Title:
ANTIBODIES RAISED AGAINST COLON CARCINOMAS
Document Type and Number:
WIPO Patent Application WO2005012361
Kind Code:
A3
Abstract:
The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
Inventors:
YOUNG DAVID S F
HAHN SUSAN E
FINDLAY HELEN P
HAHN SUSAN E
FINDLAY HELEN P
Application Number:
PCT/CA2004/000988
Publication Date:
May 19, 2005
Filing Date:
July 23, 2004
Export Citation:
Assignee:
ARIUS RES INC (CA)
International Classes:
A61P35/00; C07K16/30; G01N33/569; G01N33/574; (IPC1-7): C07K16/30; A61K39/395; A61P35/00; G01N33/574
Foreign References:
| EP0199141A2 | 1986-10-29 | |||
| EP0272113A2 | 1988-06-22 | |||
| EP0199586A2 | 1986-10-29 | |||
| US5171665A | 1992-12-15 | |||
| US20020041877A1 | 2002-04-11 |
Other References:
VAZQUEZ A M ET AL: "CHARACTERIZATION OF IOR C5 COLORECTAL TUMOR ASSOCIATED ANTIGEN", IMMUNOLOGIA, EDICIONES DOYMA, BARCELONA, ES, vol. 14, no. 3, 1995, pages 130 - 132, XP000677241, ISSN: 0213-9626
TORMO B R ET AL: "COLON CANCER ASSOCIATED ANTIGEN EXPRESSION ON NORMAL AND NEOPLASTICHUMAN TISSUES DETEDTED BY IORC2: A NOVEL MONOCLONAL ANTIBODY", BIOTECNOLOGIA APLICADA, LA HABANA, CU, vol. 8, no. 2, 1991, pages 206 - 215, XP000676466, ISSN: 1027-2852
TORMO B R ET AL: "COLON CANCER ASSOCIATED ANTIGEN EXPRESSION ON NORMAL AND NEOPLASTICHUMAN TISSUES DETEDTED BY IORC2: A NOVEL MONOCLONAL ANTIBODY", BIOTECNOLOGIA APLICADA, LA HABANA, CU, vol. 8, no. 2, 1991, pages 206 - 215, XP000676466, ISSN: 1027-2852
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