Title:
ANTIBODIES SPECIFIC TO TROPHOBLAST ANTIGEN 2 (TROP2)
Document Type and Number:
WIPO Patent Application WO/2020/016662
Kind Code:
A3
Abstract:
Antibodies specific to trophoblast antigen 2 (TROP2) and uses thereof for therapeutic and diagnostic purposes. Also provided are chimeric antigen receptors (CARs) comprising an extracellular antigen-binding fragment that binds TROP2 and immune cells expressing such.
Inventors:
HOU BING (CN)
MENG XUN (CN)
WANG NA (CN)
MENG XUN (CN)
WANG NA (CN)
Application Number:
PCT/IB2019/000875
Publication Date:
April 02, 2020
Filing Date:
June 26, 2019
Export Citation:
Assignee:
ABMART INC (CN)
International Classes:
C12N15/09; A61K39/395; A61P35/00; C07K16/28; C12N1/15; C12N5/10
Domestic Patent References:
| WO2013068946A2 | 2013-05-16 | |||
| WO2017172981A2 | 2017-10-05 | |||
| WO2015047510A1 | 2015-04-02 | |||
| WO2017189279A1 | 2017-11-02 |
Foreign References:
| CN105849126A | 2016-08-10 | |||
| CN107446050A | 2017-12-08 | |||
| CN105925536A | 2016-09-07 |
Other References:
XU, Y.R. ET AL.: "Construction of Trop-2-targeted chimeric antigen receptor-modified T cells and their effects on the proliferation of ovarian cancer cells in vitro", ACTA UNIVERSITATIS MEDICINALIS NANJING ( NATURAL SCIENCE, vol. 37, no. 6, 30 June 2017 (2017-06-30), pages 653 - 658, XP055777760
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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