Title:
ANTIBODIES COMPRISING SEQUENCES FROM CAMELIDAE TO HIGHLY CONSERVED TARGETS
Document Type and Number:
WIPO Patent Application WO/2014/013075
Kind Code:
A3
Abstract:
The present invention is concerned with antigen binding polypeptides, and in particular conventional antibodies derived from camelid species, that specifically bind to target antigens that are either self-antigens or highly conserved antigens. The present invention also relates to anti-idiotype antigen binding peptides which bind to a target antigen comprising the variable region of an antibody obtained from a species within the family Camelidae.
Inventors:
DE HAARD JOHANNES JOSEPH WILHELMUS (NL)
BLANCHETOT CHRISTOPHE FREDERIC JEROME (NL)
BLANCHETOT CHRISTOPHE FREDERIC JEROME (NL)
Application Number:
PCT/EP2013/065350
Publication Date:
December 18, 2014
Filing Date:
July 19, 2013
Export Citation:
Assignee:
ARGEN X BV (NL)
International Classes:
B01D15/18; C07K16/00; B01D15/38; C07K16/28; C07K16/42; G01N33/68
Domestic Patent References:
| WO2012022814A1 | 2012-02-23 | |||
| WO2010001251A2 | 2010-01-07 |
Other References:
ANNA HRABOVSKA ET AL: "A Novel System for the Efficient Generation of Antibodies Following Immunization of Unique Knockout Mouse Strains", PLOS ONE, vol. 5, no. 9, 23 September 2010 (2010-09-23), pages e12892, XP055131783, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0012892
HONGZHE ZHOU ET AL: "Generation of Monoclonal Antibodies against Highly Conserved Antigens", PLOS ONE, vol. 4, no. 6, 30 June 2009 (2009-06-30), pages e6087, XP055131510, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0006087
HARDING FIONA A ET AL: "The immunogenicity of humanized and fully human antibodies: Residual immunogenicity resides in the CDR regions", MABS, LANDES BIOSCIENCE, US, vol. 2, no. 3, 1 May 2010 (2010-05-01), pages 256 - 265, XP009137415, ISSN: 1942-0870, DOI: 10.4161/MABS.2.3.11641
HONGZHE ZHOU ET AL: "Generation of Monoclonal Antibodies against Highly Conserved Antigens", PLOS ONE, vol. 4, no. 6, 30 June 2009 (2009-06-30), pages e6087, XP055131510, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0006087
HARDING FIONA A ET AL: "The immunogenicity of humanized and fully human antibodies: Residual immunogenicity resides in the CDR regions", MABS, LANDES BIOSCIENCE, US, vol. 2, no. 3, 1 May 2010 (2010-05-01), pages 256 - 265, XP009137415, ISSN: 1942-0870, DOI: 10.4161/MABS.2.3.11641
Attorney, Agent or Firm:
WHITE, Nina (70 Gray's Inn RoadLondon Greater, London WC1X 8BT, GB)
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