Title:
ANTIBODIES DIRECTED AGAINST DISCOIDIN DOMAIN RECEPTOR FAMILY, MEMBER 1 (DDR1)
Document Type and Number:
WIPO Patent Application WO/2015/116569
Kind Code:
A3
Abstract:
The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to Discoidin Domain Receptor Family, Member 1 (DDR1). The invention provides a DDR1 -binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the DDR1 -binding agent to treat a DDRl -mediated disease.
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Inventors:
JUN HELEN TONI (US)
HORLICK ROBERT A (US)
KING DAVID J (US)
HORLICK ROBERT A (US)
KING DAVID J (US)
Application Number:
PCT/US2015/013027
Publication Date:
September 24, 2015
Filing Date:
January 27, 2015
Export Citation:
Assignee:
ANAPTYSBIO INC (US)
JUN HELEN TONI (US)
HORLICK ROBERT A (US)
KING DAVID J (US)
JUN HELEN TONI (US)
HORLICK ROBERT A (US)
KING DAVID J (US)
International Classes:
A61K39/395; C07K16/00; C12P21/08
Foreign References:
| US20070014720A1 | 2007-01-18 | |||
| US20110287011A1 | 2011-11-24 |
Other References:
CARAFOLI ET AL.: "Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling.", STRUCTURE, vol. 20, no. 4, 2012, pages 688 - 97, XP055090582
Attorney, Agent or Firm:
KOLOM, Melissa E. (Voit & Mayer Ltd.,180 North Stetson Avenue,Suite 490, Chicago Illinois, US)
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