ET AL., J EXP MED., vol. 185, 1997, pages 393 - 403
ALEGRE ET AL., NAT REV IMMUNOL, vol. 1, 2001, pages 220 - 228
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 97
HONGO ET AL., HYBRIDOMA, vol. 14, no. 3, 1995, pages 253 - 260
VERHOEYEN ET AL., SCIENCE, vol. 242, 1988, pages 1534 - 1536
CORSAROPEARSON, SOMATIC CELL GENETICS, vol. 7, 1981, pages 603 - 681
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
MARKS ET AL., J. MOL. BIOL., vol. 222, 1992, pages 581 - 597
SIDHU ET AL., J. MOL. BIOL., vol. 340, no. 5, 2004, pages 1073 - 1093
FELLOUSE, PROC. NATL. ACAD. SCI. USA, vol. 101, no. 34, 2004, pages 12467 - 12472
LEE ET AL., J. IMMUNOL. METHODS, vol. 284, no. 1-2, 2004, pages 119 - 132
JAKOBOVITS ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, no. 12, 1993, pages 5873 - 5877
JAKOBOVITS ET AL., NATURE, vol. 362, 1993, pages 255 - 258
BRUGGEMANN ET AL., YEAR IN IMMUNOL., vol. 7, 1993, pages 33
MARKS ET AL., BIOLTECHNOLOGY, vol. 10, 1992, pages 779 - 783
LONBERG ET AL., NATURE, vol. 368, 1994, pages 812 - 813
FISHWILD ET AL., NATURE BIOTECHNOL., vol. 14, 1996, pages 826 - 851
LONBERGHUSZAR, INTERN. REV. IMMUNOL., vol. 13, 1995, pages 65 - 93
FLATMAN ET AL., J. CHROMATOGR. B, vol. 848, 2007, pages 79 - 87
SCATCHARD ET AL., ANN. N.Y. ACAD. SCI., vol. 51, 1949, pages 660
LEHNINGER: "Biochemistry", 1975, WORTH PUBLISHERS, INC, pages: 71 - 77
DROCOURT ET AL., NUCL. ACIDS RES., vol. 18, 1990, pages 4009
BROCHET, X ET AL., NUCL. ACIDS RES., vol. 36, 2008, pages W503 - 508
WARD ET AL., THERAP. IMMUNOL., vol. 2, 1995, pages 77 - 94
TEMPEST ET AL., BIOLTECHNOL, vol. 9, 1991, pages 266 - 271
JONES ET AL., NATURE, vol. 321, 1986, pages 522
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 337
QUEEN ET AL., PROC NATL ACAD SCI USA, vol. 86, 1989, pages 10029 - 10033
CO ET AL., PROC NATL ACAD SCI USA, vol. 88, 1991, pages 2869 - 2873
CO ET AL., J IMMUNOL, vol. 148, 1992, pages 1149 - 1154
MARK ET AL.: "Cellular adhesion: molecular definition to therapeutic potential", 1994, PLENUM PRESS, article "Derivation of therapeutically active humanized and veneered anti-CD18 antibodies", pages: 291 - 312
RAVETCH ET AL., ANNU. REV. IMMUNOL., vol. 9, 1991, pages 457 - 92
BATZER ET AL., NUCLEIC ACID RES., vol. 19, 1991, pages 5081
OHTSUKA ET AL., J. BIOL. CHEM., vol. 260, 1985, pages 2605 - 2608
ROSSOLINI ET AL., MOL. CELL. PROBES, vol. 8, 1994, pages 91 - 98
BRUMMELL ET AL., BIOCHEM, vol. 32, 1993, pages 1180 - 8
WILDT ET AL., PROT. ENG., vol. 10, 1997, pages 835 - 41
KOMISSAROV ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 26864 - 26870
HALL ET AL., J. IMMUNOL., vol. 149, 1992, pages 1605 - 12
KELLEYO'CONNELL, BIOCHEM., vol. 32, 1993, pages 6862 - 35
ADIB-CONQUY ET AL., INT. IMMUNOL., vol. 10, 1998, pages 341 - 6
BEERS ET AL., CLIN. CAN. RES., vol. 6, 2000, pages 2835 - 43
"Remington: The Science and Practice of Pharmacy", 2003, LIPPINCOTT WILLIAMS & WILKINS
BLOEMAN ET AL., FEBS LETT., vol. 357, 1995, pages 140
WIGLER ET AL., CELL, vol. 14, 1978, pages 725
V. V. RANADE, J. CLIN.PHARMACOL, vol. 29, 1989, pages 685
UMEZAWA ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 153, 1988, pages 1038
M. OWAIS ET AL., ANTIMICROB. AGENTS CHEMOTHER, vol. 39, 1995, pages 180
BRISCOE ET AL., AM. J. PHYSIOL., vol. 1233, 1995, pages 134
SCHREIER ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 9090
KEINANENLAUKKANEN, FEBS LETT., vol. 346, 1994, pages 123
KILLIONFIDLER, IMMUNOMETHODS, vol. 4, 1994, pages 273
LJUNGGRENMALMBERG, NATURE REV. IMMUNOL., vol. 7, 2007, pages 329 - 339
BOYTONALTMANN, CLIN. EXP. IMMUNOL., vol. 149, 2007, pages 1 - 8
THERASSE ET AL., J. NATL. CANCER INST., vol. 92, 2000, pages 205 - 216
"Guidance for Industry: Clinical Trial Endpoints for the Approval of Cancer Drugs and Biologics", April 2005, CENTER FOR DRUG EVALUATION AND RESEARCH
SAMBROOKRUSSELL: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1999, JOHN WILEY & SONS
GRAHAMVAN DER EB, VIROLOGY, vol. 52, 1973, pages 456
NEUMANN ET AL., EMBO J., vol. 1, 1982, pages 841 - 845
HAWLEY-NELSON ET AL., FOCUS, vol. 15, 1993, pages 80
CHASIN ET AL., SOM. CELL. MOLEC. GENET., vol. 12, 1986, pages 555
GATIGNOL ET AL., MOL. GEN. GENET., vol. 207, 1987, pages 342
SINKAR ET AL., J. BIOSCI. (BANGALORE, vol. 11, 1987, pages 47 - 58
BONNING ET AL., J. GEN. VIROL., vol. 75, 1994, pages 1551 - 1556
CHAZENBALKRAPOPORT, J. BIOL. CHEM., vol. 270, 1995, pages 1543 - 1549
LUCKOW ET AL., J. VIROL., vol. 67, 1993, pages 4566 - 4579
HILL-PERKINSPOSSEE, J. GEN. VIROL., vol. 71, 1990, pages 971 - 976
GLEESON ET AL., J. GEN. MICROBIOL., vol. 132, 1986, pages 3459 - 3465
RAYMOND ET AL., YEAST, vol. 14, 1998, pages 11 - 23
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
PANTOLIANO ET AL., BIOCHEM., vol. 30, 1991, pages 10117 - 10125
"Affinity Chromatography: Principles & Methods", 1988, PHARMACIA LKB BIOTECHNOLOGY
SCOPES: "Protein Purification: Principles and Practice", 1994, SPRINGER-VERLAG
LONBERGHUSZAR, INTERNAL REV. IMMUNOL., vol. 13, 1995, pages 65 - 93
HARDINGLONBERG, ANN. N.Y. ACAD. SCI., vol. 764, 1995, pages 536 - 546
"Uniprot", Database accession no. P33681
See also references of EP 3710484A4
Attorney, Agent or Firm:
SHENZHEN SERMON PATENT FIRM (CN)
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