Title:
ANTIBODIES SPECIFIC FOR GLYCOPROTEIN VI AND METHODS OF PRODUCING THESE ANTIBODIES
Document Type and Number:
WIPO Patent Application WO2005111083
Kind Code:
A3
Abstract:
The present invention describes antibodies generated against platelet membrane glycoprotein VI (GPVI), methods of producing the anti-GPVI antibodies, and the use of these antibodies as research and immunotherapeutic agents, in particular, as antithrombotic therapeutic agents.
Inventors:
TANDON NARENDRA NATH (US)
MATSUMOTO YUTAKA (US)
TAKIZAWA HISAO (JP)
OKUYAMA KEIJI (JP)
MATSUMOTO YUTAKA (US)
TAKIZAWA HISAO (JP)
OKUYAMA KEIJI (JP)
Application Number:
PCT/US2005/014109
Publication Date:
February 09, 2006
Filing Date:
April 26, 2005
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
TANDON NARENDRA NATH (US)
MATSUMOTO YUTAKA (US)
TAKIZAWA HISAO (JP)
OKUYAMA KEIJI (JP)
TANDON NARENDRA NATH (US)
MATSUMOTO YUTAKA (US)
TAKIZAWA HISAO (JP)
OKUYAMA KEIJI (JP)
International Classes:
A61K39/395; A61P7/02; C07K16/28; (IPC1-7): C07K16/28; A61K39/395; A61P7/02
Domestic Patent References:
| WO2003054020A2 | 2003-07-03 |
Foreign References:
| US20040001826A1 | 2004-01-01 | |||
| US20020141992A1 | 2002-10-03 | |||
| EP1538165A1 | 2005-06-08 |
Other References:
DECLERCK PAUL J ET AL: "Generation of monoclonal antibodies against autologous proteins in gene-inactivated mice", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 270, no. 15, 14 April 1995 (1995-04-14), pages 8397 - 8400, XP002174630, ISSN: 0021-9258
KATO KAZUNOBU ET AL: "The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion.", BLOOD, vol. 102, no. 5, 1 September 2003 (2003-09-01), pages 1701 - 1707, XP002354224, ISSN: 0006-4971
QIAN MING D ET AL: "Anti GPVI human antibodies neutralizing collagen-induced platelet aggregation isolated from a combinatorial phage display library.", HUMAN ANTIBODIES, vol. 11, no. 3, 2002, pages 97 - 105, XP009056880, ISSN: 1093-2607
DAVIES J ET AL: "Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding", IMMUNOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 2, no. 3, September 1996 (1996-09-01), pages 169 - 179, XP004070292, ISSN: 1380-2933
KATO KAZUNOBU ET AL: "The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion.", BLOOD, vol. 102, no. 5, 1 September 2003 (2003-09-01), pages 1701 - 1707, XP002354224, ISSN: 0006-4971
QIAN MING D ET AL: "Anti GPVI human antibodies neutralizing collagen-induced platelet aggregation isolated from a combinatorial phage display library.", HUMAN ANTIBODIES, vol. 11, no. 3, 2002, pages 97 - 105, XP009056880, ISSN: 1093-2607
DAVIES J ET AL: "Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding", IMMUNOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 2, no. 3, September 1996 (1996-09-01), pages 169 - 179, XP004070292, ISSN: 1380-2933
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